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    DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory [ Homo sapiens (human) ]

    Gene ID: 8818, updated on 8-Jul-2021

    Summary

    Official Symbol
    DPM2provided by HGNC
    Official Full Name
    dolichyl-phosphate mannosyltransferase subunit 2, regulatoryprovided by HGNC
    Primary source
    HGNC:HGNC:3006
    See related
    Ensembl:ENSG00000136908 MIM:603564
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDG1U
    Summary
    Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in stomach (RPKM 13.1), thyroid (RPKM 12.2) and 25 other tissues See more
    Orthologs
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    Genomic context

    See DPM2 in Genome Data Viewer
    Location:
    9q34.11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (127935099..127937854, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130697378..130700133, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase like 1 Neighboring gene family with sequence similarity 102 member A Neighboring gene Sharpr-MPRA regulatory region 6856 Neighboring gene conserved acetylation island sequence 15 enhancer

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ80013, MGC21559, MGC111193

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in GPI anchor biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dolichol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein O-linked mannosylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein stability IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    dolichol phosphate-mannose biosynthesis regulatory protein
    Names
    DPM synthase complex subunit
    DPM synthase subunit 2
    dolichol-phosphate mannose synthase subunit 2
    dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
    NP_001365365.1
    NP_001365366.1
    NP_003854.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032927.1 RefSeqGene

      Range
      5001..8390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001378436.1NP_001365365.1  dolichol phosphate-mannose biosynthesis regulatory protein isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL157935
      Conserved Domains (1) summary
      pfam07297
      Location:531
      DPM2; Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)
    2. NM_001378437.1NP_001365366.1  dolichol phosphate-mannose biosynthesis regulatory protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL157935
      Conserved Domains (1) summary
      pfam07297
      Location:148
      DPM2; Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)
    3. NM_003863.4NP_003854.1  dolichol phosphate-mannose biosynthesis regulatory protein isoform 1

      See identical proteins and their annotated locations for NP_003854.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL157935
      Consensus CDS
      CCDS6886.1
      UniProtKB/Swiss-Prot
      O94777
      Related
      ENSP00000322181.8, ENST00000314392.13
      Conserved Domains (1) summary
      pfam07297
      Location:578
      DPM2; Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)

    RNA

    1. NR_165631.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL157935
    2. NR_165632.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL157935

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      127935099..127937854 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_152690.1: Suppressed sequence

      Description
      NM_152690.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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