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    IL1RL2 interleukin 1 receptor like 2 [ Homo sapiens (human) ]

    Gene ID: 8808, updated on 11-Apr-2024

    Summary

    Official Symbol
    IL1RL2provided by HGNC
    Official Full Name
    interleukin 1 receptor like 2provided by HGNC
    Primary source
    HGNC:HGNC:5999
    See related
    Ensembl:ENSG00000115598 MIM:604512; AllianceGenome:HGNC:5999
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IL-36R; IL1RRP2; IL-1Rrp2; IL1R-rp2
    Summary
    The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in skin (RPKM 3.4), esophagus (RPKM 1.6) and 11 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IL1RL2 in Genome Data Viewer
    Location:
    2q12.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (102186973..102243086)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (102645259..102701349)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102803433..102856462)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:102657879-102659078 Neighboring gene uncharacterized LOC107985926 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:102674234-102674816 Neighboring gene interleukin 1 receptor type 1 Neighboring gene Sharpr-MPRA regulatory regions 1871 and 11985 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:102775959-102776153 Neighboring gene IL1R1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102803139-102803668 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:102813537-102814736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102851302-102851802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102851803-102852303 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:102854175-102855374 Neighboring gene Sharpr-MPRA regulatory region 14071 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102867123-102867716 Neighboring gene CFAP144 pseudogene 2 Neighboring gene interleukin 1 receptor like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
    EBI GWAS Catalog
    Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.
    EBI GWAS Catalog
    Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NAD+ nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
     
    enables interleukin-1 receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables interleukin-1, type I, activating receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in interleukin-1-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    interleukin-1 receptor-like 2
    Names
    IL-1 receptor-related protein 2
    IL-36 receptor
    interleukin-1 receptor-related protein 2
    NP_001338375.1
    NP_001338376.1
    NP_001338377.1
    NP_001338378.1
    NP_001338379.1
    NP_003845.2
    XP_006712885.1
    XP_011510393.2
    XP_011510394.2
    XP_011510395.2
    XP_011510396.1
    XP_011510398.2
    XP_016860663.2
    XP_047302120.1
    XP_047302121.1
    XP_047302122.1
    XP_054200322.1
    XP_054200323.1
    XP_054200324.1
    XP_054200325.1
    XP_054200326.1
    XP_054200327.1
    XP_054200328.1
    XP_054200329.1
    XP_054200330.1
    XP_054200331.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001351446.2NP_001338375.1  interleukin-1 receptor-like 2 isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variant 1, encodes the longest isoform (a).
      Source sequence(s)
      AC007248, AK315334, BC107064, CA448166
      Consensus CDS
      CCDS2056.1
      UniProtKB/Swiss-Prot
      A4FU63, Q13525, Q45H74, Q53TU8, Q587I8, Q9HB29
      UniProtKB/TrEMBL
      B2RCY7
      Conserved Domains (3) summary
      pfam01582
      Location:386536
      TIR; TIR domain
      cd05757
      Location:130218
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cl11960
      Location:26112
      Ig; Immunoglobulin domain
    2. NM_001351447.1NP_001338376.1  interleukin-1 receptor-like 2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes isoform b.
      Source sequence(s)
      AC007271, AF284434, BC107064, CA448166
      Consensus CDS
      CCDS86867.1
      Related
      ENSP00000413348.2, ENST00000441515.3
      Conserved Domains (2) summary
      pfam01582
      Location:268418
      TIR; TIR domain
      cl11960
      Location:46100
      Ig; Immunoglobulin domain
    3. NM_001351448.1NP_001338377.1  interleukin-1 receptor-like 2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes isoform c.
      Source sequence(s)
      AC007248, AC007271
      Conserved Domains (2) summary
      pfam01582
      Location:244394
      TIR; TIR domain
      cl11960
      Location:4699
      Ig; Immunoglobulin domain
    4. NM_001351449.2NP_001338378.1  interleukin-1 receptor-like 2 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variant 6, encodes isoform d.
      Source sequence(s)
      AC007248, AC007271
      Conserved Domains (2) summary
      pfam01582
      Location:235385
      TIR; TIR domain
      cl11960
      Location:1167
      Ig; Immunoglobulin domain
    5. NM_001351450.2NP_001338379.1  interleukin-1 receptor-like 2 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variant 5, encodes isoform d.
      Source sequence(s)
      AC007248, AC007271
      Conserved Domains (2) summary
      pfam01582
      Location:235385
      TIR; TIR domain
      cl11960
      Location:1167
      Ig; Immunoglobulin domain
    6. NM_003854.4NP_003845.2  interleukin-1 receptor-like 2 isoform a precursor

      See identical proteins and their annotated locations for NP_003845.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variant 2, encodes the longest isoform (a).
      Source sequence(s)
      AF284434, BC107064, CA448166
      Consensus CDS
      CCDS2056.1
      UniProtKB/Swiss-Prot
      A4FU63, Q13525, Q45H74, Q53TU8, Q587I8, Q9HB29
      UniProtKB/TrEMBL
      B2RCY7
      Related
      ENSP00000264257.2, ENST00000264257.7
      Conserved Domains (3) summary
      pfam01582
      Location:386536
      TIR; TIR domain
      cd05757
      Location:130218
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cl11960
      Location:26112
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      102186973..102243086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005174.3XP_016860663.2  interleukin-1 receptor-like 2 isoform X3

    2. XM_011512096.2XP_011510398.2  interleukin-1 receptor-like 2 isoform X7

    3. XM_011512091.2XP_011510393.2  interleukin-1 receptor-like 2 isoform X1

    4. XM_011512093.2XP_011510395.2  interleukin-1 receptor-like 2 isoform X4

    5. XM_047446165.1XP_047302121.1  interleukin-1 receptor-like 2 isoform X6

    6. XM_011512092.2XP_011510394.2  interleukin-1 receptor-like 2 isoform X2

    7. XM_011512094.2XP_011510396.1  interleukin-1 receptor-like 2 isoform X5

      See identical proteins and their annotated locations for XP_011510396.1

      UniProtKB/TrEMBL
      B2RCY7
      Conserved Domains (4) summary
      cd05757
      Location:130218
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00410
      Location:40112
      IG_like; Immunoglobulin like
      pfam01582
      Location:386536
      TIR; TIR domain
      cl11960
      Location:26112
      Ig; Immunoglobulin domain
    8. XM_047446164.1XP_047302120.1  interleukin-1 receptor-like 2 isoform X1

    9. XM_006712822.4XP_006712885.1  interleukin-1 receptor-like 2 isoform X8

      Conserved Domains (2) summary
      pfam01582
      Location:235385
      TIR; TIR domain
      cl11960
      Location:1167
      Ig; Immunoglobulin domain
    10. XM_047446166.1XP_047302122.1  interleukin-1 receptor-like 2 isoform X9

    RNA

    1. XR_923053.3 RNA Sequence

    2. XR_007083521.1 RNA Sequence

    3. XR_007083520.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      102645259..102701349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344349.1XP_054200324.1  interleukin-1 receptor-like 2 isoform X3

    2. XM_054344354.1XP_054200329.1  interleukin-1 receptor-like 2 isoform X7

    3. XM_054344347.1XP_054200322.1  interleukin-1 receptor-like 2 isoform X1

    4. XM_054344350.1XP_054200325.1  interleukin-1 receptor-like 2 isoform X4

    5. XM_054344353.1XP_054200328.1  interleukin-1 receptor-like 2 isoform X6

    6. XM_054344348.1XP_054200323.1  interleukin-1 receptor-like 2 isoform X2

    7. XM_054344351.1XP_054200326.1  interleukin-1 receptor-like 2 isoform X5

    8. XM_054344352.1XP_054200327.1  interleukin-1 receptor-like 2 isoform X1

    9. XM_054344355.1XP_054200330.1  interleukin-1 receptor-like 2 isoform X8

    10. XM_054344356.1XP_054200331.1  interleukin-1 receptor-like 2 isoform X9

    RNA

    1. XR_008486578.1 RNA Sequence

    2. XR_008486577.1 RNA Sequence

    3. XR_008486576.1 RNA Sequence