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    FADD Fas associated via death domain [ Homo sapiens (human) ]

    Gene ID: 8772, updated on 8-Jul-2021

    Summary

    Official Symbol
    FADDprovided by HGNC
    Official Full Name
    Fas associated via death domainprovided by HGNC
    Primary source
    HGNC:HGNC:3573
    See related
    Ensembl:ENSG00000168040 MIM:602457
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GIG3; MORT1
    Summary
    The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 9.3), colon (RPKM 8.7) and 25 other tissues See more
    Orthologs
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    Genomic context

    See FADD in Genome Data Viewer
    Location:
    11q13.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (70203296..70207390)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (70049402..70053496)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene anoctamin 1 Neighboring gene uncharacterized LOC105369372 Neighboring gene uncharacterized LOC101928473 Neighboring gene PTPRF interacting protein alpha 1 Neighboring gene H2A.Z histone pseudogene 4 Neighboring gene microRNA 548k

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-induced neuron apoptosis requires the upregulation of the death receptor Fas and its associated death proteins, FADD and CASP8 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC8528

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables caspase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables caspase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables caspase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables death effector domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables death receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor serine/threonine kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tumor necrosis factor receptor superfamily binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T cell differentiation in thymus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in T cell homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in TRAIL-activated apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in TRAIL-activated apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in activation of cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in behavioral response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in death-inducing signaling complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in extrinsic apoptotic signaling pathway via death domain receptors IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in kidney development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lymph node development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in motor neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in necroptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of activation-induced cell death of T cells ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of necroptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of T cell mediated cytotoxicity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of activated T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of adaptive immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interferon-gamma production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-8 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of macrophage differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of type I interferon-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to morphine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spleen development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in thymus development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of CD95 death-inducing signaling complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of CD95 death-inducing signaling complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell body IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of death-inducing signaling complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of death-inducing signaling complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ripoptosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    FAS-associated death domain protein
    Names
    Fas (TNFRSF6)-associated via death domain
    Fas-associating death domain-containing protein
    Fas-associating protein with death domain
    growth-inhibiting gene 3 protein
    mediator of receptor-induced toxicity

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027966.1 RefSeqGene

      Range
      5001..9240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_228

    mRNA and Protein(s)

    1. NM_003824.4NP_003815.1  FAS-associated death domain protein

      See identical proteins and their annotated locations for NP_003815.1

      Status: REVIEWED

      Source sequence(s)
      AI886015, AL575732, AP000879, BC000334
      Consensus CDS
      CCDS8196.1
      UniProtKB/Swiss-Prot
      Q13158
      Related
      ENSP00000301838.5, ENST00000301838.5
      Conserved Domains (2) summary
      cd08306
      Location:97181
      Death_FADD; Fas-associated Death Domain protein-protein interaction domain
      cd08336
      Location:2482
      DED_FADD; Death Effector Domain found in Fas-Associated via Death Domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      70203296..70207390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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