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    CBR1 carbonyl reductase 1 [ Homo sapiens (human) ]

    Gene ID: 873, updated on 19-Jun-2024

    Summary

    Official Symbol
    CBR1provided by HGNC
    Official Full Name
    carbonyl reductase 1provided by HGNC
    Primary source
    HGNC:HGNC:1548
    See related
    Ensembl:ENSG00000159228 MIM:114830; AllianceGenome:HGNC:1548
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CBR; hCBR1; PG-9-KR; SDR21C1
    Summary
    The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
    Expression
    Broad expression in duodenum (RPKM 163.2), small intestine (RPKM 98.7) and 19 other tissues See more
    Orthologs
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    Genomic context

    See CBR1 in Genome Data Viewer
    Location:
    21q22.12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (36070024..36073164)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (34453083..34456223)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (37442322..37445462)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene SETD4 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18423 Neighboring gene RNA, U6 small nuclear 992, pseudogene Neighboring gene CBR1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18424 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:37471927-37472788 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:37477035-37477536 Neighboring gene uncharacterized LOC105369306 Neighboring gene MPRA-validated peak4410 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18425 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18426 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37485624-37486136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18427 Neighboring gene MEMO1 pseudogene 1 Neighboring gene CBR3 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    General protein information

    Preferred Names
    carbonyl reductase [NADPH] 1
    Names
    15-hydroxyprostaglandin dehydrogenase
    20-beta-hydroxysteroid dehydrogenase
    NADPH-dependent carbonyl reductase 1
    alcohol dehydrogenase [NAD(P)+] CBR1
    carbonyl reductase (NADPH) 1
    epididymis secretory sperm binding protein
    prostaglandin 9-ketoreductase
    prostaglandin-E(2) 9-reductase
    short chain dehydrogenase/reductase family 21C member 1
    NP_001273718.1
    NP_001748.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286789.2NP_001273718.1  carbonyl reductase [NADPH] 1 isoform 2

      See identical proteins and their annotated locations for NP_001273718.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon that causes a frame-shift compared to variant 1. The resulting shorter isoform (2) has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK294142, AK311219
      Consensus CDS
      CCDS68202.1
      UniProtKB/Swiss-Prot
      P16152
      Related
      ENSP00000434613.1, ENST00000530908.5
      Conserved Domains (1) summary
      cl21454
      Location:6131
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. NM_001757.4NP_001748.1  carbonyl reductase [NADPH] 1 isoform 1

      See identical proteins and their annotated locations for NP_001748.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AB124848
      Consensus CDS
      CCDS13641.1
      UniProtKB/Swiss-Prot
      B2RBZ7, B4DFK7, P16152, Q3LHW8
      UniProtKB/TrEMBL
      A0A384NL53
      Related
      ENSP00000290349.6, ENST00000290349.11
      Conserved Domains (1) summary
      cd05324
      Location:6277
      carb_red_PTCR-like_SDR_c; Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      36070024..36073164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      34453083..34456223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)