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    URI1 URI1 prefoldin like chaperone [ Homo sapiens (human) ]

    Gene ID: 8725, updated on 17-Jun-2024

    Summary

    Official Symbol
    URI1provided by HGNC
    Official Full Name
    URI1 prefoldin like chaperoneprovided by HGNC
    Primary source
    HGNC:HGNC:13236
    See related
    Ensembl:ENSG00000105176 MIM:603494; AllianceGenome:HGNC:13236
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RMP; URI; NNX3; C19orf2; PPP1R19
    Summary
    This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]
    Expression
    Ubiquitous expression in thyroid (RPKM 23.9), testis (RPKM 18.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See URI1 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (29923657..30016612)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (32444098..32537026)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (30414564..30507519)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14421 Neighboring gene cyclin E1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:30348658-30349496 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:30349497-30350334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10470 Neighboring gene Sharpr-MPRA regulatory region 11671 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:30373138-30373673 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr19:30418723-30419224 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr19:30419225-30419724 Neighboring gene peptidylprolyl isomerase A pseudogene 58 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14424 Neighboring gene ribosomal protein L9 pseudogene 32 Neighboring gene VISTA enhancer hs381 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14425 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:30521325-30521824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14426 Neighboring gene TATA-box binding protein associated factor 9 pseudogene 3 Neighboring gene VISTA enhancer hs382 Neighboring gene uncharacterized LOC107985271 Neighboring gene VISTA enhancer hs721 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14427

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10575

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RPAP3/R2TP/prefoldin-like complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein folding chaperone complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    unconventional prefoldin RPB5 interactor 1
    Names
    RNA polymerase II subunit 5-mediating protein
    RPB5-mediating protein
    protein phosphatase 1, regulatory subunit 19

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047095.1 RefSeqGene

      Range
      23596..97969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001252641.2NP_001239570.1  unconventional prefoldin RPB5 interactor 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' UTRs and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) is shorter and has distinct N- and C-termini, compared to isoform a.
      Source sequence(s)
      AA678820, AW003989, AW954529, BC026184, BG742069
      Consensus CDS
      CCDS58658.1
      UniProtKB/TrEMBL
      Q6NX55
      Related
      ENSP00000353817.4, ENST00000360605.8
      Conserved Domains (1) summary
      cl09111
      Location:27129
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    2. NM_003796.3NP_003787.2  unconventional prefoldin RPB5 interactor 1 isoform a

      See identical proteins and their annotated locations for NP_003787.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AA678820, AK292170, AW003989, AW954529, BG742069, DB461036
      Consensus CDS
      CCDS12420.1
      UniProtKB/Swiss-Prot
      A8K805, H7BY42, O94763, Q8TC23, Q9UNU3
      UniProtKB/TrEMBL
      Q6NX55
      Related
      ENSP00000376097.2, ENST00000392271.6
      Conserved Domains (1) summary
      cl09111
      Location:38147
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    RNA

    1. NR_045557.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA678820, AW003989, AW954529, BC067259, BG742069, DB461036

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      29923657..30016612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005259362.3XP_005259419.1  unconventional prefoldin RPB5 interactor 1 isoform X1

      UniProtKB/TrEMBL
      Q6NX55
      Conserved Domains (1) summary
      cl09111
      Location:27129
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    2. XM_047439595.1XP_047295551.1  unconventional prefoldin RPB5 interactor 1 isoform X4

      UniProtKB/TrEMBL
      Q6NX55
    3. XM_011527435.3XP_011525737.1  unconventional prefoldin RPB5 interactor 1 isoform X3

      UniProtKB/TrEMBL
      Q6NX55
      Conserved Domains (1) summary
      cl09111
      Location:899
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    4. XM_005259363.5XP_005259420.1  unconventional prefoldin RPB5 interactor 1 isoform X2

      UniProtKB/TrEMBL
      Q6NX55
      Conserved Domains (1) summary
      cl09111
      Location:38147
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    5. XM_047439596.1XP_047295552.1  unconventional prefoldin RPB5 interactor 1 isoform X5

      UniProtKB/TrEMBL
      Q6NX55

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      32444098..32537026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322482.1XP_054178457.1  unconventional prefoldin RPB5 interactor 1 isoform X1

      UniProtKB/TrEMBL
      Q6NX55
    2. XM_054322485.1XP_054178460.1  unconventional prefoldin RPB5 interactor 1 isoform X4

      UniProtKB/TrEMBL
      Q6NX55
    3. XM_054322484.1XP_054178459.1  unconventional prefoldin RPB5 interactor 1 isoform X3

      UniProtKB/TrEMBL
      Q6NX55
    4. XM_054322483.1XP_054178458.1  unconventional prefoldin RPB5 interactor 1 isoform X2

      UniProtKB/TrEMBL
      Q6NX55
    5. XM_054322486.1XP_054178461.1  unconventional prefoldin RPB5 interactor 1 isoform X5

      UniProtKB/TrEMBL
      Q6NX55

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_134447.1: Suppressed sequence

      Description
      NM_134447.1: This RefSeq was permanently suppressed because it has an inhibitory upstream ORF and there is no support for the protein.