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    MARCO macrophage receptor with collagenous structure [ Homo sapiens (human) ]

    Gene ID: 8685, updated on 5-May-2024

    Summary

    Official Symbol
    MARCOprovided by HGNC
    Official Full Name
    macrophage receptor with collagenous structureprovided by HGNC
    Primary source
    HGNC:HGNC:6895
    See related
    Ensembl:ENSG00000019169 MIM:604870; AllianceGenome:HGNC:6895
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SR-A6; SCARA2
    Summary
    The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in lung (RPKM 74.5), appendix (RPKM 41.8) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MARCO in Genome Data Viewer
    Location:
    2q14.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (118942194..118994660)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (119375479..119427929)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (119699770..119752236)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119590580-119591348 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:119599819-119600399 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr2:119602243-119602892 and GRCh37_chr2:119602893-119603542 Neighboring gene long intergenic non-protein coding RNA 1956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:119607811-119608363 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119610971-119611506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:119615003-119615764 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:119615765-119616526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119616527-119617286 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11898 Neighboring gene engrailed homeobox 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:119671170-119672369 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:119711468-119712667 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119746563-119747064 Neighboring gene uncharacterized LOC124906072 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:119749973-119751172 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:119807422-119808621 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:119843263-119843429 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:119868745-119869944 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119870527-119871192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119891922-119892422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119892423-119892923 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:119914695-119915505 Neighboring gene RNA, 7SL, cytoplasmic 468, pseudogene Neighboring gene complement C1q like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr potentiates the stimulation of macrophage receptor with collagenous structure by glucocorticoids via the glucocorticoid receptor pathway PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables amyloid-beta binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cargo receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables pattern recognition receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables transmembrane signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in amyloid-beta clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in apoptotic cell clearance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phagocytosis, engulfment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    macrophage receptor MARCO
    Names
    scavenger receptor class A, member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006770.4NP_006761.1  macrophage receptor MARCO

      See identical proteins and their annotated locations for NP_006761.1

      Status: REVIEWED

      Source sequence(s)
      AC013457
      Consensus CDS
      CCDS2124.1
      UniProtKB/Swiss-Prot
      B4DW79, Q9UEW3, Q9Y5S3
      UniProtKB/TrEMBL
      B4DLJ6, Q4ZG40
      Related
      ENSP00000318916.4, ENST00000327097.5
      Conserved Domains (2) summary
      pfam01391
      Location:286344
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:424519
      SR; Scavenger receptor Cys-rich

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      118942194..118994660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512082.3XP_011510384.1  macrophage receptor MARCO isoform X1

      See identical proteins and their annotated locations for XP_011510384.1

      UniProtKB/Swiss-Prot
      B4DW79, Q9UEW3, Q9Y5S3
      UniProtKB/TrEMBL
      B4DLJ6, Q4ZG40
      Conserved Domains (2) summary
      pfam01391
      Location:286344
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:424519
      SR; Scavenger receptor Cys-rich
    2. XM_011512083.4XP_011510385.1  macrophage receptor MARCO isoform X2

      Conserved Domains (3) summary
      pfam01391
      Location:165223
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:303398
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:308398
      SRCR; Scavenger receptor cysteine-rich domain
    3. XM_017005171.3XP_016860660.1  macrophage receptor MARCO isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      119375479..119427929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344329.1XP_054200304.1  macrophage receptor MARCO isoform X1

      UniProtKB/Swiss-Prot
      B4DW79, Q9UEW3, Q9Y5S3
      UniProtKB/TrEMBL
      Q4ZG40
    2. XM_054344330.1XP_054200305.1  macrophage receptor MARCO isoform X2

    3. XM_054344331.1XP_054200306.1  macrophage receptor MARCO isoform X3