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    STX11 syntaxin 11 [ Homo sapiens (human) ]

    Gene ID: 8676, updated on 11-Jun-2021

    Summary

    Official Symbol
    STX11provided by HGNC
    Official Full Name
    syntaxin 11provided by HGNC
    Primary source
    HGNC:HGNC:11429
    See related
    Ensembl:ENSG00000135604 MIM:605014
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FHL4; HLH4; HPLH4
    Summary
    This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in bone marrow (RPKM 13.4), fat (RPKM 5.2) and 8 other tissues See more
    Orthologs
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    Genomic context

    See STX11 in Genome Data Viewer
    Location:
    6q24.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (144140044..144191939)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (144471654..144513076)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378036 Neighboring gene mitochondrial ribosomal protein L42 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 5218 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in membrane fusion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007613.1 RefSeqGene

      Range
      5001..46423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_113

    mRNA and Protein(s)

    1. NM_003764.4NP_003755.2  syntaxin-11

      See identical proteins and their annotated locations for NP_003755.2

      Status: REVIEWED

      Source sequence(s)
      AI791689, AL135917, BC033519, BF941242, BM150302, BQ030324, CR739089
      Consensus CDS
      CCDS5205.1
      UniProtKB/Swiss-Prot
      O75558
      Related
      ENSP00000356540.4, ENST00000367568.5
      Conserved Domains (2) summary
      pfam00804
      Location:41238
      Syntaxin; Syntaxin
      cl22856
      Location:207273
      SNARE; SNARE motif

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      144140044..144191939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536213.2XP_011534515.1  syntaxin-11 isoform X1

      Conserved Domains (3) summary
      cd00179
      Location:67219
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
      cd15878
      Location:229291
      SNARE_syntaxin11; SNARE motif of syntaxin 11
      pfam00804
      Location:67264
      Syntaxin; Syntaxin
    2. XM_011536218.2XP_011534520.1  syntaxin-11 isoform X2

      See identical proteins and their annotated locations for XP_011534520.1

      UniProtKB/Swiss-Prot
      O75558
      Conserved Domains (2) summary
      pfam00804
      Location:41238
      Syntaxin; Syntaxin
      cl22856
      Location:207273
      SNARE; SNARE motif
    3. XM_011536214.2XP_011534516.1  syntaxin-11 isoform X2

      See identical proteins and their annotated locations for XP_011534516.1

      UniProtKB/Swiss-Prot
      O75558
      Conserved Domains (2) summary
      pfam00804
      Location:41238
      Syntaxin; Syntaxin
      cl22856
      Location:207273
      SNARE; SNARE motif
    4. XM_017011400.1XP_016866889.1  syntaxin-11 isoform X2

      UniProtKB/Swiss-Prot
      O75558
      Conserved Domains (2) summary
      pfam00804
      Location:41238
      Syntaxin; Syntaxin
      cl22856
      Location:207273
      SNARE; SNARE motif
    5. XM_011536217.2XP_011534519.1  syntaxin-11 isoform X2

      See identical proteins and their annotated locations for XP_011534519.1

      UniProtKB/Swiss-Prot
      O75558
      Conserved Domains (2) summary
      pfam00804
      Location:41238
      Syntaxin; Syntaxin
      cl22856
      Location:207273
      SNARE; SNARE motif

    RNA

    1. XR_001743702.1 RNA Sequence

    2. XR_942613.2 RNA Sequence

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