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    PLPP1 phospholipid phosphatase 1 [ Homo sapiens (human) ]

    Gene ID: 8611, updated on 21-Dec-2019

    Summary

    Official Symbol
    PLPP1provided by HGNC
    Official Full Name
    phospholipid phosphatase 1provided by HGNC
    Primary source
    HGNC:HGNC:9228
    See related
    Ensembl:ENSG00000067113 MIM:607124
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LPP1; PAP2; LLP1a; PAP-2a; PPAP2A
    Summary
    The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
    Expression
    Broad expression in prostate (RPKM 96.2), gall bladder (RPKM 74.3) and 22 other tissues See more
    Orthologs

    Genomic context

    See PLPP1 in Genome Data Viewer
    Location:
    5q11.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (55424842..55535078, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (54720670..54830906, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Mtr4 exosome RNA helicase Neighboring gene protein serine kinase H1 pseudogene Neighboring gene uncharacterized LOC107986415 Neighboring gene microRNA 5687 Neighboring gene ring finger protein 138 pseudogene 1 Neighboring gene adenylate kinase 4 pseudogene 2 Neighboring gene uncharacterized LOC105378975

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ42210

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    lipid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lipid phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidate phosphatase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    sphingosine-1-phosphate phosphatase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    androgen receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    germ cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    intracellular steroid hormone receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    lipid metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of cell proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phospholipid dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipid dephosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase C-activating G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of lipid metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    sphingolipid biosynthetic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    extracellular exosome HDA PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    phospholipid phosphatase 1
    Names
    lipid phosphate phosphohydrolase 1a
    phosphatidate phosphohydrolase type 2a
    phosphatidic acid phosphatase 2a
    phosphatidic acid phosphatase type 2A
    phosphatidic acid phosphohydrolase type 2a
    type-2 phosphatidic acid phosphatase alpha
    NP_003702.2
    NP_795714.1
    XP_006714787.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003711.4NP_003702.2  phospholipid phosphatase 1 isoform 1

      See identical proteins and their annotated locations for NP_003702.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also named PAP2-a1) lacks an alternate exon and contains an in-frame alternate exon in the 5' coding region, compared to variant 2. The resulting isoform (1) contains a distinct internal segment and is shorter, compared to isoform 2.
      Source sequence(s)
      AF014402, BC008787, BC039847, BC143281
      Consensus CDS
      CCDS34159.1
      UniProtKB/Swiss-Prot
      O14494
      UniProtKB/TrEMBL
      A0A024QZS3
      Related
      ENSP00000302229.8, ENST00000307259.9
      Conserved Domains (1) summary
      cd03384
      Location:98243
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
    2. NM_176895.2NP_795714.1  phospholipid phosphatase 1 isoform 2

      See identical proteins and their annotated locations for NP_795714.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also named PAP2-a2) encodes the longer isoform (2).
      Source sequence(s)
      AF014403, BC008787, BC039847, BC168254, BQ019387, CN338068, HY063640
      Consensus CDS
      CCDS34160.1
      UniProtKB/Swiss-Prot
      O14494
      UniProtKB/TrEMBL
      A0A024QZU7
      Related
      ENSP00000264775.5, ENST00000264775.9
      Conserved Domains (1) summary
      cd03384
      Location:99244
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    RNA

    1. NR_103485.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 5' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF014402, BC008787, BC039847, BC168254, BQ019387, CN338068, HY063640

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      55424842..55535078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006714724.3XP_006714787.1  phospholipid phosphatase 1 isoform X1

      Conserved Domains (1) summary
      cd03384
      Location:35180
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
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