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    KLF7 KLF transcription factor 7 [ Homo sapiens (human) ]

    Gene ID: 8609, updated on 17-Jun-2024

    Summary

    Official Symbol
    KLF7provided by HGNC
    Official Full Name
    KLF transcription factor 7provided by HGNC
    Primary source
    HGNC:HGNC:6350
    See related
    Ensembl:ENSG00000118263 MIM:604865; AllianceGenome:HGNC:6350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UKLF
    Summary
    The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
    Expression
    Ubiquitous expression in bone marrow (RPKM 4.7), endometrium (RPKM 4.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KLF7 in Genome Data Viewer
    Location:
    2q33.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (207074137..207173851, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (207556313..207657581, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (207938861..208031970, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene FAST kinase domains 2 Neighboring gene microRNA 3130-1 Neighboring gene microRNA 3130-2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:207671457-207672284 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:207676275-207676890 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:207676891-207677508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12270 Neighboring gene carboxypeptidase O Neighboring gene Sharpr-MPRA regulatory region 8398 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:207901421-207902246 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:207902247-207903074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17029 Neighboring gene Sharpr-MPRA regulatory region 11101 Neighboring gene NANOG hESC enhancer GRCh37_chr2:208007006-208007507 Neighboring gene microRNA 2355 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:208013849-208014350 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12271 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:208028265-208028973 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:208028974-208029682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17030 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr2:208030391-208031099 and GRCh37_chr2:208031100-208031807 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:208031808-208032516 Neighboring gene MYOSLID antisense RNA 1 Neighboring gene microRNA 7845 Neighboring gene NANOG hESC enhancer GRCh37_chr2:208064814-208065392 Neighboring gene MPRA-validated peak4025 silencer Neighboring gene uncharacterized LOC124907971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17032 Neighboring gene myocardin-induced smooth muscle lncRNA, inducer of differentiation

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Krueppel-like factor 7
    Names
    Kruppel like factor 7
    Kruppel-like factor 7 (ubiquitous)
    ubiquitous Kruppel-like factor
    ubiquitous Kruppel-like transcription factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052989.2 RefSeqGene

      Range
      12903..104714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270942.1NP_001257871.1  Krueppel-like factor 7 isoform 2

      See identical proteins and their annotated locations for NP_001257871.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the coding region that results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC008062, BC012919, DA800775
      Consensus CDS
      CCDS59439.1
      UniProtKB/Swiss-Prot
      O75840
      Related
      ENSP00000398572.1, ENST00000423015.5
    2. NM_001270943.2NP_001257872.1  Krueppel-like factor 7 isoform 3

      See identical proteins and their annotated locations for NP_001257872.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The resulting protein (isoform 3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC007879, AC008062
      Consensus CDS
      CCDS59440.1
      UniProtKB/TrEMBL
      Q4ZG79
      Related
      ENSP00000387510.1, ENST00000421199.5
      Conserved Domains (3) summary
      COG5048
      Location:179251
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:191210
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:246268
      zf-C2H2; Zinc finger, C2H2 type
    3. NM_001270944.2NP_001257873.1  Krueppel-like factor 7 isoform 4

      See identical proteins and their annotated locations for NP_001257873.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC007879, AC008062
      Consensus CDS
      CCDS59438.1
      UniProtKB/TrEMBL
      Q4ZG79
      Related
      ENSP00000413590.2, ENST00000435602.2
      Conserved Domains (3) summary
      COG5048
      Location:184256
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:196215
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:251273
      zf-C2H2; Zinc finger, C2H2 type
    4. NM_003709.4NP_003700.1  Krueppel-like factor 7 isoform 1

      See identical proteins and their annotated locations for NP_003700.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC007879, AC008062
      Consensus CDS
      CCDS2373.1
      UniProtKB/Swiss-Prot
      B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
      UniProtKB/TrEMBL
      B3KNE6
      Related
      ENSP00000309570.6, ENST00000309446.11
      Conserved Domains (5) summary
      COG5048
      Location:212284
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:224243
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:279301
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:265290
      zf-H2C2_2; Zinc-finger double domain
      cd21585
      Location:2220
      KLF7_N; N-terminal domain of Kruppel-like factor 7

    RNA

    1. NR_073108.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate 5' exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC008062, DA023826

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      207074137..207173851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047446149.1XP_047302105.1  Krueppel-like factor 7 isoform X3

      UniProtKB/TrEMBL
      Q4ZG79
    2. XM_047446146.1XP_047302102.1  Krueppel-like factor 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
      UniProtKB/TrEMBL
      B3KNE6
    3. XM_047446145.1XP_047302101.1  Krueppel-like factor 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
      UniProtKB/TrEMBL
      B3KNE6
    4. XM_047446147.1XP_047302103.1  Krueppel-like factor 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
      UniProtKB/TrEMBL
      B3KNE6
    5. XM_047446144.1XP_047302100.1  Krueppel-like factor 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
      UniProtKB/TrEMBL
      B3KNE6
    6. XM_017005161.2XP_016860650.1  Krueppel-like factor 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
      UniProtKB/TrEMBL
      B3KNE6
      Conserved Domains (5) summary
      COG5048
      Location:212284
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:224243
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:279301
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:265290
      zf-H2C2_2; Zinc-finger double domain
      cd21585
      Location:2220
      KLF7_N; N-terminal domain of Kruppel-like factor 7
    7. XM_017005164.3XP_016860653.1  Krueppel-like factor 7 isoform X5

      UniProtKB/Swiss-Prot
      O75840
      Related
      ENSP00000515454.1, ENST00000703734.1
    8. XM_047446148.1XP_047302104.1  Krueppel-like factor 7 isoform X2

      UniProtKB/TrEMBL
      Q4ZG79
    9. XM_011512075.3XP_011510377.1  Krueppel-like factor 7 isoform X4

      UniProtKB/TrEMBL
      A0A994J6Y4
      Conserved Domains (2) summary
      sd00017
      Location:221243
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:219243
      zf-C2H2; Zinc finger, C2H2 type
    10. XM_047446150.1XP_047302106.1  Krueppel-like factor 7 isoform X4

      UniProtKB/TrEMBL
      A0A994J6Y4

    RNA

    1. XR_923051.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      207556313..207657581 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344310.1XP_054200285.1  Krueppel-like factor 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
      UniProtKB/TrEMBL
      B3KNE6
    2. XM_054344311.1XP_054200286.1  Krueppel-like factor 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
      UniProtKB/TrEMBL
      B3KNE6
    3. XM_054344313.1XP_054200288.1  Krueppel-like factor 7 isoform X3

      UniProtKB/TrEMBL
      Q4ZG79
    4. XM_054344309.1XP_054200284.1  Krueppel-like factor 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
      UniProtKB/TrEMBL
      B3KNE6
    5. XM_054344308.1XP_054200283.1  Krueppel-like factor 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
      UniProtKB/TrEMBL
      B3KNE6
    6. XM_054344316.1XP_054200291.1  Krueppel-like factor 7 isoform X5

    7. XM_054344312.1XP_054200287.1  Krueppel-like factor 7 isoform X2

      UniProtKB/TrEMBL
      Q4ZG79
    8. XM_054344314.1XP_054200289.1  Krueppel-like factor 7 isoform X4

      UniProtKB/TrEMBL
      A0A994J6Y4
    9. XM_054344315.1XP_054200290.1  Krueppel-like factor 7 isoform X4

      UniProtKB/TrEMBL
      A0A994J6Y4

    RNA

    1. XR_008486574.1 RNA Sequence

    2. XR_008486573.1 RNA Sequence