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    CAV1 caveolin 1 [ Homo sapiens (human) ]

    Gene ID: 857, updated on 19-Jul-2021

    Summary

    Official Symbol
    CAV1provided by HGNC
    Official Full Name
    caveolin 1provided by HGNC
    Primary source
    HGNC:HGNC:1527
    See related
    Ensembl:ENSG00000105974 MIM:601047
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGL3; PPH3; BSCL3; LCCNS; VIP21; MSTP085
    Summary
    The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]
    Expression
    Biased expression in fat (RPKM 322.1), lung (RPKM 308.8) and 13 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CAV1 in Genome Data Viewer
    Location:
    7q31.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (116525009..116561185)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (116165063..116201239)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986838 Neighboring gene greater CFTR locus negative regulatory element CR2 Neighboring gene caveolin 2 Neighboring gene Sharpr-MPRA regulatory region 15503 Neighboring gene Sharpr-MPRA regulatory region 6449 Neighboring gene greater CFTR locus negative regulatory element NR2 Neighboring gene cytosolic oncogenic antisense to MET transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma.
    GeneReviews: Not available
    Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma.
    GeneReviews: Not available
    Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
    GeneReviews: Not available
    Genetic determinants of P wave duration and PR segment.
    GeneReviews: Not available
    Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.
    GeneReviews: Not available
    Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations.
    GeneReviews: Not available
    Genome-wide association study of PR interval.
    GeneReviews: Not available
    Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.
    GeneReviews: Not available
    Lipodystrophy, congenital generalized, type 3
    MedGen: C2675861 OMIM: 612526 GeneReviews: Not available
    Compare labs
    Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
    GeneReviews: Not available
    Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.
    GeneReviews: Not available
    Partial lipodystrophy, congenital cataracts, and neurodegeneration syndrome
    MedGen: C3807567 OMIM: 606721 GeneReviews: Not available
    Compare labs
    Primary pulmonary hypertension 3 Compare labs
    Several common variants modulate heart rate, PR interval and QRS duration.
    GeneReviews: Not available

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of caveolin 1 (CAV1) by siRNA enhances HIV-1 infection in human Langerhans cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 forms a stable complex with caveolin-1 through its amino-acid residues 623-631 in HIV-infected cells; antibodies to the caveolin-1 binding domain in gp41 inhibit virus infectivity PubMed
    env Amino acid residues 61-101 of caveolin 1 are involved in the binding of caveolin 1 to the N36(L8)C34 domain of gp41 PubMed
    Nef nef HIV-1 Nef induces phosphorylation of CAV1 in endothelial cells PubMed
    nef HIV-1 Nef redistributes CAV1 during high density lipoprotein stimulation in human aortic endothelial cells (suggesting that HIV interferes with cholesterol efflux by high density lipoproteins) PubMed
    nef Cav-1 physically interacts with HIV-1 Nef and restores Nef mediated impairment of apoA-I mediated cholesterol efflux in astrocyte derived glioblastoma cells and macrophages PubMed
    Tat tat HIV-1 Tat co-localizes with CAV1 in the cholesterol-enriched lipid rafts of human podocytes PubMed
    tat Activation of p38 MAPK in HIV-infected cells mediated by Tat leads to the phosphorylation of p53 which subsequently upregulates CAV-1 expression PubMed
    tat Treatment with Tat activates the Ras pathway in human brain micro vascular endothelial cells (HBMECs), an effect that is markedly attenuated by caveolin-1 silencing PubMed
    Vpr vpr HIV-1 Vpr C-terminus (residues 52-96) entry into cells is mediated through clathrin- and caveolae/raft-dependent endocytosis PubMed
    capsid gag HIV-1 CA co-localizes with langerin and caveolin-1 at the cell membrane of human Langerhans cells PubMed
    reverse transcriptase gag-pol CAV-1 expression inhibits HIV-1 replication monitored by reverse transcriptase activity PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ATPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cholesterol binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables inward rectifier potassium channel inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables molecular adaptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables nitric-oxide synthase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables patched binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables peptidase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T cell costimulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in angiotensin-activated signaling pathway involved in heart process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in basement membrane organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in caveola assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in caveola assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in caveola assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in caveola assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in caveolin-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to exogenous dsRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to hyperoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to peptide hormone stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to transforming growth factor beta stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cholesterol homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cholesterol homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cholesterol transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in insulin receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lactation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid storage ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in maintenance of protein location in cell ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mammary gland development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mammary gland involution ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in membrane depolarization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of anoikis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endothelial cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of endothelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of inward rectifier potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of necroptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of nitric oxide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of nitric-oxide synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of peptidyl-tyrosine autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of pinocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of potassium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of tyrosine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nitric oxide homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of ER-associated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of calcium ion transport into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of catalytic activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell adhesion molecule production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cholesterol efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gap junction assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of toll-like receptor 3 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vasoconstriction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in posttranscriptional regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to plasma membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor internalization involved in canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in receptor-mediated endocytosis of virus by host cell IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of cell communication by electrical coupling involved in cardiac conduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of entry of bacterium into host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of heart rate by cardiac conduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of membrane repolarization during action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of ruffle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of smooth muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of the force of heart contraction by chemical signal IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of ventricular cardiac muscle cell action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within response to estrogen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to progesterone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in skeletal muscle tissue development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in triglyceride metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vasculogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    located_in acrosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of caveolar macromolecular signaling complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome membrane TAS
    Traceable Author Statement
    more info
     
    located_in endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion HDA PubMed 
    colocalizes_with focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lipid droplet TAS
    Traceable Author Statement
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    caveolin-1
    Names
    caveolin 1, caveolae protein, 22kDa
    cell growth-inhibiting protein 32

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012051.1 RefSeqGene

      Range
      5252..41395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001172895.1NP_001166366.1  caveolin-1 isoform beta

      See identical proteins and their annotated locations for NP_001166366.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (beta) is shorter than isoform alpha. Variants 2, 3 and 4 encode the same isoform.
      Source sequence(s)
      AB209926, AC006159, AK290871, BC006432, BG170208, DB266251
      Consensus CDS
      CCDS55156.1
      UniProtKB/TrEMBL
      A0A024R757, Q2TNI1, Q59E85
      Related
      ENSP00000384348.1, ENST00000405348.6
      Conserved Domains (1) summary
      pfam01146
      Location:14144
      Caveolin
    2. NM_001172896.2NP_001166367.1  caveolin-1 isoform beta

      See identical proteins and their annotated locations for NP_001166367.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (beta) is shorter than isoform alpha. Variants 2, 3 and 4 encode the same isoform.
      Source sequence(s)
      AB209926, AC006159, AF172085, AK290871, BG170208, DA943080
      Consensus CDS
      CCDS55156.1
      UniProtKB/TrEMBL
      A0A024R757, Q2TNI1, Q59E85, Q7Z4F3
      Related
      ENSP00000377110.1, ENST00000393467.1
      Conserved Domains (1) summary
      pfam01146
      Location:14144
      Caveolin
    3. NM_001172897.2NP_001166368.1  caveolin-1 isoform beta

      See identical proteins and their annotated locations for NP_001166368.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (beta) is shorter than isoform alpha. Variants 2, 3 and 4 encode the same isoform.
      Source sequence(s)
      AB209926, AC006159, AK290871, BG170208, DA477166, EF649773
      Consensus CDS
      CCDS55156.1
      UniProtKB/TrEMBL
      A0A024R757, A9XTE5, Q2TNI1, Q59E85
      Related
      ENSP00000377111.1, ENST00000393468.1
      Conserved Domains (1) summary
      pfam01146
      Location:14144
      Caveolin
    4. NM_001753.5NP_001744.2  caveolin-1 isoform alpha

      See identical proteins and their annotated locations for NP_001744.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (alpha).
      Source sequence(s)
      AB209926, AC006159, AK290871, BG170208
      Consensus CDS
      CCDS5767.1
      UniProtKB/Swiss-Prot
      Q03135
      UniProtKB/TrEMBL
      Q2TNI1, Q59E85
      Related
      ENSP00000339191.2, ENST00000341049.7
      Conserved Domains (1) summary
      pfam01146
      Location:45175
      Caveolin

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

      Range
      116525009..116561185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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