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    MADD MAP kinase activating death domain [ Homo sapiens (human) ]

    Gene ID: 8567, updated on 22-Sep-2023

    Summary

    Official Symbol
    MADDprovided by HGNC
    Official Full Name
    MAP kinase activating death domainprovided by HGNC
    Primary source
    HGNC:HGNC:6766
    See related
    Ensembl:ENSG00000110514 MIM:603584; AllianceGenome:HGNC:6766
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DENN; IG20; DEEAH; RabGEF; NEDDISH; RAB3GEP
    Summary
    Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 27.7), testis (RPKM 18.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MADD in Genome Data Viewer
    Location:
    11p11.2
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (47269188..47330031)
    RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (47425958..47486853)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (47290739..47351582)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:47236089-47237288 Neighboring gene damage specific DNA binding protein 2 Neighboring gene acid phosphatase 2, lysosomal Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:47280987-47281555 Neighboring gene nuclear receptor subfamily 1 group H member 3 Neighboring gene Sharpr-MPRA regulatory region 2100 Neighboring gene Sharpr-MPRA regulatory region 9889 Neighboring gene MADD antisense RNA 1 Neighboring gene myosin binding protein C3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:47371915-47372896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:47372897-47373877 Neighboring gene Spi-1 proto-oncogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:47395717-47396218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:47399745-47400696

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Deeah syndrome
    MedGen: C5436579 OMIM: 619004 GeneReviews: Not available
    Compare labs
    Neurodevelopmental disorder with dysmorphic facies, impaired speech, and hypotonia
    MedGen: C5436585 OMIM: 619005 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
    EBI GWAS Catalog
    Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
    EBI GWAS Catalog
    Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
    EBI GWAS Catalog
    New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ35600, FLJ36300, KIAA0358

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    MAP kinase-activating death domain protein
    Names
    Insuloma-Glucagonoma protein 20
    Rab3 GDP/GTP exchange factor
    differentially expressed in normal and neoplastic cells
    insulinoma glucagonoma clone 20
    rab3 GDP/GTP exchange protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029462.2 RefSeqGene

      Range
      5947..65845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001135943.2NP_001129415.1  MAP kinase-activating death domain protein isoform 9

      See identical proteins and their annotated locations for NP_001129415.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR, and uses two alternate in-frame splice sites and lacks three alternate in-frame exons in the mid coding region, compared to variant 4. The resulting isoform (i) is shorter than isoform d.
      Source sequence(s)
      AC018410, AC090582
      UniProtKB/Swiss-Prot
      Q8WXG6
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    2. NM_001135944.2NP_001129416.1  MAP kinase-activating death domain protein isoform 10

      See identical proteins and their annotated locations for NP_001129416.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) uses two alternate in-frame splice sites and lacks three alternate in-frame exons in the mid coding region, compared to variant 4. The resulting isoform (j) is shorter than isoform d.
      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS44589.1
      UniProtKB/Swiss-Prot
      Q8WXG6
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Related
      ENSP00000378753.3, ENST00000395344.7
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    3. NM_001376571.1NP_001363500.1  MAP kinase-activating death domain protein isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PXF1, A0A9L9PYF5
      Related
      ENSP00000516604.1, ENST00000706887.1
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    4. NM_001376572.1NP_001363501.1  MAP kinase-activating death domain protein isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    5. NM_001376573.1NP_001363502.1  MAP kinase-activating death domain protein isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    6. NM_001376574.1NP_001363503.1  MAP kinase-activating death domain protein isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    7. NM_001376575.1NP_001363504.1  MAP kinase-activating death domain protein isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    8. NM_001376576.1NP_001363505.1  MAP kinase-activating death domain protein isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A0U1RR25, A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    9. NM_001376577.1NP_001363506.1  MAP kinase-activating death domain protein isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A0U1RR25, A0A9L9PYF5
      Related
      ENSP00000489300.2, ENST00000634938.2
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    10. NM_001376578.1NP_001363507.1  MAP kinase-activating death domain protein isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (4) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      PHA03132
      Location:717908
      PHA03132; thymidine kinase; Provisional
    11. NM_001376579.1NP_001363508.1  MAP kinase-activating death domain protein isoform 77

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    12. NM_001376580.1NP_001363509.1  MAP kinase-activating death domain protein isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    13. NM_001376581.1NP_001363510.1  MAP kinase-activating death domain protein isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PXZ0, A0A9L9PYF5
      Related
      ENSP00000516602.1, ENST00000706886.1
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    14. NM_001376582.1NP_001363511.1  MAP kinase-activating death domain protein isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    15. NM_001376583.1NP_001363512.1  MAP kinase-activating death domain protein isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    16. NM_001376584.1NP_001363513.1  MAP kinase-activating death domain protein isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS7931.1
      UniProtKB/TrEMBL
      A0A0A0MRB5, A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    17. NM_001376585.1NP_001363514.1  MAP kinase-activating death domain protein isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    18. NM_001376586.1NP_001363515.1  MAP kinase-activating death domain protein isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    19. NM_001376593.1NP_001363522.1  MAP kinase-activating death domain protein isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    20. NM_001376594.1NP_001363523.1  MAP kinase-activating death domain protein isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    21. NM_001376595.1NP_001363524.1  MAP kinase-activating death domain protein isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PXN0, A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    22. NM_001376596.1NP_001363525.1  MAP kinase-activating death domain protein isoform 76

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    23. NM_001376597.1NP_001363526.1  MAP kinase-activating death domain protein isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PXN0, A0A9L9PYF5
      Related
      ENSP00000516606.1, ENST00000706889.1
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    24. NM_001376598.1NP_001363527.1  MAP kinase-activating death domain protein isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    25. NM_001376599.1NP_001363528.1  MAP kinase-activating death domain protein isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PXZ3, A0A9L9PYF5
      Related
      ENSP00000516607.1, ENST00000706890.1
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    26. NM_001376600.1NP_001363529.1  MAP kinase-activating death domain protein isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PXZ3, A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    27. NM_001376601.1NP_001363530.1  MAP kinase-activating death domain protein isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PXZ3, A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    28. NM_001376602.1NP_001363531.1  MAP kinase-activating death domain protein isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    29. NM_001376603.1NP_001363532.1  MAP kinase-activating death domain protein isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    30. NM_001376604.1NP_001363533.1  MAP kinase-activating death domain protein isoform 75

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    31. NM_001376605.1NP_001363534.1  MAP kinase-activating death domain protein isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Related
      ENSP00000516605.1, ENST00000706888.1
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    32. NM_001376606.1NP_001363535.1  MAP kinase-activating death domain protein isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    33. NM_001376607.1NP_001363536.1  MAP kinase-activating death domain protein isoform 32

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    34. NM_001376608.1NP_001363537.1  MAP kinase-activating death domain protein isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    35. NM_001376609.1NP_001363538.1  MAP kinase-activating death domain protein isoform 34

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    36. NM_001376610.1NP_001363539.1  MAP kinase-activating death domain protein isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    37. NM_001376611.1NP_001363540.1  MAP kinase-activating death domain protein isoform 36

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    38. NM_001376612.1NP_001363541.1  MAP kinase-activating death domain protein isoform 37

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    39. NM_001376613.1NP_001363542.1  MAP kinase-activating death domain protein isoform 38

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    40. NM_001376614.1NP_001363543.1  MAP kinase-activating death domain protein isoform 38

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    41. NM_001376615.1NP_001363544.1  MAP kinase-activating death domain protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS44588.1
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    42. NM_001376616.1NP_001363545.1  MAP kinase-activating death domain protein isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS44588.1
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    43. NM_001376617.1NP_001363546.1  MAP kinase-activating death domain protein isoform 39

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    44. NM_001376618.1NP_001363547.1  MAP kinase-activating death domain protein isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS44589.1
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    45. NM_001376619.1NP_001363548.1  MAP kinase-activating death domain protein isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS44589.1
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    46. NM_001376620.1NP_001363549.1  MAP kinase-activating death domain protein isoform 40

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:418486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:430
      uDENN; uDENN domain
    47. NM_001376621.1NP_001363550.1  MAP kinase-activating death domain protein isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS44589.1
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    48. NM_001376622.1NP_001363551.1  MAP kinase-activating death domain protein isoform 41

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    49. NM_001376623.1NP_001363552.1  MAP kinase-activating death domain protein isoform 41

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    50. NM_001376624.1NP_001363553.1  MAP kinase-activating death domain protein isoform 42

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    51. NM_001376625.1NP_001363554.1  MAP kinase-activating death domain protein isoform 42

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    52. NM_001376626.1NP_001363555.1  MAP kinase-activating death domain protein isoform 43

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PY22, A0A9L9PYF5
      Related
      ENSP00000516608.1, ENST00000706891.1
      Conserved Domains (3) summary
      smart00801
      Location:418486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:430
      uDENN; uDENN domain
    53. NM_001376627.1NP_001363556.1  MAP kinase-activating death domain protein isoform 45

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:418486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:430
      uDENN; uDENN domain
    54. NM_001376628.1NP_001363557.1  MAP kinase-activating death domain protein isoform 44

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    55. NM_001376629.1NP_001363558.1  MAP kinase-activating death domain protein isoform 46

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    56. NM_001376630.1NP_001363559.1  MAP kinase-activating death domain protein isoform 46

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    57. NM_001376631.1NP_001363560.1  MAP kinase-activating death domain protein isoform 47

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (4) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      PHA03132
      Location:717908
      PHA03132; thymidine kinase; Provisional
    58. NM_001376632.1NP_001363561.1  MAP kinase-activating death domain protein isoform 48

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    59. NM_001376633.1NP_001363562.1  MAP kinase-activating death domain protein isoform 49

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    60. NM_001376634.1NP_001363563.1  MAP kinase-activating death domain protein isoform 50

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    61. NM_001376635.1NP_001363564.1  MAP kinase-activating death domain protein isoform 51

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:418486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:430
      uDENN; uDENN domain
    62. NM_001376636.1NP_001363565.1  MAP kinase-activating death domain protein isoform 52

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    63. NM_001376637.1NP_001363566.1  MAP kinase-activating death domain protein isoform 52

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    64. NM_001376638.1NP_001363567.1  MAP kinase-activating death domain protein isoform 53

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    65. NM_001376639.1NP_001363568.1  MAP kinase-activating death domain protein isoform 53

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    66. NM_001376640.1NP_001363569.1  MAP kinase-activating death domain protein isoform 54

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    67. NM_001376641.1NP_001363570.1  MAP kinase-activating death domain protein isoform 55

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    68. NM_001376642.1NP_001363571.1  MAP kinase-activating death domain protein isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    69. NM_001376643.1NP_001363572.1  MAP kinase-activating death domain protein isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    70. NM_001376644.1NP_001363573.1  MAP kinase-activating death domain protein isoform 57

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:418486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:430
      uDENN; uDENN domain
    71. NM_001376645.1NP_001363574.1  MAP kinase-activating death domain protein isoform 58

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    72. NM_001376646.1NP_001363575.1  MAP kinase-activating death domain protein isoform 59

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:418486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:430
      uDENN; uDENN domain
    73. NM_001376647.1NP_001363576.1  MAP kinase-activating death domain protein isoform 60

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PY18, A0A9L9PYF5
      Related
      ENSP00000516603.1, ENST00000526603.6
      Conserved Domains (3) summary
      smart00801
      Location:418486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:430
      uDENN; uDENN domain
    74. NM_001376648.1NP_001363577.1  MAP kinase-activating death domain protein isoform 61

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:418486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:430
      uDENN; uDENN domain
    75. NM_001376649.1NP_001363578.1  MAP kinase-activating death domain protein isoform 62

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    76. NM_001376650.1NP_001363579.1  MAP kinase-activating death domain protein isoform 63

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    77. NM_001376651.1NP_001363580.1  MAP kinase-activating death domain protein isoform 64

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    78. NM_001376652.1NP_001363581.1  MAP kinase-activating death domain protein isoform 64

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    79. NM_001376653.1NP_001363582.1  MAP kinase-activating death domain protein isoform 65

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    80. NM_001376654.1NP_001363583.1  MAP kinase-activating death domain protein isoform 66

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:418486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:430
      uDENN; uDENN domain
    81. NM_001376655.1NP_001363584.1  MAP kinase-activating death domain protein isoform 67

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    82. NM_001376656.1NP_001363585.1  MAP kinase-activating death domain protein isoform 78

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    83. NM_001376657.1NP_001363586.1  MAP kinase-activating death domain protein isoform 68

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:418486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:430
      uDENN; uDENN domain
    84. NM_001376658.1NP_001363587.1  MAP kinase-activating death domain protein isoform 69

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    85. NM_001376659.1NP_001363588.1  MAP kinase-activating death domain protein isoform 70

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:418486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:430
      uDENN; uDENN domain
    86. NM_001376660.1NP_001363589.1  MAP kinase-activating death domain protein isoform 71

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:418486
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:105334
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:430
      uDENN; uDENN domain
    87. NM_001376661.1NP_001363590.1  MAP kinase-activating death domain protein isoform 72

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    88. NM_001376662.1NP_001363591.1  MAP kinase-activating death domain protein isoform 73

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    89. NM_001376663.1NP_001363592.1  MAP kinase-activating death domain protein isoform 74

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Conserved Domains (2) summary
      smart00801
      Location:264332
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:28180
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    90. NM_003682.4NP_003673.3  MAP kinase-activating death domain protein isoform 4

      See identical proteins and their annotated locations for NP_003673.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS7930.1
      UniProtKB/Swiss-Prot
      A8K8S7, B5MEE5, D3DQR4, O15065, O15293, Q15732, Q15741, Q8IWD7, Q8WXG3, Q8WXG4, Q8WXG5, Q8WXG6, Q8WZ63
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Related
      ENSP00000310933.4, ENST00000311027.9
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    91. NM_130470.3NP_569826.2  MAP kinase-activating death domain protein isoform 1

      See identical proteins and their annotated locations for NP_569826.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) has a different exon 1 sequence and lacks exons 16, 21 and 26, as compared to transcript variant 4. The resulting isoform (a) is shorter than isoform d.
      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS7931.1
      UniProtKB/Swiss-Prot
      Q8WXG6
      UniProtKB/TrEMBL
      A0A0A0MRB5, A0A9L9PYF5
      Related
      ENSP00000343902.4, ENST00000342922.8
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    92. NM_130471.3NP_569827.2  MAP kinase-activating death domain protein isoform 2

      See identical proteins and their annotated locations for NP_569827.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks exons 21, 26, and a portion of exon 13 as compared to transcript variant 4. The resulting isoform (b) is missing regions of 43 aa, 18 aa, and 21 aa but has identical N- and C-termini as those of isoform (d) encoded by transcript variant 4.
      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS44587.1
      UniProtKB/Swiss-Prot
      Q8WXG6
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Related
      ENSP00000384204.3, ENST00000407859.7
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    93. NM_130472.3NP_569828.2  MAP kinase-activating death domain protein isoform 3

      See identical proteins and their annotated locations for NP_569828.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks exons 16, 21, 26, and a portion of exon 13 as compared to transcript variant 4. The resulting isoform (c) is missing regions of 43 aa, 20 aa, 18 aa, and 21 aa but has identical N- and C-termini as those of isoform (d) encoded by transcript variant 4.
      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS44588.1
      UniProtKB/Swiss-Prot
      Q8WXG6
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Related
      ENSP00000385585.1, ENST00000402799.5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    94. NM_130473.3NP_569829.2  MAP kinase-activating death domain protein isoform 5

      See identical proteins and their annotated locations for NP_569829.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks exons 21 and 26 as compared to transcript variant 4. The resulting isoform (e) is missing regions of 18 aa and 21 aa but has identical N- and C-termini as those of isoform (d) encoded by transcript variant 4.
      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS7932.1
      UniProtKB/Swiss-Prot
      Q8WXG6
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Related
      ENSP00000304505.6, ENST00000349238.7
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    95. NM_130474.3NP_569830.2  MAP kinase-activating death domain protein isoform 6

      See identical proteins and their annotated locations for NP_569830.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks exons 16, 21, 26, 34, and part of exon 13 but maintains the same reading frame up through exon 33 as compared to transcript variant 4. The resulting isoform (f) is missing regions of 43 aa, 20 aa, 18 aa, and 21 aa and has a different carboxyl terminus as compared to isoform d.
      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS44590.1
      UniProtKB/Swiss-Prot
      Q8WXG6
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Related
      ENSP00000384435.1, ENST00000406482.5
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    96. NM_130475.3NP_569831.1  MAP kinase-activating death domain protein isoform 7

      See identical proteins and their annotated locations for NP_569831.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has a different exon 1 sequence and lacks exon 34 as compared to transcript variant 4. The resulting isoform (g) is shorter and has a different carboxyl terminus as compared to the isoform (d) encoded by transcript variant 4.
      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS41642.1
      UniProtKB/Swiss-Prot
      Q8WXG6
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Related
      ENSP00000378745.3, ENST00000395336.7
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    97. NM_130476.3NP_569832.2  MAP kinase-activating death domain protein isoform 8

      See identical proteins and their annotated locations for NP_569832.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) has a different exon 1 sequence, lacks exons 16, 21 and 26, and uses an alternate in-frame splice site in exon 23, as compared to transcript variant 4. The resulting isoform (h) is shorter than isoform d.
      Source sequence(s)
      AC018410, AC090582
      Consensus CDS
      CCDS44586.1
      UniProtKB/Swiss-Prot
      Q8WXG6
      UniProtKB/TrEMBL
      A0A9L9PYF5
      Related
      ENSP00000384287.2, ENST00000402192.6
      Conserved Domains (3) summary
      smart00801
      Location:486554
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:173402
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:898
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    RNA

    1. NR_164835.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
    2. NR_164836.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
    3. NR_164837.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
    4. NR_164838.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
    5. NR_164839.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
    6. NR_164840.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
    7. NR_164841.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582
    8. NR_164842.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018410, AC090582

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      47269188..47330031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      47425958..47486853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)