FMS1 polyamine oxidase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: FMS1
Official Full Name: polyamine oxidase
Primary source: SGD:S000004622
Locus tag: YMR020W
See related: AllianceGenome:SGD:S000004622; FungiDB:YMR020W; VEuPathDB:YMR020W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables polyamine oxidase activity. Involved in pantothenate biosynthetic process and spermine catabolic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including Brunner Syndrome; alcohol use disorder; autism spectrum disorder; lung non-small cell carcinoma; and panic disorder. Orthologous to several human genes including PAOX (polyamine oxidase) and SMOX (spermine oxidase). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The results are consistent with the role of Asn195 and Asp94 being to properly position the polyamine substrate for oxidation.
Title: Mechanistic and structural analyses of the roles of active site residues in yeast polyamine oxidase Fms1: characterization of the N195A and D94N enzymes.
X ray structure; Fms1 consists of an FAD-binding domain, with Rossmann fold topology, and a substrate-binding domain
Title: Crystal structures of Fms1 and its complex with spermine reveal substrate specificity.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity	IEA Inferred from Electronic Annotation more info
enables N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables polyamine oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables polyamine oxidase activity	IEA Inferred from Electronic Annotation more info
enables polyamine oxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables spermine oxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in pantothenate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermine catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in spermine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed

NP_013733.1

Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis