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    CIPC CLOCK interacting pacemaker [ Homo sapiens (human) ]

    Gene ID: 85457, updated on 17-Jun-2024

    Summary

    Official Symbol
    CIPCprovided by HGNC
    Official Full Name
    CLOCK interacting pacemakerprovided by HGNC
    Primary source
    HGNC:HGNC:20365
    See related
    Ensembl:ENSG00000198894 MIM:616995; AllianceGenome:HGNC:20365
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIAA1737
    Summary
    Predicted to be involved in negative regulation of circadian rhythm and negative regulation of transcription, DNA-templated. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 21.3), heart (RPKM 15.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CIPC in Genome Data Viewer
    Location:
    14q24.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (77098258..77117287)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (71308042..71327053)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (77564601..77583630)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2288 Neighboring gene long intergenic non-protein coding RNA 2289 Neighboring gene Sharpr-MPRA regulatory region 8378 Neighboring gene uncharacterized LOC124903350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8789 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5966 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77564243-77565072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8790 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8791 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8793 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8795 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5967 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77600131-77600630 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:77605838-77606387 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77606525-77607088 Neighboring gene zinc finger DHHC-type palmitoyltransferase 22 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77607089-77607652 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:77607747-77608248 Neighboring gene Sharpr-MPRA regulatory region 385 Neighboring gene family with sequence similarity 204 member D, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1737

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    CLOCK-interacting pacemaker
    Names
    CLOCK-interacting circadian protein
    CLOCK-interacting protein, circadian

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033426.3NP_219494.2  CLOCK-interacting pacemaker

      See identical proteins and their annotated locations for NP_219494.2

      Status: VALIDATED

      Source sequence(s)
      AC007375, AC007686
      Consensus CDS
      CCDS9855.1
      UniProtKB/Swiss-Prot
      B2RCI1, Q8N389, Q8NDZ1, Q9C0C6
      Related
      ENSP00000355319.2, ENST00000361786.7
      Conserved Domains (1) summary
      pfam15800
      Location:38376
      CiPC; Clock interacting protein circadian

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      77098258..77117287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      71308042..71327053
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)