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    RGS2 GTPase-activating protein RGS2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854274, updated on 13-Apr-2024

    Summary

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    Gene symbol
    RGS2
    Gene description
    GTPase-activating protein RGS2
    Primary source
    SGD:S000005633
    Locus tag
    YOR107W
    See related
    AllianceGenome:SGD:S000005633
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activator activity. Involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RGS2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (521353..522282)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Pin2p Neighboring gene uncharacterized protein Neighboring gene SNAP receptor VAM3 Neighboring gene 2-isopropylmalate synthase LEU9 Neighboring gene phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Galpha protein dependent and independent effects of human RGS1 expression in yeast. Li XY, et al. Cell Signal, 2004 Jan. PMID 14607274
    2. Mechanisms governing subcellular localization and function of human RGS2. Heximer SP, et al. J Biol Chem, 2001 Apr 27. PMID 11278586
    3. A novel regulator of G protein signalling in yeast, Rgs2, downregulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2. Versele M, et al. EMBO J, 1999 Oct 15. PMID 10523302, Free PMC Article
    4. Regulation of longevity by regulator of G-protein signaling protein, Loco. Lin YR, et al. Aging Cell, 2011 Jun. PMID 21255223
    5. QTL mapping of volatile compound production in Saccharomyces cerevisiae during alcoholic fermentation. Eder M, et al. BMC Genomics, 2018 Mar 1. PMID 29490607, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GTPase-activating protein RGS2
    NP_014750.3
    • Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      521353..522282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183526.3 → NP_014750.3  TPA: GTPase-activating protein RGS2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014750.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2G6, Q99188
      UniProtKB/TrEMBL
      A0A8H4BWZ6, G2WMY2, N1NYE3
      Conserved Domains (1) summary
      cd07440
      Location:42 → 154
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99188.1

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