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    CDC33 translation initiation factor eIF4E [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854026, updated on 2-Nov-2024

    Summary

    Official Symbol
    CDC33
    Official Full Name
    translation initiation factor eIF4E
    Primary source
    SGD:S000005499
    Locus tag
    YOL139C
    See related
    AllianceGenome:SGD:S000005499; FungiDB:YOL139C; VEuPathDB:YOL139C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    TIF45
    Summary
    Enables mRNA cap binding activity and phosphatidylinositol-3-phosphate binding activity. Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; positive regulation of formation of translation preinitiation complex; and regulation of cell cycle. Located in cytoplasmic stress granule and nucleus. Part of eukaryotic translation initiation factor 4F complex. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autism spectrum disorder and autistic disorder. Orthologous to several human genes including EIF4E (eukaryotic translation initiation factor 4E). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See CDC33 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (60383..61024, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase PPM2 Neighboring gene acetylornithine transaminase Neighboring gene Rtc1p Neighboring gene Bsc6p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA cap binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of formation of translation preinitiation complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic stress granule HDA PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of eukaryotic translation initiation factor 4F complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    translation initiation factor eIF4E
    NP_014502.1
    • Translation initiation factor eIF4E; mRNA cap binding protein and subunit of the mRNA cap-binding complex (eIF4F) along with eIF4A (Tif1p/Tif2p) and eIF4G (Tif4631p/Tif4632p), that mediates cap-dependent translation; required with eIF4G for Ded1p-mediated stimulation of mRNA recruitment during 48S preinitiation complex (PIC) assembly; protein abundance increases in response to DNA replication stress; human homolog EIF4E can complement the cdc33 null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      60383..61024 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183393.1NP_014502.1  TPA: translation initiation factor eIF4E [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014502.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1T0, P07260
      UniProtKB/TrEMBL
      A6ZN73, B3LIS8, B5VRC2, C7GV14, C8ZHH8, G2WM99, N1NWK0
      Conserved Domains (1) summary
      COG5053
      Location:1213
      CDC33; Translation initiation factor 4E (eIF-4E) [Translation, ribosomal structure and biogenesis]