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    MPP10 rRNA-processing protein MPP10 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853458, updated on 29-Jun-2024

    Summary

    Gene symbol
    MPP10
    Gene description
    rRNA-processing protein MPP10
    Primary source
    FungiDB:YJR002W
    Locus tag
    YJR002W
    See related
    SGD:S000003762; AllianceGenome:SGD:S000003762; VEuPathDB:YJR002W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of Mpp10 complex and small-subunit processome. Orthologous to human MPHOSPH10 (M-phase phosphoprotein 10). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See MPP10 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (438865..440646)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene proteasome core particle subunit beta 1 Neighboring gene Avt1p Neighboring gene Mrx12p Neighboring gene Sag1p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    part_of 90S preribosome HDA PubMed 
    part_of Mpp10 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Mpp10 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Mpp10 complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus HDA PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of small-subunit processome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of sno(s)RNA-containing ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rRNA-processing protein MPP10
    NP_012535.3
    • Component of the SSU processome and 90S preribosome; required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      438865..440646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181659.3NP_012535.3  TPA: rRNA-processing protein MPP10 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012535.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWH6, P47083
      UniProtKB/TrEMBL
      A0A8H4BZM9, G2WH11, N1P1F8
      Conserved Domains (1) summary
      COG5384
      Location:1593
      Mpp10; U3 small nucleolar ribonucleoprotein component [Translation, ribosomal structure and biogenesis]