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    Kars lysyl-tRNA synthetase [ Mus musculus (house mouse) ]

    Gene ID: 85305, updated on 23-Jun-2021

    Summary

    Official Symbol
    Karsprovided by MGI
    Official Full Name
    lysyl-tRNA synthetaseprovided by MGI
    Primary source
    MGI:MGI:1934754
    See related
    Ensembl:ENSMUSG00000031948
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L; Kars1; LysRS; AA589550; AL024334; AL033315; AL033367; D8Wsu108; D8Ertd698; D8Wsu108e; mKIAA0070; D8Ertd698e
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 43.4), placenta adult (RPKM 35.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kars in Genome Data Viewer
    Location:
    8 E1; 8 58.27 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (112720071..112737986, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111993439..112011354, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (114517340..114535205, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid (GABA) A receptor-associated protein-like 2 Neighboring gene adenosine deaminase, tRNA-specific 1 Neighboring gene telomeric repeat binding factor 2, interacting protein Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene 9564

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATP adenylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables amino acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lysine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lysine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in basophil activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in basophil activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in diadenosine tetraphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in diadenosine tetraphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lysyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in lysyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inflammatory response to antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of macrophage activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to X-ray ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of aminoacyl-tRNA synthetase multienzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of aminoacyl-tRNA synthetase multienzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    lysine--tRNA ligase
    NP_001124340.1
    NP_001273313.1
    NP_001350358.1
    NP_001350359.1
    NP_444322.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130868.2NP_001124340.1  lysine--tRNA ligase isoform 1

      See identical proteins and their annotated locations for NP_001124340.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Variants 1, 3, 4, and 5 all encode the same isoform (1).
      Source sequence(s)
      AC114648, AK167693, W77297
      Consensus CDS
      CCDS52677.1
      UniProtKB/TrEMBL
      Q3TIV6, Q8R2P8
      Related
      ENSMUSP00000090808.6, ENSMUST00000093120.13
      Conserved Domains (1) summary
      PLN02502
      Location:42604
      PLN02502; lysyl-tRNA synthetase
    2. NM_001286384.1NP_001273313.1  lysine--tRNA ligase isoform 1

      See identical proteins and their annotated locations for NP_001273313.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. Variants 1, 3, 4, and 5 all encode the same isoform (1).
      Source sequence(s)
      AC114648, AK167693, W77297
      Consensus CDS
      CCDS52677.1
      UniProtKB/TrEMBL
      Q3TIV6, Q8R2P8
      Related
      ENSMUSP00000126268.2, ENSMUST00000164470.3
      Conserved Domains (1) summary
      PLN02502
      Location:42604
      PLN02502; lysyl-tRNA synthetase
    3. NM_001363429.1NP_001350358.1  lysine--tRNA ligase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. Variants 1, 3, 4, and 5 all encode the same isoform (1).
      Source sequence(s)
      AC114648
      Consensus CDS
      CCDS52677.1
      Conserved Domains (1) summary
      PLN02502
      Location:42604
      PLN02502; lysyl-tRNA synthetase
    4. NM_001363430.1NP_001350359.1  lysine--tRNA ligase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longer isoform (1). Variants 1, 3, 4, and 5 all encode the same isoform (1).
      Source sequence(s)
      AC114648
      Consensus CDS
      CCDS52677.1
      Conserved Domains (1) summary
      PLN02502
      Location:42604
      PLN02502; lysyl-tRNA synthetase
    5. NM_053092.3NP_444322.1  lysine--tRNA ligase isoform 2

      See identical proteins and their annotated locations for NP_444322.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 4. The resulting isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AC114648, AK167693, W77297
      Consensus CDS
      CCDS40481.1
      UniProtKB/Swiss-Prot
      Q99MN1
      UniProtKB/TrEMBL
      Q3TIV6
      Related
      ENSMUSP00000034426.7, ENSMUST00000034426.14
      Conserved Domains (4) summary
      PLN02502
      Location:12575
      PLN02502; lysyl-tRNA synthetase
      cd00775
      Location:235573
      LysRS_core; Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three ...
      cd04322
      Location:123232
      LysRS_N; LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...
      pfam08496
      Location:1445
      Peptidase_S49_N; Peptidase family S49 N-terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      112720071..112737986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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