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    MMP23B matrix metallopeptidase 23B [ Homo sapiens (human) ]

    Gene ID: 8510, updated on 2-May-2024

    Summary

    Official Symbol
    MMP23Bprovided by HGNC
    Official Full Name
    matrix metallopeptidase 23Bprovided by HGNC
    Primary source
    HGNC:HGNC:7171
    See related
    Ensembl:ENSG00000189409 MIM:603321; AllianceGenome:HGNC:7171
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIFR; MMP22; MIFR-1; MMP23A
    Summary
    This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the more telomeric copy of the duplicated region. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in placenta (RPKM 4.1), prostate (RPKM 3.5) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MMP23B in Genome Data Viewer
    Location:
    1p36.33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1632173..1634654)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (1066677..1069155)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1567552..1570030)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1534669-1535328 Neighboring gene uncharacterized LOC105378586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1535329-1535988 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1535989-1536648 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1537005-1537147 Neighboring gene fibronectin type III domain containing 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 83 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 84 Neighboring gene MIB E3 ubiquitin protein ligase 2 Neighboring gene uncharacterized LOC124903821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1565596-1566158 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1568259-1569070 Neighboring gene cyclin dependent kinase 11B Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1590308-1591030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30 Neighboring gene solute carrier family 35 member E2B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1601211-1601711 Neighboring gene ribosomal protein S7 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metalloendopeptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables metallopeptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular matrix NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    matrix metalloproteinase-23
    Names
    MMP-21
    MMP-22
    MMP-23
    femalysin
    matrix metalloproteinase 22
    matrix metalloproteinase 23B
    matrix metalloproteinase in the female reproductive tract
    matrix metalloproteinase-21

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006983.2NP_008914.1  matrix metalloproteinase-23 precursor

      See identical proteins and their annotated locations for NP_008914.1

      Status: REVIEWED

      Source sequence(s)
      AJ005256, FO704657
      Consensus CDS
      CCDS30559.1
      UniProtKB/Swiss-Prot
      A2AGN0, A2AGN1, O75894, O75895, O75900, Q5QPQ8, Q76P96, Q7LDM6, Q7LDM7, Q9UBR9, Q9UJK8
      Related
      ENSP00000348308.5, ENST00000356026.10
      Conserved Domains (3) summary
      smart00408
      Location:313373
      IGc2; Immunoglobulin C-2 Type
      smart00254
      Location:255289
      ShKT; ShK toxin domain
      cd04278
      Location:87254
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      1632173..1634654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432838.1XP_047288794.1  matrix metalloproteinase-23 isoform X2

    2. XM_047432837.1XP_047288793.1  matrix metalloproteinase-23 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      1066677..1069155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339292.1XP_054195267.1  matrix metalloproteinase-23 isoform X2

    2. XM_054339291.1XP_054195266.1  matrix metalloproteinase-23 isoform X1