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    FIZ1 FLT3 interacting zinc finger 1 [ Homo sapiens (human) ]

    Gene ID: 84922, updated on 5-Mar-2024

    Summary

    Official Symbol
    FIZ1provided by HGNC
    Official Full Name
    FLT3 interacting zinc finger 1provided by HGNC
    Primary source
    HGNC:HGNC:25917
    See related
    Ensembl:ENSG00000179943 MIM:609133; AllianceGenome:HGNC:25917
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF798
    Summary
    This gene encodes zinc finger protein, which interacts with a receptor tyrosine kinase involved in the regulation of hematopoietic and lymphoid cells. This gene product also interacts with a transcription factor that regulates the expression of rod-specific genes in retina. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 2.2), brain (RPKM 1.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FIZ1 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55591376..55599517, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58687310..58695453, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56102742..56110883, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56056311-56057147 Neighboring gene Sharpr-MPRA regulatory region 14522 Neighboring gene SH3 domain binding kinase family member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56064283-56064783 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11043 Neighboring gene Sharpr-MPRA regulatory region 13032 Neighboring gene zinc finger protein 579 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11045 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:56110254-56111128 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:56111129-56112002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:56113981-56114531 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:56115635-56116186 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:56116187-56116738 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11048 Neighboring gene zinc finger protein 524 Neighboring gene zinc finger protein 865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15098

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ00416, FLJ14768

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor tyrosine kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    flt3-interacting zinc finger protein 1
    Names
    zinc finger protein 798

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052830.1 RefSeqGene

      Range
      7454..15595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_032836.3NP_116225.2  flt3-interacting zinc finger protein 1

      See identical proteins and their annotated locations for NP_116225.2

      Status: REVIEWED

      Source sequence(s)
      AA864884, AC008735, AK027674, BC132777
      Consensus CDS
      CCDS12928.1
      UniProtKB/Swiss-Prot
      A2RU72, Q6ZMJ7, Q96SL8
      Related
      ENSP00000221665.2, ENST00000221665.5
      Conserved Domains (3) summary
      sd00017
      Location:416436
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:470492
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:428453
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      55591376..55599517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005259352.5XP_005259409.1  flt3-interacting zinc finger protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005259409.1

      UniProtKB/Swiss-Prot
      A2RU72, Q6ZMJ7, Q96SL8
      Conserved Domains (3) summary
      sd00017
      Location:416436
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:470492
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:428453
      zf-H2C2_2; Zinc-finger double domain
    2. XM_047439564.1XP_047295520.1  flt3-interacting zinc finger protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A2RU72, Q6ZMJ7, Q96SL8
    3. XM_011527426.3XP_011525728.2  flt3-interacting zinc finger protein 1 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      58687310..58695453 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322432.1XP_054178407.1  flt3-interacting zinc finger protein 1 isoform X1

    2. XM_054322431.1XP_054178406.1  flt3-interacting zinc finger protein 1 isoform X1

    3. XM_054322433.1XP_054178408.1  flt3-interacting zinc finger protein 1 isoform X2