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    AIFM2 AIF family member 2 [ Homo sapiens (human) ]

    Gene ID: 84883, updated on 27-Nov-2024

    Summary

    Official Symbol
    AIFM2provided by HGNC
    Official Full Name
    AIF family member 2provided by HGNC
    Primary source
    HGNC:HGNC:21411
    See related
    Ensembl:ENSG00000042286 MIM:605159; AllianceGenome:HGNC:21411
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AMID; FSP1; PRG3
    Summary
    This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010]
    Expression
    Broad expression in fat (RPKM 26.6), thyroid (RPKM 7.3) and 22 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See AIFM2 in Genome Data Viewer
    Location:
    10q22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (70112271..70132825, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (70981272..71001807, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (71872027..71892581, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene collagen type XIII alpha 1 chain Neighboring gene uncharacterized LOC107984242 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2438 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:71721094-71721594 Neighboring gene long intergenic non-protein coding RNA 2636 Neighboring gene macroH2A.2 histone Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:71830815-71831314 Neighboring gene HNF4 motif-containing MPRA enhancer 70 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3495 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:71892372-71892872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:71898399-71898899 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3496 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2441 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:71916030-71916530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3497 Neighboring gene trypsin like peroxisomal matrix peptidase 1 Neighboring gene secretion associated Ras related GTPase 1A Neighboring gene calmodulin 2 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp686L1298

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space HDA PubMed 
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ferroptosis suppressor protein 1
    Names
    apoptosis inducing factor mitochondria associated 2
    apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death
    apoptosis-inducing factor 2
    apoptosis-inducing factor, mitochondrion-associated, 2
    ferroptosis suppressor 1
    p53-responsive gene 3 protein
    NP_001185625.1
    NP_116186.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198696.2NP_001185625.1  ferroptosis suppressor protein 1

      See identical proteins and their annotated locations for NP_001185625.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI922797, AL731540, BC023601, BP331371
      Consensus CDS
      CCDS7297.1
      UniProtKB/Swiss-Prot
      B3KXI0, Q63Z39, Q9BRQ8
      Related
      ENSP00000478931.1, ENST00000613322.4
      Conserved Domains (1) summary
      cl26176
      Location:39356
      NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]
    2. NM_032797.6NP_116186.1  ferroptosis suppressor protein 1

      See identical proteins and their annotated locations for NP_116186.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI922797, AL731540, BC023601, BG332787
      Consensus CDS
      CCDS7297.1
      UniProtKB/Swiss-Prot
      B3KXI0, Q63Z39, Q9BRQ8
      Related
      ENSP00000312370.1, ENST00000307864.3
      Conserved Domains (1) summary
      cl26176
      Location:39356
      NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      70112271..70132825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      70981272..71001807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)