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    IL17RC interleukin 17 receptor C [ Homo sapiens (human) ]

    Gene ID: 84818, updated on 8-Jul-2021

    Summary

    Official Symbol
    IL17RCprovided by HGNC
    Official Full Name
    interleukin 17 receptor Cprovided by HGNC
    Primary source
    HGNC:HGNC:18358
    See related
    Ensembl:ENSG00000163702 MIM:610925
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CANDF9; IL17RL; IL17-RL
    Summary
    This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]
    Expression
    Ubiquitous expression in prostate (RPKM 15.4), skin (RPKM 9.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See IL17RC in Genome Data Viewer
    Location:
    3p25.3; 3p25.3-p24.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (9917098..9933627)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9958782..9975305)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 14744 Neighboring gene interleukin 17 receptor E Neighboring gene RNA, U6 small nuclear 882, pseudogene Neighboring gene cysteine rich with EGF like domains 1 Neighboring gene PRRT3 antisense RNA 1 Neighboring gene 3p25 PRRT3 Alu-mediated recombination region Neighboring gene proline rich transmembrane protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ95963, FLJ96005, MGC10763

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables interleukin-17 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables interleukin-17 receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    interleukin-17 receptor C
    Names
    IL-17 receptor C
    IL-17RL
    IL17F receptor
    IL17Rhom
    interleukin-17 receptor homolog
    interleukin-17 receptor-like protein
    zcytoR14

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029376.2 RefSeqGene

      Range
      5001..21524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1311

    mRNA and Protein(s)

    1. NM_001203263.2NP_001190192.2  interleukin-17 receptor C isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks the penultimate coding exon compared to variant 1, however, maintains the reading frame. This results in a shorter isoform (4) missing a protein segment in the C-terminal region compared to isoform 1.
      Source sequence(s)
      AC018809
      Consensus CDS
      CCDS56240.1
      Related
      ENSP00000396064.1, ENST00000413608.2
      Conserved Domains (2) summary
      pfam08357
      Location:506653
      SEFIR; SEFIR domain
      pfam15037
      Location:71459
      IL17_R_N; Interleukin-17 receptor extracellular region
    2. NM_001203264.2NP_001190193.2  interleukin-17 receptor C isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks 2 in-frame coding exons (exon 12 and penultimate exon) compared to variant 1, resulting in a shorter isoform (5, also known as IL-17RCdelta12) missing 2 internal protein segments compared to isoform 1. It has been reported that isoforms lacking exon 12 lose the ability to bind cytokines, IL-17A and IL-17F (PMID:17911633).
      Source sequence(s)
      AC018809
      Consensus CDS
      CCDS74898.1
      Related
      ENSP00000395315.3, ENST00000416074.6
      Conserved Domains (3) summary
      pfam08357
      Location:489636
      SEFIR; SEFIR domain
      pfam15037
      Location:71442
      IL17_R_N; Interleukin-17 receptor extracellular region
      pfam17243
      Location:632668
      POTRA_TamA_1; POTRA domain TamA domain 1
    3. NM_001203265.2NP_001190194.2  interleukin-17 receptor C isoform 6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks 2 in-frame coding exons (exons 7 and 12) compared to variant 1, resulting in a shorter isoform (6, also known as IL-17RCdelta7,12) missing 2 internal protein segments compared to isoform 1. It has been reported that isoforms lacking exon 12 lose the ability to bind cytokines, IL-17A and IL-17F (PMID:17911633).
      Source sequence(s)
      AC018809
      Consensus CDS
      CCDS56241.1
      Related
      ENSP00000407894.1, ENST00000455057.5
      Conserved Domains (2) summary
      pfam08357
      Location:487634
      SEFIR; SEFIR domain
      pfam15037
      Location:71427
      IL17_R_N; Interleukin-17 receptor extracellular region
    4. NM_001367278.1NP_001354207.1  interleukin-17 receptor C isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AC018809
      Conserved Domains (2) summary
      pfam08357
      Location:493640
      SEFIR; SEFIR domain
      pfam15037
      Location:71446
      IL17_R_N; Interleukin-17 receptor extracellular region
    5. NM_001367279.1NP_001354208.1  interleukin-17 receptor C isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AC018809
      Conserved Domains (2) summary
      pfam08357
      Location:466613
      SEFIR; SEFIR domain
      pfam15037
      Location:71419
      IL17_R_N; Interleukin-17 receptor extracellular region
    6. NM_001367280.1NP_001354209.1  interleukin-17 receptor C isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AC018809
      Related
      ENST00000483582.5
      Conserved Domains (2) summary
      pfam08357
      Location:491638
      SEFIR; SEFIR domain
      pfam15037
      Location:71444
      IL17_R_N; Interleukin-17 receptor extracellular region
    7. NM_032732.6NP_116121.3  interleukin-17 receptor C isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame coding exon (exon 7) compared to variant 1, resulting in a shorter isoform (3, also known as IL-17RCdelta7) missing an internal protein segment compared to isoform 1. It has been reported that isoform lacking exon 7 retains the ability to bind cytokines, IL-17A and IL-17F (PMID:17911633).
      Source sequence(s)
      AC018809
      Consensus CDS
      CCDS2591.2
      Related
      ENSP00000373323.4, ENST00000383812.9
      Conserved Domains (2) summary
      pfam08357
      Location:504651
      SEFIR; SEFIR domain
      pfam15037
      Location:71444
      IL17_R_N; Interleukin-17 receptor extracellular region
    8. NM_153460.4NP_703190.2  interleukin-17 receptor C isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript containing all the coding exons, and encodes isoform 1 (also known as IL-17RCFL).
      Source sequence(s)
      AC018809, AF458065, AK096824, AK225650, AY358840, DC381087
      Consensus CDS
      CCDS46746.1
      Related
      ENSP00000384969.3, ENST00000403601.8
      Conserved Domains (2) summary
      pfam08357
      Location:519666
      SEFIR; SEFIR domain
      pfam15037
      Location:71459
      IL17_R_N; Interleukin-17 receptor extracellular region
    9. NM_153461.4NP_703191.2  interleukin-17 receptor C isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate donor splice site at the 5' terminal coding exon compared to variant 1, resulting in a longer isoform (2) containing an additional protein segment compared to isoform 1.
      Source sequence(s)
      AC018809
      Consensus CDS
      CCDS2590.1
      Related
      ENSP00000295981.3, ENST00000295981.7
      Conserved Domains (2) summary
      pfam08357
      Location:590737
      SEFIR; SEFIR domain
      pfam15037
      Location:142530
      IL17_R_N; Interleukin-17 receptor extracellular region

    RNA

    1. NR_037807.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks exon 7 and is alternatively spliced in the mid-coding region compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC018809
      Related
      ENST00000466046.5

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      9917098..9933627
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007327.1XP_016862816.1  interleukin-17 receptor C isoform X2

    2. XM_017007329.1XP_016862818.1  interleukin-17 receptor C isoform X4

    3. XM_017007336.1XP_016862825.1  interleukin-17 receptor C isoform X12

    4. XM_024453793.1XP_024309561.1  interleukin-17 receptor C isoform X10

      Conserved Domains (2) summary
      pfam08357
      Location:562709
      SEFIR; SEFIR domain
      pfam15037
      Location:142515
      IL17_R_N; Interleukin-17 receptor extracellular region
    5. XM_017007339.1XP_016862828.1  interleukin-17 receptor C isoform X15

    6. XM_017007338.1XP_016862827.1  interleukin-17 receptor C isoform X14

    7. XM_017007326.1XP_016862815.1  interleukin-17 receptor C isoform X1

    8. XM_017007333.1XP_016862822.1  interleukin-17 receptor C isoform X8

    9. XM_017007328.1XP_016862817.1  interleukin-17 receptor C isoform X3

    10. XM_017007330.1XP_016862819.1  interleukin-17 receptor C isoform X5

    11. XM_017007331.1XP_016862820.1  interleukin-17 receptor C isoform X6

    12. XM_017007332.1XP_016862821.1  interleukin-17 receptor C isoform X7

    13. XM_017007335.1XP_016862824.1  interleukin-17 receptor C isoform X11

    14. XM_024453794.1XP_024309562.1  interleukin-17 receptor C isoform X16

      Conserved Domains (2) summary
      pfam08357
      Location:545692
      SEFIR; SEFIR domain
      pfam15037
      Location:142485
      IL17_R_N; Interleukin-17 receptor extracellular region
    15. XM_017007334.1XP_016862823.1  interleukin-17 receptor C isoform X9

    16. XM_017007337.1XP_016862826.1  interleukin-17 receptor C isoform X13

    17. XM_017007340.2XP_016862829.1  interleukin-17 receptor C isoform X17

    18. XM_017007341.2XP_016862830.1  interleukin-17 receptor C isoform X18

    19. XM_017007345.2XP_016862834.1  interleukin-17 receptor C isoform X22

    20. XM_017007348.2XP_016862837.1  interleukin-17 receptor C isoform X25

    21. XM_017007342.1XP_016862831.1  interleukin-17 receptor C isoform X19

    22. XM_017007343.1XP_016862832.1  interleukin-17 receptor C isoform X20

    23. XM_017007347.1XP_016862836.1  interleukin-17 receptor C isoform X24

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_153462.1: Suppressed sequence

      Description
      NM_153462.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and because it is a nonsense-mediated mRNA decay (NMD) candidate.
    2. NM_153463.1: Suppressed sequence

      Description
      NM_153463.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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