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    POFUT3 protein O-fucosyltransferase 3 [ Homo sapiens (human) ]

    Gene ID: 84750, updated on 3-Mar-2026
    Official Symbol
    POFUT3provided by HGNC
    Official Full Name
    protein O-fucosyltransferase 3provided by HGNC
    Primary source
    HGNC:HGNC:19234
    See related
    Ensembl:ENSG00000172728 MIM:616931; AllianceGenome:HGNC:19234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FUCTX; FUT10
    Summary
    Enables fucosyltransferase activity. Involved in N-glycan fucosylation. Located in Golgi apparatus; endoplasmic reticulum; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
    Expression
    Ubiquitous expression in ovary (RPKM 2.0), placenta (RPKM 1.5) and 25 other tissues See more
    Orthologs
    all
    Try the new Gene page
    Try the new Transcripts and proteins table
    See POFUT3 in Genome Data Viewer
    Location:
    8p12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (33308061..33473146, complement)
    RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (33578178..33744498, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (33228342..33330664, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379362 Neighboring gene MT-ND2 pseudogene 32 Neighboring gene RAN pseudogene 9 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:32986477-32987676 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:33201768-33202321 Neighboring gene NANOG hESC enhancer GRCh37_chr8:33210014-33210633 Neighboring gene RNA, U6 small nuclear 528, pseudogene Neighboring gene RNA binding motif protein 4 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19094 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19096 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:33341856-33342492 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:33342520-33342707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27220 Neighboring gene small nucleolar RNA, C/D box 13 Neighboring gene MAK16 homolog Neighboring gene TELO2 interacting protein 2

    Go to nucleotide: Graphics FASTA GenBank

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Related articles in PubMed

    1. Comparison of human and mouse Fuc-TX and Fuc-TXI genes, and expression studies in the mouse. Baboval T, et al. Mamm Genome, 2002 Sep. PMID 12370785
    2. FUT10 and FUT11 are protein O-fucosyltransferases that modify protein EMI domains. Hao H, et al. Nat Chem Biol, 2025 Apr. PMID 39775168, Free PMC Article
    3. Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11). Mollicone R, et al. J Biol Chem, 2009 Feb 13. PMID 19088067
    4. Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. Roos C, et al. J Biol Chem, 2002 Feb 1. PMID 11698403
    5. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Liu C, et al. Cancer Res, 2019 May 1. PMID 30862715, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Comparison of human and mouse Fuc-TX and Fuc-TXI genes, and expression studies in the mouse.
      Title: Comparison of human and mouse Fuc-TX and Fuc-TXI genes, and expression studies in the mouse.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    3. Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11).
      Title: Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11).
    Submit: New GeneRIF Correction

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC11141

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alpha-(1->3)-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-(1->3)-fucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-(1->3)-fucosyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables fucosyltransferase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables fucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-O-fucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide-O-fucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-fucose catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in N-glycan processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in N-glycan processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fertilization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in glycoprotein biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycoprotein biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in hemopoiesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in nervous system development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in neuronal stem cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuronal stem cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein O-linked glycosylation TAS
    Traceable Author Statement
    more info
    		  
    involved_in protein O-linked glycosylation via fucose IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein targeting NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in wound healing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    GDP-fucose protein O-fucosyltransferase 3
    Names
    alpha (1,3) fucosyltransferase
    alpha 1,3-fucosyl transferase
    alpha-(1,3)-fucosyltransferase 10
    fuc-TX
    fucT-X
    fucosyltransferase 10
    fucosyltransferase X
    galactoside 3-L-fucosyltransferase 10
    NP_116053.3
    XP_011542978.1
    XP_011542979.1
    XP_011542981.1
    XP_011542982.1
    XP_011542983.1
    XP_047278281.1
    XP_047278282.1
    XP_054217345.1
    XP_054217346.1
    XP_054217347.1
    XP_054217348.1
    XP_054217349.1
    XP_054217350.1
    XP_054217351.1

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032664.3 → NP_116053.3  GDP-fucose protein O-fucosyltransferase 3

      See identical proteins and their annotated locations for NP_116053.3

      Status: VALIDATED

      Source sequence(s)
      AJ582015, BC063462
      Consensus CDS
      CCDS6088.1
      UniProtKB/Swiss-Prot
      A8KAC8, Q6P4F1, Q70GG3, Q8IVI6, Q8IVI7, Q8IVJ3, Q8TE43, Q9BSR3
      UniProtKB/TrEMBL
      B4DLS4
      Related
      ENSP00000332757.5, ENST00000327671.10
      Conserved Domains (2) summary
      pfam00852
      Location:219 → 354
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:83 → 177
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      33308061..33473146 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544677.4 → XP_011542979.1  GDP-fucose protein O-fucosyltransferase 3 isoform X2

      UniProtKB/TrEMBL
      B4DLS4
      Conserved Domains (2) summary
      pfam00852
      Location:219 → 354
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:83 → 177
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    2. XM_011544676.4 → XP_011542978.1  GDP-fucose protein O-fucosyltransferase 3 isoform X1

      UniProtKB/TrEMBL
      B4DLS4
      Conserved Domains (2) summary
      pfam00852
      Location:261 → 396
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:125 → 219
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    3. XM_047422325.1 → XP_047278281.1  GDP-fucose protein O-fucosyltransferase 3 isoform X3

      UniProtKB/TrEMBL
      B4DLS4

    4. XM_011544681.4 → XP_011542983.1  GDP-fucose protein O-fucosyltransferase 3 isoform X6

      UniProtKB/TrEMBL
      B4DLS4
      Conserved Domains (2) summary
      pfam00852
      Location:261 → 396
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:125 → 219
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    5. XM_047422326.1 → XP_047278282.1  GDP-fucose protein O-fucosyltransferase 3 isoform X7

      UniProtKB/TrEMBL
      B4DLS4

    6. XM_011544679.4 → XP_011542981.1  GDP-fucose protein O-fucosyltransferase 3 isoform X4

      UniProtKB/TrEMBL
      B4DLS4
      Conserved Domains (2) summary
      pfam00852
      Location:261 → 396
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:125 → 219
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    7. XM_011544680.4 → XP_011542982.1  GDP-fucose protein O-fucosyltransferase 3 isoform X5

      UniProtKB/TrEMBL
      B4DLS4
      Conserved Domains (2) summary
      pfam00852
      Location:261 → 396
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:125 → 219
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      33578178..33744498 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361370.1 → XP_054217345.1  GDP-fucose protein O-fucosyltransferase 3 isoform X1

      UniProtKB/TrEMBL
      B4DLS4

    2. XM_054361372.1 → XP_054217347.1  GDP-fucose protein O-fucosyltransferase 3 isoform X3

      UniProtKB/TrEMBL
      B4DLS4

    3. XM_054361371.1 → XP_054217346.1  GDP-fucose protein O-fucosyltransferase 3 isoform X2

      UniProtKB/TrEMBL
      B4DLS4

    4. XM_054361375.1 → XP_054217350.1  GDP-fucose protein O-fucosyltransferase 3 isoform X6

      UniProtKB/TrEMBL
      B4DLS4

    5. XM_054361376.1 → XP_054217351.1  GDP-fucose protein O-fucosyltransferase 3 isoform X7

      UniProtKB/TrEMBL
      B4DLS4

    6. XM_054361373.1 → XP_054217348.1  GDP-fucose protein O-fucosyltransferase 3 isoform X4

      UniProtKB/TrEMBL
      B4DLS4

    7. XM_054361374.1 → XP_054217349.1  GDP-fucose protein O-fucosyltransferase 3 isoform X5

      UniProtKB/TrEMBL
      B4DLS4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P4F1.2 GenPept UniProtKB/Swiss-Prot:Q6P4F1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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