U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    SORBS2 sorbin and SH3 domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 8470, updated on 17-Sep-2022

    Summary

    Official Symbol
    SORBS2provided by HGNC
    Official Full Name
    sorbin and SH3 domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:24098
    See related
    Ensembl:ENSG00000154556 MIM:616349; AllianceGenome:HGNC:24098
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARGBP2; PRO0618
    Summary
    Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in heart (RPKM 46.6), adrenal (RPKM 26.3) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SORBS2 in Genome Data Viewer
    Location:
    4q35.1
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (185585523..185956372, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (188926307..189297353, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (186506677..186877526, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene PDZ and LIM domain 3 Neighboring gene VISTA enhancer hs2502 Neighboring gene Sharpr-MPRA regulatory region 2405 Neighboring gene Sharpr-MPRA regulatory region 123 Neighboring gene uncharacterized LOC101928929 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC124900828 Neighboring gene uncharacterized LOC124900830 Neighboring gene uncharacterized LOC124900829

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr upregulates SORBS2 in HeLa cells within 12 hours of exposure PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ93447, KIAA0777

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in cell growth involved in cardiac muscle cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Z disc NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in actin cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    sorbin and SH3 domain-containing protein 2
    Names
    Arg binding protein 2
    Arg/Abl-interacting protein 2
    arg-binding protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029709.1 RefSeqGene

      Range
      149523..376194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001145670.2NP_001139142.1  sorbin and SH3 domain-containing protein 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) originates from an alternate promoter and has a different 5'UTR and first coding exon compared to variant 1. The resulting protein isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC093797, AC104805, AC108472
      Consensus CDS
      CCDS47173.1
      UniProtKB/Swiss-Prot
      O94875
      Related
      ENSP00000397262.2, ENST00000449407.6
      Conserved Domains (3) summary
      cd11923
      Location:485541
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      pfam02208
      Location:156197
      Sorb; Sorbin homologous domain
      cl17036
      Location:584644
      SH3; Src Homology 3 domain superfamily
    2. NM_001145671.3NP_001139143.1  sorbin and SH3 domain-containing protein 2 isoform 4

      See identical proteins and their annotated locations for NP_001139143.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) originates from an alternate promoter and has a different 5'UTR and first coding exon and includes alternate in-frame exons compared to variant 1. The resulting protein isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC093797, AC104805, AC108472
      Consensus CDS
      CCDS47174.1
      UniProtKB/Swiss-Prot
      O94875
      Related
      ENSP00000322182.9, ENST00000319471.13
      Conserved Domains (3) summary
      smart00459
      Location:153203
      Sorb; Sorbin homologous domain
      cd11923
      Location:572628
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:671731
      SH3; Src Homology 3 domain superfamily
    3. NM_001145672.2NP_001139144.1  sorbin and SH3 domain-containing protein 2 isoform 5

      See identical proteins and their annotated locations for NP_001139144.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) originates from an alternate promoter and has a different 5'UTR and first coding exon and includes alternate in-frame exons compared to variant 1. The resulting protein isoform (5) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC093797, AC104805, AC108472
      Consensus CDS
      CCDS54825.1
      UniProtKB/Swiss-Prot
      O94875
      Related
      ENSP00000401818.2, ENST00000451974.6
      Conserved Domains (4) summary
      cd11923
      Location:502558
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      PHA03132
      Location:219411
      PHA03132; thymidine kinase; Provisional
      pfam02208
      Location:139183
      Sorb; Sorbin homologous domain
      cl17036
      Location:601661
      SH3; Src Homology 3 domain superfamily
    4. NM_001145673.3NP_001139145.1  sorbin and SH3 domain-containing protein 2 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) originates from an alternate promoter and has a different 5'UTR and first coding exon and includes alternate in-frame exons compared to variant 1. The resulting protein isoform (6) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC093797, AC104805, AC108472
      Consensus CDS
      CCDS47175.1
      UniProtKB/Swiss-Prot
      O94875
      Related
      ENSP00000396008.2, ENST00000437304.6
      Conserved Domains (3) summary
      cd11923
      Location:665721
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      pfam02208
      Location:249293
      Sorb; Sorbin homologous domain
      cl17036
      Location:764824
      SH3; Src Homology 3 domain superfamily
    5. NM_001145674.3NP_001139146.1  sorbin and SH3 domain-containing protein 2 isoform 7

      See identical proteins and their annotated locations for NP_001139146.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) originates from an alternate promoter and has a different 5'UTR and first coding exon compared to variant 1. The resulting protein isoform (7) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC093797
      Consensus CDS
      CCDS47176.1
      UniProtKB/Swiss-Prot
      O94875
      Related
      ENSP00000511887.1, ENST00000487836.6
      Conserved Domains (4) summary
      cd11917
      Location:9441004
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:845901
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl02617
      Location:829
      Sorb; Sorbin homologous domain
      cl17036
      Location:770824
      SH3; Src Homology 3 domain superfamily
    6. NM_001145675.3NP_001139147.1  sorbin and SH3 domain-containing protein 2 isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) originates from an alternate promoter and has a different 5' UTR and first coding exon compared to variant 1. The resulting protein isoform (8) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC093797
      UniProtKB/TrEMBL
      B7Z997
      Related
      ENSP00000511889.1, ENST00000490562.6
      Conserved Domains (3) summary
      cd11923
      Location:333389
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl02617
      Location:833
      Sorb; Sorbin homologous domain
      cl17036
      Location:432492
      SH3; Src Homology 3 domain superfamily
    7. NM_001270771.3NP_001257700.1  sorbin and SH3 domain-containing protein 2 isoform 9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) originates from an alternate promoter, has a different 5' UTR, and several in-frame differences in the coding region compared to variant 1, which results in a longer isoform (7) compared to isoform 1.
      Source sequence(s)
      AC093797, AC096659, AC104805, AC108472
      Consensus CDS
      CCDS59482.1
      UniProtKB/Swiss-Prot
      O94875
      Related
      ENSP00000347852.5, ENST00000355634.9
      Conserved Domains (4) summary
      cd11917
      Location:11401200
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:9661020
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:10411097
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      pfam02208
      Location:170214
      Sorb; Sorbin homologous domain
    8. NM_001394245.1NP_001381174.1  sorbin and SH3 domain-containing protein 2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:153203
      Sorb; Sorbin homologous domain
      cd11917
      Location:12261286
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:10521106
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:11271183
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    9. NM_001394246.1NP_001381175.1  sorbin and SH3 domain-containing protein 2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:153203
      Sorb; Sorbin homologous domain
      cd11917
      Location:12071267
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:10331087
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:11081164
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    10. NM_001394247.1NP_001381176.1  sorbin and SH3 domain-containing protein 2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:153203
      Sorb; Sorbin homologous domain
      cd11917
      Location:12071267
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:10331087
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:11081164
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    11. NM_001394248.1NP_001381177.1  sorbin and SH3 domain-containing protein 2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC096659, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:130180
      Sorb; Sorbin homologous domain
      cd11917
      Location:11841244
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:10101064
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:10851141
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    12. NM_001394249.1NP_001381178.1  sorbin and SH3 domain-containing protein 2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:130180
      Sorb; Sorbin homologous domain
      cd11917
      Location:11841244
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:10101064
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:10851141
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    13. NM_001394250.1NP_001381179.1  sorbin and SH3 domain-containing protein 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:153203
      Sorb; Sorbin homologous domain
      cd11917
      Location:11791239
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:10051059
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:10801136
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    14. NM_001394251.1NP_001381180.1  sorbin and SH3 domain-containing protein 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      cd11917
      Location:11401200
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:9661020
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:10411097
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      pfam02208
      Location:170214
      Sorb; Sorbin homologous domain
    15. NM_001394252.1NP_001381181.1  sorbin and SH3 domain-containing protein 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      cd11917
      Location:11401200
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:9661020
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:10411097
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      pfam02208
      Location:170214
      Sorb; Sorbin homologous domain
    16. NM_001394253.1NP_001381182.1  sorbin and SH3 domain-containing protein 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      cd11917
      Location:11401200
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:9661020
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:10411097
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      pfam02208
      Location:170214
      Sorb; Sorbin homologous domain
    17. NM_001394254.1NP_001381183.1  sorbin and SH3 domain-containing protein 2 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Related
      ENSP00000511891.1, ENST00000695410.1
      Conserved Domains (4) summary
      smart00459
      Location:67117
      Sorb; Sorbin homologous domain
      cd11917
      Location:11401200
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:9661020
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:10411097
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    18. NM_001394255.1NP_001381184.1  sorbin and SH3 domain-containing protein 2 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC096659, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:153203
      Sorb; Sorbin homologous domain
      cd11917
      Location:11261186
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:9521006
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:10271083
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    19. NM_001394256.1NP_001381185.1  sorbin and SH3 domain-containing protein 2 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:153203
      Sorb; Sorbin homologous domain
      cd11917
      Location:11261186
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:9521006
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:10271083
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    20. NM_001394257.1NP_001381186.1  sorbin and SH3 domain-containing protein 2 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC096659, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:153203
      Sorb; Sorbin homologous domain
      cd11917
      Location:11261186
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:9521006
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:10271083
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    21. NM_001394258.1NP_001381187.1  sorbin and SH3 domain-containing protein 2 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:67117
      Sorb; Sorbin homologous domain
      cd11917
      Location:11211181
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:9471001
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:10221078
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    22. NM_001394259.1NP_001381188.1  sorbin and SH3 domain-containing protein 2 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:153198
      Sorb; Sorbin homologous domain
      cd11917
      Location:11111171
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:937991
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:10121068
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    23. NM_001394260.1NP_001381189.1  sorbin and SH3 domain-containing protein 2 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:153198
      Sorb; Sorbin homologous domain
      cd11917
      Location:11111171
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:937991
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:10121068
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    24. NM_001394261.1NP_001381190.1  sorbin and SH3 domain-containing protein 2 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:136186
      Sorb; Sorbin homologous domain
      cd11917
      Location:11091169
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:935989
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:10101066
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    25. NM_001394262.1NP_001381191.1  sorbin and SH3 domain-containing protein 2 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC096659, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:130180
      Sorb; Sorbin homologous domain
      cd11917
      Location:11031163
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:929983
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:10041060
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    26. NM_001394263.1NP_001381192.1  sorbin and SH3 domain-containing protein 2 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:130180
      Sorb; Sorbin homologous domain
      cd11917
      Location:11031163
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:929983
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:10041060
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    27. NM_001394264.1NP_001381193.1  sorbin and SH3 domain-containing protein 2 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC096659, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:67112
      Sorb; Sorbin homologous domain
      cd11917
      Location:10781138
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:904958
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:9791035
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    28. NM_001394265.1NP_001381194.1  sorbin and SH3 domain-containing protein 2 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:113158
      Sorb; Sorbin homologous domain
      cd11917
      Location:10711131
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:897951
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:9721028
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    29. NM_001394266.1NP_001381195.1  sorbin and SH3 domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC096659, AC104805, AC108472
      UniProtKB/Swiss-Prot
      Q96EX0
      Conserved Domains (4) summary
      smart00459
      Location:67117
      Sorb; Sorbin homologous domain
      cd11917
      Location:10401100
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:866920
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:941997
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    30. NM_001394267.1NP_001381196.1  sorbin and SH3 domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC096659, AC104805, AC108472
      UniProtKB/Swiss-Prot
      Q96EX0
      Conserved Domains (4) summary
      smart00459
      Location:67117
      Sorb; Sorbin homologous domain
      cd11917
      Location:10401100
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:866920
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:941997
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    31. NM_001394268.1NP_001381197.1  sorbin and SH3 domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC096659, AC104805, AC108472
      UniProtKB/Swiss-Prot
      Q96EX0
      Conserved Domains (4) summary
      smart00459
      Location:67117
      Sorb; Sorbin homologous domain
      cd11917
      Location:10401100
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:866920
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:941997
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    32. NM_001394270.1NP_001381199.1  sorbin and SH3 domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      UniProtKB/Swiss-Prot
      Q96EX0
      Conserved Domains (4) summary
      smart00459
      Location:67117
      Sorb; Sorbin homologous domain
      cd11917
      Location:10401100
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:866920
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:941997
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    33. NM_001394271.1NP_001381200.1  sorbin and SH3 domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      UniProtKB/Swiss-Prot
      Q96EX0
      Conserved Domains (4) summary
      smart00459
      Location:67117
      Sorb; Sorbin homologous domain
      cd11917
      Location:10401100
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:866920
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:941997
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    34. NM_001394272.1NP_001381201.1  sorbin and SH3 domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      UniProtKB/Swiss-Prot
      Q96EX0
      Conserved Domains (4) summary
      smart00459
      Location:67117
      Sorb; Sorbin homologous domain
      cd11917
      Location:10401100
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:866920
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:941997
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    35. NM_001394273.1NP_001381202.1  sorbin and SH3 domain-containing protein 2 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC093797
      Conserved Domains (4) summary
      cd11917
      Location:10311091
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:857911
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:932988
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl02617
      Location:436
      Sorb; Sorbin homologous domain
    36. NM_001394274.1NP_001381203.1  sorbin and SH3 domain-containing protein 2 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:67112
      Sorb; Sorbin homologous domain
      cd11917
      Location:10251085
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:851905
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:926982
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    37. NM_001394275.1NP_001381204.1  sorbin and SH3 domain-containing protein 2 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:67112
      Sorb; Sorbin homologous domain
      cd11917
      Location:10251085
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:851905
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:926982
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    38. NM_001394276.1NP_001381205.1  sorbin and SH3 domain-containing protein 2 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC093797, AC104805, AC108472
      Conserved Domains (4) summary
      smart00459
      Location:485535
      Sorb; Sorbin homologous domain
      cd11917
      Location:10031063
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:829883
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:904960
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    39. NM_001394277.1NP_001381206.1  sorbin and SH3 domain-containing protein 2 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC093797
      Conserved Domains (4) summary
      cd11917
      Location:9591019
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:785839
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:860916
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl02617
      Location:436
      Sorb; Sorbin homologous domain
    40. NM_001395207.1NP_001382136.1  sorbin and SH3 domain-containing protein 2 isoform 26

      Status: REVIEWED

      Description
      Transcript Variant: This variant (42) represents the longest transcript and encodes the longest isoform (26).
      Source sequence(s)
      AC093797, AC104805, AC108472
      Related
      ENSP00000511888.1, ENST00000695409.1
      Conserved Domains (4) summary
      smart00459
      Location:167217
      Sorb; Sorbin homologous domain
      cd11917
      Location:12401300
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:10661120
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:11411197
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
    41. NM_003603.7NP_003594.3  sorbin and SH3 domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_003594.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs at the 5' end, and contains a small in-frame insertion and a large in-frame deletion compared to transcript variant 2. It encodes a shorter isoform (1) with a different amino-terminal, but the same carboxy-terminal sequence containing three SH3 domains, as isoform 2.
      Source sequence(s)
      AC093797, AC104805, AC108472
      Consensus CDS
      CCDS43289.2
      UniProtKB/Swiss-Prot
      O94875
      UniProtKB/TrEMBL
      B7Z3D7
      Related
      ENSP00000377162.3, ENST00000393528.7
      Conserved Domains (3) summary
      smart00459
      Location:113163
      Sorb; Sorbin homologous domain
      cd11923
      Location:507563
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cl17036
      Location:606666
      SH3; Src Homology 3 domain superfamily
    42. NM_021069.6NP_066547.1  sorbin and SH3 domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_066547.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs at the 5' end, and contains a large in-frame insertion and a small in-frame deletion compared to transcript variant 1. It encodes a longer isoform (2) with a different amino-terminal, but the same carboxy-terminal sequence containing three SH3 domains, as isoform 1.
      Source sequence(s)
      AC093797, AC096659, AC104805, AC108472
      Consensus CDS
      CCDS3845.1
      UniProtKB/Swiss-Prot
      O94875, Q96EX0
      Related
      ENSP00000284776.7, ENST00000284776.11
      Conserved Domains (4) summary
      smart00459
      Location:67117
      Sorb; Sorbin homologous domain
      cd11917
      Location:10401100
      SH3_Sorbs2_3; Third (or C-terminal) Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11920
      Location:866920
      SH3_Sorbs2_1; First Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)
      cd11923
      Location:941997
      SH3_Sorbs2_2; Second Src Homology 3 domain of Sorbin and SH3 domain containing 2 (Sorbs2), also called Arg-binding protein 2 (ArgBP2)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      185585523..185956372 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      188926307..189297353 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)