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    PPP1R9B protein phosphatase 1 regulatory subunit 9B [ Homo sapiens (human) ]

    Gene ID: 84687, updated on 10-Dec-2024

    Summary

    Official Symbol
    PPP1R9Bprovided by HGNC
    Official Full Name
    protein phosphatase 1 regulatory subunit 9Bprovided by HGNC
    Primary source
    HGNC:HGNC:9298
    See related
    Ensembl:ENSG00000108819 MIM:603325; AllianceGenome:HGNC:9298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Spn; SPINO; PPP1R6; PPP1R9
    Summary
    This gene encodes a scaffold protein that functions as a regulatory subunit of protein phosphatase 1a. Expression of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in receiving signals from the central nervous system. The encoded protein has putative tumor suppressor function and decreased expression has been observed in tumors. [provided by RefSeq, Feb 2014]
    Expression
    Ubiquitous expression in brain (RPKM 26.2), spleen (RPKM 25.4) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PPP1R9B in Genome Data Viewer
    Location:
    17q21.33
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (50133737..50150677, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (51000814..51017737, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (48211101..48228038, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48178368-48178977 Neighboring gene pyruvate dehydrogenase kinase 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:48184631-48185830 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:48189161-48189846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48189847-48190532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48191458-48192053 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:48193223-48193766 Neighboring gene sterile alpha motif domain containing 14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8680 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8682 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:48209774-48210516 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:48210517-48211258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48223652-48224322 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48224323-48224991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12379 Neighboring gene uncharacterized LOC124904025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8683 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8684 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8685 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8686 Neighboring gene Sharpr-MPRA regulatory region 5931 Neighboring gene CRISPRi-validated cis-regulatory element chr17.3603 Neighboring gene uncharacterized LOC105371818 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8687 Neighboring gene Sharpr-MPRA regulatory region 13843 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48240960-48241460 Neighboring gene sarcoglycan alpha Neighboring gene H1.9 linker histone, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ30345

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables D2 dopamine receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase 1 binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein phosphatase inhibitor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in RNA splicing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in actin filament depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to epidermal growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to morphine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to peptide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dendrite development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in developmental process involved in reproduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hippocampus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in learning IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male mating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of protein localization to actin cortical patch IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to cell periphery IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell growth by extracellular stimulus TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell population proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of exit from mitosis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of opioid receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of postsynapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in reproductive system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to L-phenylalanine derivative IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to immobilization stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to kainic acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to prostaglandin E IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to steroid hormone IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic side of dendritic spine plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendritic spine head IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine neck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extrinsic component of postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of protein phosphatase type 1 complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in ruffle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spine apparatus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    neurabin-2
    Names
    neurabin-II
    protein phosphatase 1, regulatory (inhibitor) subunit 9B
    protein phosphatase 1, regulatory subunit 9B, spinophilin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034197.1 RefSeqGene

      Range
      4841..21781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_032595.5NP_115984.3  neurabin-2

      See identical proteins and their annotated locations for NP_115984.3

      Status: REVIEWED

      Source sequence(s)
      ABBA01041227, AC002401, AJ401189, AL713642, BF448737, BM991997
      Consensus CDS
      CCDS74102.1
      UniProtKB/Swiss-Prot
      D3DTX6, Q8TCR9, Q96SB3
      Related
      ENSP00000478767.1, ENST00000612501.2
      Conserved Domains (3) summary
      smart00228
      Location:493582
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      TIGR02168
      Location:649812
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17817
      Location:426489
      PDZ_5; PDZ domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      50133737..50150677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      51000814..51017737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)