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    INSM2 INSM transcriptional repressor 2 [ Homo sapiens (human) ]

    Gene ID: 84684, updated on 27-Nov-2024

    Summary

    Official Symbol
    INSM2provided by HGNC
    Official Full Name
    INSM transcriptional repressor 2provided by HGNC
    Primary source
    HGNC:HGNC:17539
    See related
    Ensembl:ENSG00000168348 MIM:614027; AllianceGenome:HGNC:17539
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IA6; IA-6; mlt1
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; neuron differentiation; and regulation of cell cycle process. Predicted to be located in cytoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See INSM2 in Genome Data Viewer
    Location:
    14q13.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (35534164..35537054)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (29721890..29724780)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (36003370..36006260)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984681 Neighboring gene uncharacterized LOC105370450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:36002164-36002988 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:36002989-36003812 Neighboring gene keratin 18 pseudogene 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:36003813-36004636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:36004637-36005459 Neighboring gene VISTA enhancer hs348 Neighboring gene Ral GTPase activating protein catalytic subunit alpha 1 Neighboring gene uncharacterized LOC124900348 Neighboring gene small nucleolar RNA, H/ACA box 101B

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell cycle process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription repressor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    insulinoma-associated protein 2
    Names
    insulinoma-associated 2
    insulinoma-associated protein IA-6
    zinc finger protein IA-6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032594.4NP_115983.3  insulinoma-associated protein 2

      See identical proteins and their annotated locations for NP_115983.3

      Status: VALIDATED

      Source sequence(s)
      AF260323, AL160231, BC130377
      Consensus CDS
      CCDS9657.1
      UniProtKB/Swiss-Prot
      A1L432, J9Y024, Q8N8K7, Q96Q84, Q96T92
      Related
      ENSP00000306523.3, ENST00000307169.4
      Conserved Domains (3) summary
      sd00017
      Location:265285
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:426448
      zf-C2H2; Zinc finger, C2H2 type
      cl00873
      Location:140203
      PdxA; Pyridoxal phosphate biosynthetic protein PdxA

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      35534164..35537054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      29721890..29724780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)