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    IL1F10 interleukin 1 family member 10 [ Homo sapiens (human) ]

    Gene ID: 84639, updated on 6-May-2024

    Summary

    Official Symbol
    IL1F10provided by HGNC
    Official Full Name
    interleukin 1 family member 10provided by HGNC
    Primary source
    HGNC:HGNC:15552
    See related
    Ensembl:ENSG00000136697 MIM:615296; AllianceGenome:HGNC:15552
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IL-38; FKSG75; IL1HY2; IL-1HY2; IL1-theta; FIL1-theta
    Summary
    The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward skin (RPKM 1.0) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    2q14.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (113067970..113075843)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (113494498..113502373)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113825547..113833420)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene interleukin 36 beta Neighboring gene Sharpr-MPRA regulatory region 4990 Neighboring gene interleukin 36 receptor antagonist Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:113835447-113836646 Neighboring gene Sharpr-MPRA regulatory region 10370 Neighboring gene RNA, U6 small nuclear 1180, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16411 Neighboring gene interleukin 1 receptor antagonist Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16412

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies protein quantitative trait loci (pQTLs).
    EBI GWAS Catalog
    Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
    EBI GWAS Catalog
    Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
    EBI GWAS Catalog
    Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC119831, MGC119832, MGC119833

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables interleukin-1 receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inflammatory response to antigenic stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    interleukin-1 family member 10
    Names
    FIL1 theta
    IL-1 theta
    IL-1F10 (canonical form IL-1F10a)
    family of interleukin 1-theta
    interleukin 1 family member 10 (theta)
    interleukin-1 HY2
    interleukin-1 receptor antagonist FKSG75
    interleukin-1 receptor antagonist-like FIL1 theta
    interleukin-38

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032556.6NP_115945.4  interleukin-1 family member 10

      See identical proteins and their annotated locations for NP_115945.4

      Status: REVIEWED

      Source sequence(s)
      AC016724, AF334755, AY358846
      Consensus CDS
      CCDS2112.1
      UniProtKB/Swiss-Prot
      Q53SR9, Q56AT8, Q7RTZ5, Q8WWZ1, Q969H5, Q9BYX1
      Related
      ENSP00000376893.2, ENST00000393197.3
      Conserved Domains (1) summary
      cl00094
      Location:10149
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    2. NM_173161.3NP_775184.1  interleukin-1 family member 10

      See identical proteins and their annotated locations for NP_775184.1

      Status: REVIEWED

      Source sequence(s)
      AY029413, AY358846
      Consensus CDS
      CCDS2112.1
      UniProtKB/Swiss-Prot
      Q53SR9, Q56AT8, Q7RTZ5, Q8WWZ1, Q969H5, Q9BYX1
      Related
      ENSP00000341794.2, ENST00000341010.6
      Conserved Domains (1) summary
      cl00094
      Location:10149
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      113067970..113075843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      113494498..113502373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)