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    KLF11 Kruppel like factor 11 [ Homo sapiens (human) ]

    Gene ID: 8462, updated on 19-Jul-2021

    Summary

    Official Symbol
    KLF11provided by HGNC
    Official Full Name
    Kruppel like factor 11provided by HGNC
    Primary source
    HGNC:HGNC:11811
    See related
    Ensembl:ENSG00000172059 MIM:603301
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FKLF; FKLF1; MODY7; TIEG2; Tieg3
    Summary
    The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
    Expression
    Ubiquitous expression in testis (RPKM 20.2), lung (RPKM 12.4) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See KLF11 in Genome Data Viewer
    Location:
    2p25.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (10043550..10054836)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (10183677..10194963)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268412 Neighboring gene uncharacterized LOC101929882 Neighboring gene cystin 1 Neighboring gene ribonucleotide reductase regulatory subunit M2 Neighboring gene microRNA 4261

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    GeneReviews: Not available
    Maturity-onset diabetes of the young type 7 Compare labs

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    Krueppel-like factor 11
    Names
    TGFB-inducible early growth response protein 2
    TIEG-2
    transforming growth factor-beta-inducible early growth response protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017199.1 RefSeqGene

      Range
      5001..16282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001177716.2NP_001171187.1  Krueppel-like factor 11 isoform b

      See identical proteins and their annotated locations for NP_001171187.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC104794
      Consensus CDS
      CCDS54333.1
      UniProtKB/Swiss-Prot
      O14901
      UniProtKB/TrEMBL
      B7ZAX4
      Related
      ENSP00000444690.1, ENST00000540845.5
      Conserved Domains (4) summary
      COG5048
      Location:376432
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382401
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:437459
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:423446
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001177718.2NP_001171189.1  Krueppel-like factor 11 isoform b

      See identical proteins and their annotated locations for NP_001171189.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC104794
      Consensus CDS
      CCDS54333.1
      UniProtKB/Swiss-Prot
      O14901
      Related
      ENSP00000442722.1, ENST00000535335.1
      Conserved Domains (4) summary
      COG5048
      Location:376432
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:382401
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:437459
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:423446
      zf-H2C2_2; Zinc-finger double domain
    3. NM_003597.5NP_003588.1  Krueppel-like factor 11 isoform a

      See identical proteins and their annotated locations for NP_003588.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC104794
      Consensus CDS
      CCDS1668.1
      UniProtKB/Swiss-Prot
      O14901
      UniProtKB/TrEMBL
      Q53QU8
      Related
      ENSP00000307023.1, ENST00000305883.6
      Conserved Domains (4) summary
      COG5048
      Location:393449
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:399418
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:454476
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:440463
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      10043550..10054836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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