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    ELOF1 elongation factor 1 [ Homo sapiens (human) ]

    Gene ID: 84337, updated on 5-Mar-2024

    Summary

    Official Symbol
    ELOF1provided by HGNC
    Official Full Name
    elongation factor 1provided by HGNC
    Primary source
    HGNC:HGNC:28691
    See related
    Ensembl:ENSG00000130165 MIM:619818; AllianceGenome:HGNC:28691
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ELF1
    Summary
    Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in epigenetic maintenance of chromatin in transcription-competent conformation and transcription elongation from RNA polymerase II promoter. Predicted to be located in nucleus. Predicted to be part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 39.1), prostate (RPKM 12.1) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ELOF1 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11553046..11559230, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11680553..11686741, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11663861..11670045, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ECSIT signaling integrator Neighboring gene ribosomal protein S12 pseudogene 32 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10117 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10118 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11648637-11649582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14022 Neighboring gene calponin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11662408-11663379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14024 Neighboring gene Sharpr-MPRA regulatory region 7075 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14025 Neighboring gene uncharacterized LOC124904638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11687946-11688558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11688559-11689170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14027 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11692934-11693099 Neighboring gene acid phosphatase 5, tartrate resistant Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14029 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 76

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    transcription elongation factor 1 homolog
    Names
    ELF1 homolog, elongation factor 1
    elongation factor 1 homolog (ELF1, S. cerevisiae)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363673.3NP_001350602.2  transcription elongation factor 1 homolog

      Status: VALIDATED

      Source sequence(s)
      AC008481
      Consensus CDS
      CCDS12264.1
      UniProtKB/Swiss-Prot
      P60002, Q8R1J7, Q96II4
      UniProtKB/TrEMBL
      K7EPC8
      Related
      ENSP00000465765.2, ENST00000587806.5
      Conserved Domains (1) summary
      pfam05129
      Location:2080
      Elf1; Transcription elongation factor Elf1 like
    2. NM_001363674.4NP_001350603.2  transcription elongation factor 1 homolog

      Status: VALIDATED

      Source sequence(s)
      AC008481, AC009001
      Consensus CDS
      CCDS12264.1
      UniProtKB/Swiss-Prot
      P60002, Q8R1J7, Q96II4
      UniProtKB/TrEMBL
      K7EPC8
      Conserved Domains (1) summary
      pfam05129
      Location:2080
      Elf1; Transcription elongation factor Elf1 like
    3. NM_001363675.4NP_001350604.2  transcription elongation factor 1 homolog

      Status: VALIDATED

      Source sequence(s)
      AC008481, AC009001
      Consensus CDS
      CCDS12264.1
      UniProtKB/Swiss-Prot
      P60002, Q8R1J7, Q96II4
      UniProtKB/TrEMBL
      K7EPC8
      Conserved Domains (1) summary
      pfam05129
      Location:2080
      Elf1; Transcription elongation factor Elf1 like
    4. NM_032377.4NP_115753.1  transcription elongation factor 1 homolog

      See identical proteins and their annotated locations for NP_115753.1

      Status: VALIDATED

      Source sequence(s)
      AC008481, BG718042
      Consensus CDS
      CCDS12264.1
      UniProtKB/Swiss-Prot
      P60002, Q8R1J7, Q96II4
      UniProtKB/TrEMBL
      K7EPC8
      Related
      ENSP00000252445.3, ENST00000252445.8
      Conserved Domains (1) summary
      pfam05129
      Location:2080
      Elf1; Transcription elongation factor Elf1 like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      11553046..11559230 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      11680553..11686741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)