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    GINS4 GINS complex subunit 4 [ Homo sapiens (human) ]

    Gene ID: 84296, updated on 17-Jun-2024

    Summary

    Official Symbol
    GINS4provided by HGNC
    Official Full Name
    GINS complex subunit 4provided by HGNC
    Primary source
    HGNC:HGNC:28226
    See related
    Ensembl:ENSG00000147536 MIM:610611; AllianceGenome:HGNC:28226
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLD5
    Summary
    The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in lymph node (RPKM 2.4), appendix (RPKM 2.0) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See GINS4 in Genome Data Viewer
    Location:
    8p11.21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (41529261..41545030)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (41802893..41818725)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (41386780..41402549)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27284 Neighboring gene golgin A7 Neighboring gene keratin 18 pseudogene 37 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19143 Neighboring gene GPAT4 and GINS4 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27287 Neighboring gene uncharacterized LOC124901939 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:41424977-41425739 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:41430689-41430895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27288 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27289 Neighboring gene glycerol-3-phosphate acyltransferase 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41451733-41452234 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:41454165-41454665 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:41466108-41467307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27290

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of GINS complex subunit 4 (GINS4) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC14799

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CMG complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of CMG complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of GINS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of GINS complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA replication complex GINS protein SLD5
    Names
    SLD5 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032336.3NP_115712.1  DNA replication complex GINS protein SLD5

      See identical proteins and their annotated locations for NP_115712.1

      Status: VALIDATED

      Source sequence(s)
      AC009630, BC005995
      Consensus CDS
      CCDS6116.1
      UniProtKB/Swiss-Prot
      B2R8H5, D3DSY0, Q8N648, Q9BRT9
      UniProtKB/TrEMBL
      E5RFF9
      Related
      ENSP00000276533.3, ENST00000276533.4
      Conserved Domains (2) summary
      cd11711
      Location:26146
      GINS_A_Sld5; Alpha-helical domain of GINS complex protein Sld5
      cd21692
      Location:165223
      GINS_B_Sld5; beta-strand (B) domain of GINS complex protein Sld5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      41529261..41545030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005273659.5XP_005273716.1  DNA replication complex GINS protein SLD5 isoform X1

      See identical proteins and their annotated locations for XP_005273716.1

      UniProtKB/Swiss-Prot
      B2R8H5, D3DSY0, Q8N648, Q9BRT9
      UniProtKB/TrEMBL
      E5RFF9
      Related
      ENSP00000428754.1, ENST00000518671.5
      Conserved Domains (2) summary
      cd11711
      Location:26146
      GINS_A_Sld5; Alpha-helical domain of GINS complex protein Sld5
      cd21692
      Location:165223
      GINS_B_Sld5; beta-strand (B) domain of GINS complex protein Sld5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      41802893..41818725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361352.1XP_054217327.1  DNA replication complex GINS protein SLD5 isoform X1

      UniProtKB/Swiss-Prot
      B2R8H5, D3DSY0, Q8N648, Q9BRT9
      UniProtKB/TrEMBL
      E5RFF9