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    ATP13A4 ATPase 13A4 [ Homo sapiens (human) ]

    Gene ID: 84239, updated on 5-Jan-2023

    Summary

    Official Symbol
    ATP13A4provided by HGNC
    Official Full Name
    ATPase 13A4provided by HGNC
    Primary source
    HGNC:HGNC:25422
    See related
    Ensembl:ENSG00000127249 MIM:609556; AllianceGenome:HGNC:25422
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable ATPase-coupled cation transmembrane transporter activity. Predicted to be involved in cellular calcium ion homeostasis. Predicted to be located in endoplasmic reticulum membrane and endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in thyroid (RPKM 10.9), lung (RPKM 10.1) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ATP13A4 in Genome Data Viewer
    Location:
    3q29
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (193398967..193593119, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (196094346..196250214, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (193116756..193272684, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized protein MGC2889 Neighboring gene phospholipase A and acyltransferase 1 Neighboring gene ATPase 13A5 Neighboring gene ATP13A5 antisense RNA 1 Neighboring gene ATP13A4 antisense RNA 1 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 23 Neighboring gene OPA1 mitochondrial dynamin like GTPase Neighboring gene OPA1 antisense RNA 1 Neighboring gene uncharacterized LOC102724808

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC126545, DKFZp761I1011

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATPase-coupled monoatomic cation transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    enables P-type transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables polyamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoatomic ion transmembrane transport TAS
    Traceable Author Statement
    more info
     
    involved_in polyamine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in early endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in late endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in recycling endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    probable cation-transporting ATPase 13A4
    Names
    ATPase type 13A4
    P5-ATPase
    cation-transporting P5-ATPase
    NP_115655.2
    XP_016862808.2
    XP_047305019.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032279.4NP_115655.2  probable cation-transporting ATPase 13A4

      See identical proteins and their annotated locations for NP_115655.2

      Status: VALIDATED

      Source sequence(s)
      AC105057, AK096510, AY358110, AY823162, BC101496, DA117883
      Consensus CDS
      CCDS3304.2
      UniProtKB/Swiss-Prot
      Q4VNC1, Q9H043
      UniProtKB/TrEMBL
      B3KU47
      Related
      ENSP00000339182.4, ENST00000342695.9
      Conserved Domains (6) summary
      COG4087
      Location:820869
      COG4087; Soluble P-type ATPase [General function prediction only]
      TIGR01657
      Location:171114
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
      pfam00122
      Location:268471
      E1-E2_ATPase; E1-E2 ATPase
      pfam00690
      Location:157217
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12409
      Location:16136
      P5-ATPase; P5-type ATPase cation transporter
      pfam13246
      Location:595634
      Cation_ATPase; Cation transport ATPase (P-type)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      193398967..193593119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449063.1XP_047305019.1  probable cation-transporting ATPase 13A4 isoform X1

    2. XM_017007319.2XP_016862808.2  probable cation-transporting ATPase 13A4 isoform X2

    RNA

    1. XR_007095757.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      196094346..196250214 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)