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    LOXL4 lysyl oxidase like 4 [ Homo sapiens (human) ]

    Gene ID: 84171, updated on 5-Mar-2024

    Summary

    Official Symbol
    LOXL4provided by HGNC
    Official Full Name
    lysyl oxidase like 4provided by HGNC
    Primary source
    HGNC:HGNC:17171
    See related
    Ensembl:ENSG00000138131 MIM:607318; AllianceGenome:HGNC:17171
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LOXC
    Summary
    This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in thyroid (RPKM 4.0), testis (RPKM 3.7) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    10q24.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (98247690..98268194, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (99128069..99148240, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (100007447..100027951, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:99635581-99636081 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:99641761-99642960 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99647957-99648570 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99648571-99649183 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99649184-99649796 Neighboring gene cartilage acidic protein 1 Neighboring gene microRNA 3085 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:99674250-99674826 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:99712853-99713551 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:99734318-99734920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:99734921-99735522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3860 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:99885542-99886741 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99894841-99895630 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99911422-99912174 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:99912926-99913677 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99913678-99914428 Neighboring gene R3H domain and coiled-coil containing 1 like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3863 Neighboring gene NANOG hESC enhancer GRCh37_chr10:99933024-99933525 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99983165-99983698 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99983699-99984230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:100021241-100022130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:100026897-100027398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:100027399-100027898 Neighboring gene uncharacterized LOC124902489 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:100081209-100081774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3864 Neighboring gene NANOG hESC enhancer GRCh37_chr10:100113671-100114175 Neighboring gene Sharpr-MPRA regulatory region 15191 Neighboring gene uncharacterized LOC105378449 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:100127757-100128375

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ21889

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-lysine 6-oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-lysine 6-oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in collagen fibril organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptidyl-lysine oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    lysyl oxidase homolog 4
    Names
    lysyl oxidase related C
    lysyl oxidase-like 4 pseudogene
    lysyl oxidase-like protein 4
    lysyl oxidase-related protein C
    NP_115587.6
    XP_005270273.1
    XP_006718083.1
    XP_024304000.1
    XP_047281791.1
    XP_047281792.1
    XP_054222884.1
    XP_054222885.1
    XP_054222886.1
    XP_054222887.1
    XP_054222888.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032211.7NP_115587.6  lysyl oxidase homolog 4 precursor

      See identical proteins and their annotated locations for NP_115587.6

      Status: REVIEWED

      Source sequence(s)
      AK172781, BC013153, W44920
      Consensus CDS
      CCDS7473.1
      UniProtKB/Swiss-Prot
      Q5W0B3, Q96DY1, Q96JB6, Q96PC0, Q9H6T5
      Related
      ENSP00000260702.3, ENST00000260702.4
      Conserved Domains (3) summary
      smart00202
      Location:32132
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:41132
      SRCR; Scavenger receptor cysteine-rich domain
      pfam01186
      Location:533728
      Lysyl_oxidase; Lysyl oxidase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      98247690..98268194 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005270216.3XP_005270273.1  lysyl oxidase homolog 4 isoform X1

      See identical proteins and their annotated locations for XP_005270273.1

      Conserved Domains (2) summary
      smart00202
      Location:32132
      SR; Scavenger receptor Cys-rich
      pfam01186
      Location:534733
      Lysyl_oxidase; Lysyl oxidase
    2. XM_047425835.1XP_047281791.1  lysyl oxidase homolog 4 isoform X2

      UniProtKB/Swiss-Prot
      Q5W0B3, Q96DY1, Q96JB6, Q96PC0, Q9H6T5
    3. XM_006718020.2XP_006718083.1  lysyl oxidase homolog 4 isoform X1

      See identical proteins and their annotated locations for XP_006718083.1

      Conserved Domains (2) summary
      smart00202
      Location:32132
      SR; Scavenger receptor Cys-rich
      pfam01186
      Location:534733
      Lysyl_oxidase; Lysyl oxidase
    4. XM_047425836.1XP_047281792.1  lysyl oxidase homolog 4 isoform X2

      UniProtKB/Swiss-Prot
      Q5W0B3, Q96DY1, Q96JB6, Q96PC0, Q9H6T5
    5. XM_024448232.1XP_024304000.1  lysyl oxidase homolog 4 isoform X1

      Conserved Domains (2) summary
      smart00202
      Location:32132
      SR; Scavenger receptor Cys-rich
      pfam01186
      Location:534733
      Lysyl_oxidase; Lysyl oxidase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      99128069..99148240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366909.1XP_054222884.1  lysyl oxidase homolog 4 isoform X1

    2. XM_054366912.1XP_054222887.1  lysyl oxidase homolog 4 isoform X2

      UniProtKB/Swiss-Prot
      Q5W0B3, Q96DY1, Q96JB6, Q96PC0, Q9H6T5
    3. XM_054366910.1XP_054222885.1  lysyl oxidase homolog 4 isoform X1

    4. XM_054366913.1XP_054222888.1  lysyl oxidase homolog 4 isoform X2

      UniProtKB/Swiss-Prot
      Q5W0B3, Q96DY1, Q96JB6, Q96PC0, Q9H6T5
    5. XM_054366911.1XP_054222886.1  lysyl oxidase homolog 4 isoform X1