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    CASP8 caspase 8 [ Homo sapiens (human) ]

    Gene ID: 841, updated on 26-Jul-2021

    Summary

    Official Symbol
    CASP8provided by HGNC
    Official Full Name
    caspase 8provided by HGNC
    Primary source
    HGNC:HGNC:1509
    See related
    Ensembl:ENSG00000064012 MIM:601763
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8
    Summary
    This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in bone marrow (RPKM 26.3), lymph node (RPKM 15.2) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CASP8 in Genome Data Viewer
    Location:
    2q33.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (201233443..201287711)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (202098166..202152434)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene caspase 10 Neighboring gene MT-ND4L pseudogene 13 Neighboring gene MT-ND5 pseudogene 25 Neighboring gene MT-ND4 pseudogene 23 Neighboring gene flagellum associated containing coiled-coil domains 1 Neighboring gene trafficking kinesin protein 2 Neighboring gene SCYL2 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Autoimmune lymphoproliferative syndrome type 2B
    MedGen: C1846545 OMIM: 607271 GeneReviews: Not available
    Compare labs
    Familial cancer of breast Compare labs
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    GeneReviews: Not available
    Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
    GeneReviews: Not available
    Genome-wide association study identifies three new melanoma susceptibility loci.
    GeneReviews: Not available
    Hepatocellular carcinoma
    MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
    Compare labs
    Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
    GeneReviews: Not available
    Lung cancer
    MedGen: C0242379 OMIM: 211980 GeneReviews: Not available
    Compare labs

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show downregulation of caspase 8 (CASP8, apoptosis-related cysteine peptidase) expression as compared to untreated control PubMed
    env Treatment of HIV-1 Env-pseudotyped virus-infected MDM cells with both soluble TRAIL and an agonistic anti-DR5 antibody AD5-10 induces activation of caspase-3, -8, and -9 PubMed
    env HIV-1 gp120-induced neuron apoptosis requires the upregulation of the death receptor Fas and its associated death proteins, FADD and CASP8 PubMed
    env Caspase 8 proteolytic target protein Bid is cleaved and undergoes mitochondrial translocation in gp120-treated p53 expression neurons PubMed
    env HIV-1 gp120-mediated activation of caspase 8 occurs in a p53 independent manner, while HIV-1 gp120-mediated activation of caspase 3 requires p53 PubMed
    env Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9 PubMed
    Envelope transmembrane glycoprotein gp41 env Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9 PubMed
    Nef nef Stable expression of HIV-1 Nef in Jurkat T cells confers resistance to Fas-mediated apoptosis through inactivation of caspase-3 and caspase-8 PubMed
    Tat tat FasL-induced activation of caspase-3 and -8 proteins is inhibited in HIV-1 Tat101-expressing Jurkat cells PubMed
    tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides upregulate gene expression of caspase 8, apoptosis-related cysteine protease (CASP8) in U-937 macrophages PubMed
    tat HIV-1 Tat induces apoptosis and increases sensitivity to apoptotic signals by upregulating FLICE/Caspase-8 PubMed
    Vpr vpr HIV-1 Vpr-mediated apoptosis and mitochondrial depolarization are dependent on CASP8 (caspase 8) activation in THP-1 and monocytes PubMed
    vpr HIV-1 Vpr-induced caspase-8 activation causes cleavage of BID to tBID through ERK activation PubMed
    vpr HIV-1 Vpr induces apoptosis through caspase activation and caspase 8 has been specifically demonstrated in one study to be activated during this process, however in other studies it was not activated PubMed
    Vpu vpu Caspase-8 and caspase-3 activity are required for HIV-1 Vpu-induced cleavage of IRF3 and HIV-1 infection also induces caspase-mediated IRF3 cleavage PubMed
    retropepsin gag-pol HIV-1 Protease cleaves procaspase 8 between amino acids 355 and 356 and generates casp8p41 protein in cells. Casp8p41 is produced in HIV-1-infected cells and colocalizes with dying cells PubMed
    gag-pol HIV-1 protease directly cleaves and activates procaspase 8 in T cells, which is associated with cleavage of BID, mitochondrial release of cytochrome c, activation of the downstream caspases 9 and 3, and cleavage of DFF and PARP PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ17672, MGC78473

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
     
    enables cysteine-type endopeptidase activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cysteine-type peptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables death effector domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables death effector domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables death receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in T cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in TRAIL-activated apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in activation of cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in execution phase of apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in execution phase of apoptosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway via death domain receptors IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in macrophage differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in macrophage differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in natural killer cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of necroptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of necroptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-1 beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of macrophage differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron death IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteolysis involved in cellular protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteolysis involved in cellular protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in pyroptosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of tumor necrosis factor-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cobalt ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cold IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to tumor necrosis factor IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in self proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in syncytiotrophoblast cell differentiation involved in labyrinthine layer development TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CD95 death-inducing signaling complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell body IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of death-inducing signaling complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ripoptosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    caspase-8
    Names
    FADD-homologous ICE/CED-3-like protease
    FADD-like ICE
    ICE-like apoptotic protease 5
    MACH-alpha-1/2/3 protein
    MACH-beta-1/2/3/4 protein
    MORT1-associated ced-3 homolog
    apoptotic cysteine protease
    apoptotic protease Mch-5
    caspase 8, apoptosis-related cysteine peptidase
    caspase 8, apoptosis-related cysteine protease
    NP_001073593.1
    NP_001073594.1
    NP_001219.2
    NP_001358980.1
    NP_203519.1
    NP_203520.1
    NP_203522.1
    XP_005246942.1
    XP_005246944.1
    XP_005246945.1
    XP_005246946.1
    XP_005246947.1
    XP_005246948.1
    XP_005246949.1
    XP_005246950.1
    XP_005246951.1
    XP_005246952.1
    XP_006712852.1
    XP_006712853.1
    XP_006712856.1
    XP_011510271.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007497.1 RefSeqGene

      Range
      4986..59254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_34

    mRNA and Protein(s)

    1. NM_001080124.2NP_001073593.1  caspase-8 isoform C precursor

      See identical proteins and their annotated locations for NP_001073593.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (F) includes different segments in the 5' UTR and lacks an alternate in-frame segment in the coding region, compared to variant G. Variants C and F both encode isoform C, which is shorter than isoform G. Isoform C has also been labelled as Alpha-2 or MCH5-beta.
      Source sequence(s)
      AC007256, AF422927, AI351872
      Consensus CDS
      CCDS2343.1
      UniProtKB/Swiss-Prot
      Q14790
      UniProtKB/TrEMBL
      A0A024R3Z8
      Related
      ENSP00000376091.2, ENST00000392263.6
      Conserved Domains (3) summary
      cd00032
      Location:210462
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:384
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98180
      DD; Death Domain Superfamily of protein-protein interaction domains
    2. NM_001080125.2NP_001073594.1  caspase-8 isoform G precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (G), also known as procaspase-8L or 8L, encodes the longest protein (isoform G).
      Source sequence(s)
      AC007256, AF422927, AI351872, X98172
      Consensus CDS
      CCDS42798.1
      UniProtKB/Swiss-Prot
      Q14790
      Related
      ENSP00000351273.4, ENST00000358485.8
      Conserved Domains (3) summary
      cd00032
      Location:284536
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:62143
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:157239
      DD; Death Domain Superfamily of protein-protein interaction domains
    3. NM_001228.4NP_001219.2  caspase-8 isoform A precursor

      See identical proteins and their annotated locations for NP_001219.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A), also known as Alpha-4, has multiple differences in the 5' UTR and coding region, compared to variant G. It encodes isoform A which is shorter than isoform G.
      Source sequence(s)
      AC007256, AI351872, BC028223, DA420056, U60520
      Consensus CDS
      CCDS42799.1
      UniProtKB/Swiss-Prot
      Q14790
      Related
      ENSP00000264275.5, ENST00000264275.9
      Conserved Domains (3) summary
      cd00032
      Location:242494
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:384
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:134212
      DD; Death Domain Superfamily of protein-protein interaction domains
    4. NM_001372051.1NP_001358980.1  caspase-8 isoform B

      Status: REVIEWED

      Source sequence(s)
      AC007256
      Related
      ENSP00000501268.1, ENST00000673742.1
      Conserved Domains (3) summary
      cd00032
      Location:225477
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:384
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98180
      DD; Death Domain Superfamily of protein-protein interaction domains
    5. NM_033355.3NP_203519.1  caspase-8 isoform B precursor

      See identical proteins and their annotated locations for NP_203519.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (B) includes different segments in its 5' UTR and lacks a 5' coding region segment, compared to variant G. This results in translation at a downstream start codon, and the encoded protein (isoform B) has a shorter N-terminus when it is compared to isoform G.
      Source sequence(s)
      AC007256, AF422928, AI351872, DA420056
      Consensus CDS
      CCDS2342.1
      UniProtKB/Swiss-Prot
      Q14790
      Related
      ENSP00000412523.2, ENST00000432109.6
      Conserved Domains (3) summary
      cd00032
      Location:225477
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:384
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98180
      DD; Death Domain Superfamily of protein-protein interaction domains
    6. NM_033356.4NP_203520.1  caspase-8 isoform C precursor

      See identical proteins and their annotated locations for NP_203520.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (C) includes a different segment in the 5' UTR and lacks an alternate in-frame segment in the coding region, compared to variant G. Variants C and F both encode isoform C, which is shorter than isoform G. Isoform C has also been labelled as Alpha-2 or MCH5-beta.
      Source sequence(s)
      AC007256, AI351872, AL601594, BC028223, X98173
      Consensus CDS
      CCDS2343.1
      UniProtKB/Swiss-Prot
      Q14790
      UniProtKB/TrEMBL
      A0A024R3Z8
      Related
      ENSP00000325722.7, ENST00000323492.11
      Conserved Domains (3) summary
      cd00032
      Location:210462
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:384
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98180
      DD; Death Domain Superfamily of protein-protein interaction domains
    7. NM_033358.4NP_203522.1  caspase-8 isoform E

      See identical proteins and their annotated locations for NP_203522.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (E), also known as Beta-1, has multiple differences, one of which causes a frameshift, compared to variant G. It encodes isoform E, which is shorter than isoform G.
      Source sequence(s)
      AC007256, DA420056, DB157537, X98176
      Consensus CDS
      CCDS2345.1
      UniProtKB/Swiss-Prot
      Q14790
      Related
      ENSP00000376087.3, ENST00000392258.7
      Conserved Domains (2) summary
      cd08333
      Location:384
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98180
      DD; Death Domain Superfamily of protein-protein interaction domains

    RNA

    1. NR_111983.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (H) has an alternate splice site in the central region, compared to variant G. This variant is represented as non-coding because use of the 5'-most expected translation start codon, as used in variant G, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC007256, AF380342, BG236020, U60520

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      201233443..201287711
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006712789.2XP_006712852.1  caspase-8 isoform X2

      See identical proteins and their annotated locations for XP_006712852.1

      UniProtKB/Swiss-Prot
      Q14790
      Conserved Domains (3) summary
      cd00032
      Location:225477
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:384
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98180
      DD; Death Domain Superfamily of protein-protein interaction domains
    2. XM_005246887.2XP_005246944.1  caspase-8 isoform X2

      See identical proteins and their annotated locations for XP_005246944.1

      UniProtKB/Swiss-Prot
      Q14790
      Conserved Domains (3) summary
      cd00032
      Location:225477
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:384
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98180
      DD; Death Domain Superfamily of protein-protein interaction domains
    3. XM_006712793.3XP_006712856.1  caspase-8 isoform X8

      See identical proteins and their annotated locations for XP_006712856.1

      UniProtKB/Swiss-Prot
      Q14790
      Related
      ENSP00000397528.1, ENST00000413726.5
      Conserved Domains (2) summary
      cd08333
      Location:384
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98180
      DD; Death Domain Superfamily of protein-protein interaction domains
    4. XM_005246888.2XP_005246945.1  caspase-8 isoform X2

      See identical proteins and their annotated locations for XP_005246945.1

      UniProtKB/Swiss-Prot
      Q14790
      Conserved Domains (3) summary
      cd00032
      Location:225477
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:384
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98180
      DD; Death Domain Superfamily of protein-protein interaction domains
    5. XM_005246894.4XP_005246951.1  caspase-8 isoform X6

      Conserved Domains (1) summary
      cd00032
      Location:26278
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    6. XM_005246891.5XP_005246948.1  caspase-8 isoform X2

      See identical proteins and their annotated locations for XP_005246948.1

      UniProtKB/Swiss-Prot
      Q14790
      Conserved Domains (3) summary
      cd00032
      Location:225477
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:384
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98180
      DD; Death Domain Superfamily of protein-protein interaction domains
    7. XM_006712790.4XP_006712853.1  caspase-8 isoform X2

      See identical proteins and their annotated locations for XP_006712853.1

      UniProtKB/Swiss-Prot
      Q14790
      Conserved Domains (3) summary
      cd00032
      Location:225477
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:384
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98180
      DD; Death Domain Superfamily of protein-protein interaction domains
    8. XM_005246889.2XP_005246946.1  caspase-8 isoform X2

      See identical proteins and their annotated locations for XP_005246946.1

      UniProtKB/Swiss-Prot
      Q14790
      Conserved Domains (3) summary
      cd00032
      Location:225477
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:384
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98180
      DD; Death Domain Superfamily of protein-protein interaction domains
    9. XM_005246892.2XP_005246949.1  caspase-8 isoform X3

      See identical proteins and their annotated locations for XP_005246949.1

      UniProtKB/Swiss-Prot
      Q14790
      UniProtKB/TrEMBL
      A0A024R3Z8
      Conserved Domains (3) summary
      cd00032
      Location:210462
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:384
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98180
      DD; Death Domain Superfamily of protein-protein interaction domains
    10. XM_005246885.2XP_005246942.1  caspase-8 isoform X1

      Conserved Domains (3) summary
      cd00032
      Location:269521
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:62143
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:157239
      DD; Death Domain Superfamily of protein-protein interaction domains
    11. XM_005246893.3XP_005246950.1  caspase-8 isoform X5

      See identical proteins and their annotated locations for XP_005246950.1

      Conserved Domains (2) summary
      cd08333
      Location:62143
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:157239
      DD; Death Domain Superfamily of protein-protein interaction domains
    12. XM_005246895.3XP_005246952.1  caspase-8 isoform X7

      Conserved Domains (2) summary
      cd08333
      Location:62143
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:157239
      DD; Death Domain Superfamily of protein-protein interaction domains
    13. XM_005246890.4XP_005246947.1  caspase-8 isoform X2

      See identical proteins and their annotated locations for XP_005246947.1

      UniProtKB/Swiss-Prot
      Q14790
      Conserved Domains (3) summary
      cd00032
      Location:225477
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08333
      Location:384
      DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
      cl14633
      Location:98180
      DD; Death Domain Superfamily of protein-protein interaction domains
    14. XM_011511969.2XP_011510271.1  caspase-8 isoform X4

      Conserved Domains (2) summary
      cd00032
      Location:80332
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cl14633
      Location:135
      DD; Death Domain Superfamily of protein-protein interaction domains

    RNA

    1. XR_001738971.1 RNA Sequence

    2. XR_923035.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_033357.2: Suppressed sequence

      Description
      NM_033357.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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