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    MAGT1 magnesium transporter 1 [ Homo sapiens (human) ]

    Gene ID: 84061, updated on 23-Nov-2023

    Summary

    Official Symbol
    MAGT1provided by HGNC
    Official Full Name
    magnesium transporter 1provided by HGNC
    Primary source
    HGNC:HGNC:28880
    See related
    Ensembl:ENSG00000102158 MIM:300715; AllianceGenome:HGNC:28880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IAP; XMEN; MRX95; OST3B; CDG1CC; PRO0756; SLC58A1; bA217H1.1
    Summary
    This gene encodes a ubiquitously expressed magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this gene cause a form of X-linked intellectual disability (XLID). This gene may have multiple in-frame translation initiation sites, one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29. [provided by RefSeq, Jul 2017]
    Expression
    Ubiquitous expression in thyroid (RPKM 54.7), kidney (RPKM 22.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MAGT1 in Genome Data Viewer
    Location:
    Xq21.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (77825747..77895568, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (76263304..76330626, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (77081244..77151065, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:76703913-76704414 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:76749658-76750240 Neighboring gene NANOG hESC enhancer GRCh37_chrX:76757869-76758370 Neighboring gene fibroblast growth factor 16 Neighboring gene ATRX chromatin remodeler Neighboring gene fatty acid binding protein 5 pseudogene 15 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29779 Neighboring gene RNA, U6 small nuclear 854, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29781 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29782 Neighboring gene RNA, 7SL, cytoplasmic 460, pseudogene Neighboring gene cytochrome c oxidase subunit 7B Neighboring gene ATPase copper transporting alpha Neighboring gene C4orf46 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with magnesium transporter 1 (MAGT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ14726, MGC64926, DKFZp564K142

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in azurophil granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in membrane HDA PubMed 
    part_of oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of oligosaccharyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of oligosaccharyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    magnesium transporter protein 1
    Names
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1
    implantation-associated protein
    oligosaccharyl transferase subunit MAGT1
    oligosaccharyltransferase 3 homolog B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016390.1 RefSeqGene

      Range
      5001..74205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_353

    mRNA and Protein(s)

    1. NM_001367916.1NP_001354845.1  magnesium transporter protein 1 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL138743, BC041014, BC060842, DC329979
      Consensus CDS
      CCDS94636.1
      UniProtKB/Swiss-Prot
      B2RAR4, D3DTE3, Q53G00, Q6P577, Q8NBN6, Q9H0U3
      UniProtKB/TrEMBL
      A0A8I5KYH1
      Related
      ENSP00000480732.1, ENST00000618282.5
      Conserved Domains (1) summary
      pfam04756
      Location:42330
      OST3_OST6; OST3 / OST6 family, transporter family
    2. NM_032121.5NP_115497.4  magnesium transporter protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      BC041014, BC060842, DC329979
      Consensus CDS
      CCDS14436.2
      UniProtKB/TrEMBL
      A0A087WU53, B4DH58
      Related
      ENSP00000354649.6, ENST00000358075.11
      Conserved Domains (2) summary
      cd02947
      Location:93203
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
      pfam04756
      Location:199348
      OST3_OST6; OST3 / OST6 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      77825747..77895568 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      76263304..76330626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)