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    Kremen1 kringle containing transmembrane protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 84035, updated on 22-Aug-2021

    Summary

    Official Symbol
    Kremen1provided by MGI
    Official Full Name
    kringle containing transmembrane protein 1provided by MGI
    Primary source
    MGI:MGI:1933988
    See related
    Ensembl:ENSMUSG00000020393
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Krm; Krm1; Kremen; AV002070
    Expression
    Broad expression in thymus adult (RPKM 53.1), heart adult (RPKM 22.2) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Kremen1 in Genome Data Viewer
    Location:
    11; 11 A1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (5141551..5212220, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (5191551..5261713, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (5091555..5161613, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene EMI domain containing 1 Neighboring gene predicted gene, 39572 Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene predicted gene, 25142 Neighboring gene predicted gene, 46268 Neighboring gene predicted gene, 30172 Neighboring gene zinc and ring finger 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in limb development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    kremen protein 1
    Names
    dickkopf receptor
    kringle domain-containing transmembrane protein 1
    kringle-coding gene marking the eye and the nose
    kringle-containing protein marking the eye and the nose
    NP_115772.2
    XP_006514975.1
    XP_006514976.1
    XP_036013001.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032396.3NP_115772.2  kremen protein 1 precursor

      See identical proteins and their annotated locations for NP_115772.2

      Status: VALIDATED

      Source sequence(s)
      BC049771, BC082546
      Consensus CDS
      CCDS24399.1
      UniProtKB/Swiss-Prot
      Q99N43
      Related
      ENSMUSP00000020662.9, ENSMUST00000020662.15
      Conserved Domains (3) summary
      cd00041
      Location:214320
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00108
      Location:31114
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      pfam01822
      Location:119200
      WSC; WSC domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      5141551..5212220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157108.1XP_036013001.1  kremen protein 1 isoform X2

      Conserved Domains (2) summary
      cd00041
      Location:99205
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam01822
      Location:585
      WSC; WSC domain
    2. XM_006514912.4XP_006514975.1  kremen protein 1 isoform X1

      Conserved Domains (3) summary
      cd00041
      Location:214320
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00108
      Location:31114
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      pfam01822
      Location:119200
      WSC; WSC domain
    3. XM_006514913.4XP_006514976.1  kremen protein 1 isoform X3

      Conserved Domains (2) summary
      cd00108
      Location:31114
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      pfam01822
      Location:119200
      WSC; WSC domain
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