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    Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 [ Mus musculus (house mouse) ]

    Gene ID: 83945, updated on 2-Oct-2018

    Summary

    Official Symbol
    Dnaja3provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member A3provided by MGI
    Primary source
    MGI:MGI:1933786
    See related
    Ensembl:ENSMUSG00000004069 Vega:OTTMUSG00000024742
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tid-1; Tid1l; C81173; 1200003J13Rik; 1810053A11Rik
    Expression
    Ubiquitous expression in heart adult (RPKM 29.3), kidney adult (RPKM 24.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dnaja3 in Genome Data Viewer
    Location:
    16 A1; 16 2.46 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (4684070..4707695)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (4684070..4707695)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene GLIS family zinc finger 2 Neighboring gene presequence translocase-asssociated motor 16 homolog (S. cerevisiae) Neighboring gene coronin 7 Neighboring gene vasorin Neighboring gene NmrA-like family domain containing 1 Neighboring gene heme oxygenase 2 Neighboring gene cell death inducing Trp53 target 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    IkappaB kinase complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    interferon-gamma receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    unfolded protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    activation-induced cell death of T cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell aging IDA
    Inferred from Direct Assay
    more info
    PubMed 
    embryo development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interferon-gamma-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuromuscular junction development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    response to heat IEA
    Inferred from Electronic Annotation
    more info
     
    response to interferon-gamma ISO
    Inferred from Sequence Orthology
    more info
     
    skeletal muscle acetylcholine-gated channel clustering IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    small GTPase mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dnaJ homolog subfamily A member 3, mitochondrial
    Names
    DnaJ (Hsp40) homolog, subfamily A, member 3
    dnaJ protein Tid-1
    mTid-1
    tumorous imaginal discs protein Tid56 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135112.1NP_001128584.1  dnaJ homolog subfamily A member 3, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001128584.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' region, as compared to variant 1. The resulting isoform (2) has a shorter and different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK167511, BP757709, CJ148764
      Consensus CDS
      CCDS49748.1
      UniProtKB/Swiss-Prot
      Q99M87
      UniProtKB/TrEMBL
      Q3TJA9
      Related
      ENSMUSP00000111520.3, OTTMUSP00000029082, ENSMUST00000115854.3, OTTMUST00000059742
      Conserved Domains (4) summary
      cd10719
      Location:236296
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:207416
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:90435
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:93155
      DnaJ; DnaJ domain
    2. NM_023646.4NP_076135.3  dnaJ homolog subfamily A member 3, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_076135.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK004910, AK011535, BP757709, CJ148764
      Consensus CDS
      CCDS27922.1
      UniProtKB/Swiss-Prot
      Q99M87
      Related
      ENSMUSP00000053842.5, OTTMUSP00000029081, ENSMUST00000060067.11, OTTMUST00000059741
      Conserved Domains (4) summary
      cd10719
      Location:236296
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:207416
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:90480
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:93155
      DnaJ; DnaJ domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      4684070..4707695
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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