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    HDAC10 histone deacetylase 10 [ Homo sapiens (human) ]

    Gene ID: 83933, updated on 11-Apr-2024

    Summary

    Official Symbol
    HDAC10provided by HGNC
    Official Full Name
    histone deacetylase 10provided by HGNC
    Primary source
    HGNC:HGNC:18128
    See related
    Ensembl:ENSG00000100429 MIM:608544; AllianceGenome:HGNC:18128
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HD10
    Summary
    The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in spleen (RPKM 10.7), bone marrow (RPKM 7.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    22q13.33
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (50245183..50251265, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (50752185..50758268, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50683612..50689694, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50644205-50644771 Neighboring gene selenoprotein O Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50644772-50645337 Neighboring gene SELENOO antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50645905-50646469 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50658024-50658666 Neighboring gene tubulin gamma complex component 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50676935-50677436 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50677437-50677936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19307 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50682041-50682971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19309 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50685959-50686881 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50688039-50688885 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13959 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19311 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50697131-50697703 Neighboring gene mitogen-activated protein kinase 12 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50698428-50698928 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13960 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50700498-50701229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13964 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13965 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13966 Neighboring gene mitogen-activated protein kinase 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: MAPK12

    Clone Names

    • MGC149722, DKFZp761B039

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables acetylputrescine deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables acetylspermidine deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone deacetylase activity TAS
    Traceable Author Statement
    more info
     
    enables histone deacetylase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT enables protein lysine deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein lysine deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    part_of histone deacetylase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    polyamine deacetylase HDAC10
    NP_001152758.1
    NP_114408.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029758.1 RefSeqGene

      Range
      5141..11223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001159286.2NP_001152758.1  polyamine deacetylase HDAC10 isoform 2

      See identical proteins and their annotated locations for NP_001152758.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2, also known as beta) missing an internal protein segment compared to isoform 1.
      Source sequence(s)
      AF407273, AF426160, BC094734
      Consensus CDS
      CCDS54545.1
      UniProtKB/TrEMBL
      C9J8B8
      Related
      ENSP00000343540.4, ENST00000349505.4
      Conserved Domains (1) summary
      cl17011
      Location:18334
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    2. NM_032019.6NP_114408.3  polyamine deacetylase HDAC10 isoform 1

      See identical proteins and their annotated locations for NP_114408.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1, also known as alpha).
      Source sequence(s)
      AF426160, BC094734
      Consensus CDS
      CCDS14088.1
      UniProtKB/Swiss-Prot
      Q08AP4, Q6STF9, Q969S8, Q96P77, Q96P78, Q9H028, Q9UGX1, Q9UGX2
      UniProtKB/TrEMBL
      C9J8B8
      Related
      ENSP00000216271.5, ENST00000216271.10
      Conserved Domains (2) summary
      cd11683
      Location:18354
      HDAC10; Histone deacetylase 10
      cl17011
      Location:562634
      Arginase_HDAC; Arginase-like and histone-like hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      50245183..50251265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      50752185..50758268 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)