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    Nedd4l neural precursor cell expressed, developmentally down-regulated gene 4-like [ Mus musculus (house mouse) ]

    Gene ID: 83814, updated on 12-Mar-2019

    Summary

    Official Symbol
    Nedd4lprovided by MGI
    Official Full Name
    neural precursor cell expressed, developmentally down-regulated gene 4-likeprovided by MGI
    Primary source
    MGI:MGI:1933754
    See related
    Ensembl:ENSMUSG00000024589
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nedd4b; Nedd4-2; 1300012C07Rik
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 4.8), CNS E18 (RPKM 4.7) and 26 other tissues See more
    Orthologs

    Genomic context

    See Nedd4l in Genome Data Viewer
    Location:
    18; 18 E1
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (64887683..65217826)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (65047410..65377480)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 29860 Neighboring gene predicted gene, 46639 Neighboring gene predicted gene, 41756 Neighboring gene predicted gene, 41755 Neighboring gene predicted gene, 29966 Neighboring gene microRNA 122

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 
    • Gene trapped (1) 
    • Targeted (6)  1 citation

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ion channel binding ISO
    Inferred from Sequence Orthology
    more info
     
    potassium channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sodium channel inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sodium channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    sodium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of potassium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of sodium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of sodium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of sodium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cation channel activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of caveolin-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sodium ion transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of bicellular tight junction assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of membrane repolarization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of potassium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    response to metal ion ISO
    Inferred from Sequence Orthology
    more info
     
    response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    ventricular cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase NEDD4-like
    Names
    HECT-type E3 ubiquitin transferase NED4L
    NEDD4.2
    neural precursor cell expressed, developmentally down-regulated gene 4b
    NP_001107858.1
    NP_114087.2
    XP_006526433.1
    XP_006526434.1
    XP_006526436.1
    XP_006526437.1
    XP_006526439.1
    XP_006526440.1
    XP_006526441.1
    XP_006526442.1
    XP_006526443.1
    XP_006526445.1
    XP_011245346.1
    XP_011245349.1
    XP_017173504.1
    XP_017173505.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114386.1NP_001107858.1  E3 ubiquitin-protein ligase NEDD4-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102288, AC102333, AC131709, AC161175
      Consensus CDS
      CCDS50309.1
      UniProtKB/TrEMBL
      E9PXB7
      Related
      ENSMUSP00000132838.1, ENSMUST00000163516.7
      Conserved Domains (6) summary
      cd04033
      Location:21153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:550582
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:643972
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:619973
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:501531
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:388417
      WW; WW domain
    2. NM_031881.2NP_114087.2  E3 ubiquitin-protein ligase NEDD4-like isoform 2

      See identical proteins and their annotated locations for NP_114087.2

      Status: VALIDATED

      Source sequence(s)
      AC102288, AC102333, AC161175
      Consensus CDS
      CCDS29305.1
      UniProtKB/TrEMBL
      G3X9H8
      Related
      ENSMUSP00000079280.4, ENSMUST00000080418.5
      Conserved Domains (6) summary
      smart00456
      Location:429461
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:522851
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:498852
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:380410
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:267296
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      64887683..65217826
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247044.2XP_011245346.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

      See identical proteins and their annotated locations for XP_011245346.1

      UniProtKB/TrEMBL
      G3X9H8
      Conserved Domains (6) summary
      smart00456
      Location:429461
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:522851
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:498852
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:380410
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:267296
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    2. XM_011247047.2XP_011245349.1  E3 ubiquitin-protein ligase NEDD4-like isoform X6

      UniProtKB/TrEMBL
      A0A286YCM8
      Conserved Domains (6) summary
      smart00456
      Location:409441
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:502831
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:478832
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:360390
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:247276
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    3. XM_006526373.3XP_006526436.1  E3 ubiquitin-protein ligase NEDD4-like isoform X3

      Conserved Domains (6) summary
      cd04033
      Location:21153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:530562
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:623952
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:599953
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:481511
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:368397
      WW; WW domain
    4. XM_006526374.3XP_006526437.1  E3 ubiquitin-protein ligase NEDD4-like isoform X4

      See identical proteins and their annotated locations for XP_006526437.1

      Conserved Domains (6) summary
      cd04033
      Location:8140
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:537569
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:630959
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:606960
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:488518
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:375404
      WW; WW domain
    5. XM_006526382.3XP_006526445.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

      See identical proteins and their annotated locations for XP_006526445.1

      UniProtKB/TrEMBL
      G3X9H8
      Conserved Domains (6) summary
      smart00456
      Location:429461
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:522851
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:498852
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:380410
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:267296
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    6. XM_006526376.3XP_006526439.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

      See identical proteins and their annotated locations for XP_006526439.1

      UniProtKB/TrEMBL
      G3X9H8
      Conserved Domains (6) summary
      smart00456
      Location:429461
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:522851
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:498852
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:380410
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:267296
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    7. XM_006526377.3XP_006526440.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

      See identical proteins and their annotated locations for XP_006526440.1

      UniProtKB/TrEMBL
      G3X9H8
      Conserved Domains (6) summary
      smart00456
      Location:429461
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:522851
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:498852
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:380410
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:267296
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    8. XM_017318015.1XP_017173504.1  E3 ubiquitin-protein ligase NEDD4-like isoform X6

      UniProtKB/TrEMBL
      A0A286YCM8
      Related
      ENSMUSP00000153052.1, ENSMUST00000224347.1
      Conserved Domains (6) summary
      smart00456
      Location:409441
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:502831
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:478832
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:360390
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:247276
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    9. XM_006526370.3XP_006526433.1  E3 ubiquitin-protein ligase NEDD4-like isoform X1

      Conserved Domains (6) summary
      cd04033
      Location:67179
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:576608
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:669998
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:645999
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:527557
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:414443
      WW; WW domain
    10. XM_006526371.3XP_006526434.1  E3 ubiquitin-protein ligase NEDD4-like isoform X2

      Conserved Domains (6) summary
      cd04033
      Location:67179
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:556588
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:649978
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:625979
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:507537
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:394423
      WW; WW domain
    11. XM_006526378.2XP_006526441.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

      See identical proteins and their annotated locations for XP_006526441.1

      UniProtKB/TrEMBL
      G3X9H8
      Related
      ENSMUSP00000153526.1, ENSMUST00000226058.1
      Conserved Domains (6) summary
      smart00456
      Location:429461
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:522851
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:498852
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:380410
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:267296
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    12. XM_006526379.3XP_006526442.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

      See identical proteins and their annotated locations for XP_006526442.1

      UniProtKB/TrEMBL
      G3X9H8
      Conserved Domains (6) summary
      smart00456
      Location:429461
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:522851
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:498852
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:380410
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:267296
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    13. XM_017318016.1XP_017173505.1  E3 ubiquitin-protein ligase NEDD4-like isoform X6

      UniProtKB/TrEMBL
      A0A286YCM8
      Conserved Domains (6) summary
      smart00456
      Location:409441
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:502831
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:478832
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:360390
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:247276
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    14. XM_006526380.2XP_006526443.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

      See identical proteins and their annotated locations for XP_006526443.1

      UniProtKB/TrEMBL
      G3X9H8
      Conserved Domains (6) summary
      smart00456
      Location:429461
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:522851
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:498852
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:380410
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:267296
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain

    RNA

    1. XR_001782406.1 RNA Sequence

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