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    Nedd4l neural precursor cell expressed, developmentally down-regulated gene 4-like [ Mus musculus (house mouse) ]

    Gene ID: 83814, updated on 19-Sep-2021

    Summary

    Official Symbol
    Nedd4lprovided by MGI
    Official Full Name
    neural precursor cell expressed, developmentally down-regulated gene 4-likeprovided by MGI
    Primary source
    MGI:MGI:1933754
    See related
    Ensembl:ENSMUSG00000024589
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nedd4; Nedd4-; Nedd4b; Nedd4-2; 1300012C07Rik
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 4.8), CNS E18 (RPKM 4.7) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Nedd4l in Genome Data Viewer
    Location:
    18; 18 E1
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (65017551..65350897)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (64884480..65217826)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (65047410..65377480)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29860 Neighboring gene predicted gene, 46639 Neighboring gene predicted gene, 41756 Neighboring gene uncharacterized LOC118568359 Neighboring gene microRNA 122 Neighboring gene alpha-kinase 2 Neighboring gene predicted gene, 41757

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables potassium channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sodium channel inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables sodium channel inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sodium channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sodium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of potassium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of sodium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of sodium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of sodium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cation channel activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of sodium ion transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of bicellular tight junction assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of membrane repolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of potassium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to metal ion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase NEDD4-like
    Names
    HECT-type E3 ubiquitin transferase NED4L
    NEDD4.2
    neural precursor cell expressed, developmentally down-regulated gene 4b
    NP_001107858.1
    NP_114087.2
    XP_006526433.1
    XP_006526434.1
    XP_006526436.1
    XP_011245346.1
    XP_011245349.1
    XP_017173504.1
    XP_017173505.1
    XP_030106497.1
    XP_030106501.1
    XP_030106502.1
    XP_030106503.1
    XP_030106504.1
    XP_036017204.1
    XP_036017205.1
    XP_036017206.1
    XP_036017207.1
    XP_036017208.1
    XP_036017209.1
    XP_036017210.1
    XP_036017211.1
    XP_036017212.1
    XP_036017213.1
    XP_036017214.1
    XP_036017215.1
    XP_036017216.1
    XP_036017217.1
    XP_036017218.1
    XP_036017219.1
    XP_036017220.1
    XP_036017221.1
    XP_036017222.1
    XP_036017223.1
    XP_036017224.1
    XP_036017225.1
    XP_036017226.1
    XP_036017227.1
    XP_036017228.1
    XP_036017229.1
    XP_036017230.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114386.1NP_001107858.1  E3 ubiquitin-protein ligase NEDD4-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102288, AC102333, AC131709, AC161175
      Consensus CDS
      CCDS50309.1
      UniProtKB/TrEMBL
      E9PXB7
      Related
      ENSMUSP00000158026.2, ENSMUST00000235343.2
      Conserved Domains (6) summary
      cd04033
      Location:21153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:550582
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:643972
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:619973
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00201
      Location:501531
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:388417
      WW; WW domain
    2. NM_031881.2NP_114087.2  E3 ubiquitin-protein ligase NEDD4-like isoform 2

      See identical proteins and their annotated locations for NP_114087.2

      Status: VALIDATED

      Source sequence(s)
      AC102288, AC102333, AC161175
      Consensus CDS
      CCDS29305.1
      UniProtKB/TrEMBL
      G3X9H8
      Related
      ENSMUSP00000079280.5, ENSMUST00000080418.7
      Conserved Domains (4) summary
      smart00456
      Location:429461
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:522851
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:267296
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      65017551..65350897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161323.1XP_036017216.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

      Conserved Domains (4) summary
      smart00456
      Location:429479
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:540869
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:267296
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    2. XM_036161333.1XP_036017226.1  E3 ubiquitin-protein ligase NEDD4-like isoform X19

      Conserved Domains (4) summary
      smart00456
      Location:409459
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:520849
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:247276
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    3. XM_030250641.1XP_030106501.1  E3 ubiquitin-protein ligase NEDD4-like isoform X20

      Conserved Domains (4) summary
      smart00456
      Location:409441
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:502831
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:247276
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    4. XM_036161325.1XP_036017218.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

      Conserved Domains (4) summary
      smart00456
      Location:429479
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:540869
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:267296
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    5. XM_036161334.1XP_036017227.1  E3 ubiquitin-protein ligase NEDD4-like isoform X19

      Conserved Domains (4) summary
      smart00456
      Location:409459
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:520849
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:247276
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    6. XM_030250643.1XP_030106503.1  E3 ubiquitin-protein ligase NEDD4-like isoform X20

      Conserved Domains (4) summary
      smart00456
      Location:409441
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:502831
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:247276
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    7. XM_036161324.1XP_036017217.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

      Conserved Domains (4) summary
      smart00456
      Location:429479
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:540869
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:267296
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    8. XM_036161332.1XP_036017225.1  E3 ubiquitin-protein ligase NEDD4-like isoform X19

      Conserved Domains (4) summary
      smart00456
      Location:409459
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:520849
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:247276
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    9. XM_030250642.1XP_030106502.1  E3 ubiquitin-protein ligase NEDD4-like isoform X20

      Conserved Domains (4) summary
      smart00456
      Location:409441
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:502831
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:247276
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    10. XM_036161336.1XP_036017229.1  E3 ubiquitin-protein ligase NEDD4-like isoform X21

      Conserved Domains (4) summary
      smart00456
      Location:259291
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:352681
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:77103
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    11. XM_036161321.1XP_036017214.1  E3 ubiquitin-protein ligase NEDD4-like isoform X13

      Conserved Domains (4) summary
      cd04033
      Location:8140
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:537587
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:648977
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:375404
      WW; WW domain
    12. XM_036161322.1XP_036017215.1  E3 ubiquitin-protein ligase NEDD4-like isoform X15

      Conserved Domains (4) summary
      cd04033
      Location:8140
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:517567
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:628957
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:355384
      WW; WW domain
    13. XM_030250637.1XP_030106497.1  E3 ubiquitin-protein ligase NEDD4-like isoform X16

      Conserved Domains (4) summary
      cd04033
      Location:8140
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:517549
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:610939
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:355384
      WW; WW domain
    14. XM_036161326.1XP_036017219.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

      Conserved Domains (4) summary
      smart00456
      Location:429479
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:540869
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:267296
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    15. XM_036161320.1XP_036017213.1  E3 ubiquitin-protein ligase NEDD4-like isoform X11

      Conserved Domains (4) summary
      cd04033
      Location:14146
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:543593
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:654983
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:381410
      WW; WW domain
    16. XM_036161327.1XP_036017220.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

      Conserved Domains (4) summary
      smart00456
      Location:429479
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:540869
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:267296
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    17. XM_011247044.3XP_011245346.1  E3 ubiquitin-protein ligase NEDD4-like isoform X18

      See identical proteins and their annotated locations for XP_011245346.1

      UniProtKB/TrEMBL
      G3X9H8
      Conserved Domains (4) summary
      smart00456
      Location:429461
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:522851
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:267296
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    18. XM_036161335.1XP_036017228.1  E3 ubiquitin-protein ligase NEDD4-like isoform X19

      Conserved Domains (4) summary
      smart00456
      Location:409459
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:520849
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:247276
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    19. XM_011247047.3XP_011245349.1  E3 ubiquitin-protein ligase NEDD4-like isoform X20

      UniProtKB/TrEMBL
      A0A286YCM8
      Conserved Domains (4) summary
      smart00456
      Location:409441
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:502831
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:247276
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    20. XM_036161318.1XP_036017211.1  E3 ubiquitin-protein ligase NEDD4-like isoform X9

      Conserved Domains (4) summary
      cd04033
      Location:21153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:550600
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:661990
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:388417
      WW; WW domain
    21. XM_036161319.1XP_036017212.1  E3 ubiquitin-protein ligase NEDD4-like isoform X10

      Conserved Domains (4) summary
      cd04033
      Location:21153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:530580
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:641970
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:368397
      WW; WW domain
    22. XM_006526373.3XP_006526436.1  E3 ubiquitin-protein ligase NEDD4-like isoform X14

      Related
      ENSMUSP00000157490.2, ENSMUST00000236736.2
      Conserved Domains (4) summary
      cd04033
      Location:21153
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:530562
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:623952
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:368397
      WW; WW domain
    23. XM_036161328.1XP_036017221.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

      Conserved Domains (4) summary
      smart00456
      Location:429479
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:540869
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:267296
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    24. XM_017318015.2XP_017173504.1  E3 ubiquitin-protein ligase NEDD4-like isoform X20

      UniProtKB/TrEMBL
      A0A286YCM8
      Related
      ENSMUSP00000157910.2, ENSMUST00000237854.2
      Conserved Domains (4) summary
      smart00456
      Location:409441
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:502831
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:247276
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    25. XM_006526370.4XP_006526433.1  E3 ubiquitin-protein ligase NEDD4-like isoform X7

      Conserved Domains (4) summary
      cd04033
      Location:67179
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:576608
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:669998
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:414443
      WW; WW domain
    26. XM_036161317.1XP_036017210.1  E3 ubiquitin-protein ligase NEDD4-like isoform X8

      Conserved Domains (4) summary
      cd04033
      Location:67179
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:556606
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:667996
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:394423
      WW; WW domain
    27. XM_006526371.4XP_006526434.1  E3 ubiquitin-protein ligase NEDD4-like isoform X12

      Conserved Domains (4) summary
      cd04033
      Location:67179
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:556588
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:649978
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:394423
      WW; WW domain
    28. XM_036161337.1XP_036017230.1  E3 ubiquitin-protein ligase NEDD4-like isoform X21

      Related
      ENSMUSP00000157658.2, ENSMUST00000236103.2
      Conserved Domains (4) summary
      smart00456
      Location:259291
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:352681
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:77103
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    29. XM_036161329.1XP_036017222.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

      Conserved Domains (4) summary
      smart00456
      Location:429479
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:540869
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:267296
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    30. XM_030250644.2XP_030106504.1  E3 ubiquitin-protein ligase NEDD4-like isoform X20

      Related
      ENSMUSP00000132838.3, ENSMUST00000163516.9
      Conserved Domains (4) summary
      smart00456
      Location:409441
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:502831
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:247276
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    31. XM_036161330.1XP_036017223.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

      Conserved Domains (4) summary
      smart00456
      Location:429479
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:540869
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:267296
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    32. XM_017318016.2XP_017173505.1  E3 ubiquitin-protein ligase NEDD4-like isoform X20

      UniProtKB/TrEMBL
      A0A286YCM8
      Conserved Domains (4) summary
      smart00456
      Location:409441
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:502831
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:247276
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
    33. XM_036161315.1XP_036017208.1  E3 ubiquitin-protein ligase NEDD4-like isoform X5

      Conserved Domains (5) summary
      smart00456
      Location:647697
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:7581087
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      PHA03307
      Location:83316
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00397
      Location:465491
      WW; WW domain
      cl14603
      Location:367420
      C2; C2 domain
    34. XM_036161316.1XP_036017209.1  E3 ubiquitin-protein ligase NEDD4-like isoform X6

      Conserved Domains (5) summary
      smart00456
      Location:647679
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:7401069
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      PHA03307
      Location:83316
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00397
      Location:465491
      WW; WW domain
      cl14603
      Location:367420
      C2; C2 domain
    35. XM_036161311.1XP_036017204.1  E3 ubiquitin-protein ligase NEDD4-like isoform X1

      Conserved Domains (6) summary
      smart00456
      Location:817867
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:9281257
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      PHA03378
      Location:107318
      PHA03378; EBNA-3B; Provisional
      cd00201
      Location:768798
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:655684
      WW; WW domain
      cl14603
      Location:367420
      C2; C2 domain
    36. XM_036161312.1XP_036017205.1  E3 ubiquitin-protein ligase NEDD4-like isoform X2

      Conserved Domains (6) summary
      smart00456
      Location:817849
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:9101239
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      PHA03378
      Location:107318
      PHA03378; EBNA-3B; Provisional
      cd00201
      Location:768798
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:655684
      WW; WW domain
      cl14603
      Location:367420
      C2; C2 domain
    37. XM_036161313.1XP_036017206.1  E3 ubiquitin-protein ligase NEDD4-like isoform X3

      Conserved Domains (6) summary
      smart00456
      Location:797847
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:9081237
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      PHA03307
      Location:83316
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00201
      Location:748778
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:635664
      WW; WW domain
      cl14603
      Location:367420
      C2; C2 domain
    38. XM_036161314.1XP_036017207.1  E3 ubiquitin-protein ligase NEDD4-like isoform X4

      Conserved Domains (6) summary
      smart00456
      Location:797829
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:8901219
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      PHA03307
      Location:83316
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00201
      Location:748778
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:635664
      WW; WW domain
      cl14603
      Location:367420
      C2; C2 domain
    39. XM_036161331.1XP_036017224.1  E3 ubiquitin-protein ligase NEDD4-like isoform X17

      Conserved Domains (4) summary
      smart00456
      Location:429479
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:540869
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:267296
      WW; WW domain
      cl14603
      Location:132
      C2; C2 domain
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