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    Nsfl1c NSFL1 cofactor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83809, updated on 10-Oct-2024

    Summary

    Official Symbol
    Nsfl1cprovided by RGD
    Official Full Name
    NSFL1 cofactorprovided by RGD
    Primary source
    RGD:619952
    See related
    EnsemblRapid:ENSRNOG00000008604 AllianceGenome:RGD:619952
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    p47; XY40
    Summary
    Enables ATPase binding activity and ubiquitin binding activity. Contributes to phospholipid binding activity. Involved in Golgi organization and membrane fusion. Located in cytosol and spindle pole centrosome. Part of VCP-NSFL1C complex. Orthologous to human NSFL1C (NSFL1 cofactor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 311.9), Muscle (RPKM 288.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nsfl1c in Genome Data Viewer
    Location:
    3q41
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (160438708..160463261)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (139978306..140002876)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (146980923..147005478)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101748 Neighboring gene uncharacterized LOC102548446 Neighboring gene nuclear factor kappa B subunit 2, pseudogene 1 Neighboring gene uncharacterized LOC102548575 Neighboring gene FKBP prolyl isomerase 1A Neighboring gene syndecan binding protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Golgi organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of mitotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in membrane fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear membrane reassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of mitotic centrosome separation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi stack IEA
    Inferred from Electronic Annotation
    more info
     
    part_of VCP-NSFL1C complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of VCP-NSFL1C complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of VCP-NSFL1C complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle pole centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    NSFL1 cofactor p47
    Names
    NSFL1 (p97) cofactor (p47)
    XY body-associated protein XY40
    p97 cofactor p47

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031981.2NP_114187.1  NSFL1 cofactor p47

      See identical proteins and their annotated locations for NP_114187.1

      Status: PROVISIONAL

      Source sequence(s)
      AB002086
      UniProtKB/Swiss-Prot
      O35987
      UniProtKB/TrEMBL
      A0A0G2K911, A6KHI1
      Related
      ENSRNOP00000074814.2, ENSRNOT00000090211.3
      Conserved Domains (3) summary
      smart00553
      Location:178270
      SEP; Domain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47
      cd14348
      Location:745
      UBA_p47; UBA-like domain found in NSFL1 cofactor p47 and similar proteins
      cd17162
      Location:289370
      UBX_UBXN2C; Ubiquitin regulatory domain X (UBX) found in NSFL1 cofactor (also known as UBX domain-containing protein 2C (UBXN2C) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      160438708..160463261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284677.1XP_063140747.1  NSFL1 cofactor p47 isoform X1

      UniProtKB/TrEMBL
      A6KHI3