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    Smarcd2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 83796, updated on 24-Aug-2021

    Summary

    Official Symbol
    Smarcd2provided by MGI
    Official Full Name
    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2provided by MGI
    Primary source
    MGI:MGI:1933621
    See related
    Ensembl:ENSMUSG00000078619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Baf60; Baf60b; AW322457
    Expression
    Ubiquitous expression in thymus adult (RPKM 97.9), adrenal adult (RPKM 42.3) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Smarcd2 in Genome Data Viewer
    Location:
    11; 11 E1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106153997..106163810, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106263171..106272998, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (106124485..106134286, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene DEAD box helicase 42 Neighboring gene FtsJ RNA methyltransferase homolog 3 (E. coli) Neighboring gene protease (prosome, macropain) 26S subunit, ATPase 5 Neighboring gene predicted gene, 23645 Neighboring gene testicular cell adhesion molecule 1 Neighboring gene growth hormone

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleosome disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SWI/SNF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of SWI/SNF complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SWI/SNF superfamily-type complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
    Names
    60 kDa BRG-1/Brm-associated factor subunit B
    BRG1-associated factor 60B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130187.1NP_001123659.1  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 isoform 1

      See identical proteins and their annotated locations for NP_001123659.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK159259, BB642181, BE853586, DV648475
      Consensus CDS
      CCDS48958.1
      UniProtKB/Swiss-Prot
      Q99JR8
      UniProtKB/TrEMBL
      Q3TXH6
      Related
      ENSMUSP00000021052.10, ENSMUST00000021052.16
      Conserved Domains (2) summary
      COG5531
      Location:230425
      Rsc6; Chromatin remodeling complex protein RSC6, contains SWIB domain [Chromatin structure and dynamics]
      pfam02201
      Location:310381
      SWIB; SWIB/MDM2 domain
    2. NM_031878.2NP_114084.2  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK159259, BE853586, CO425905, DV648475
      Consensus CDS
      CCDS48957.1
      UniProtKB/TrEMBL
      Q3TXH6
      Related
      ENSMUSP00000102456.2, ENSMUST00000106843.8
      Conserved Domains (2) summary
      COG5531
      Location:183378
      Rsc6; Chromatin remodeling complex protein RSC6, contains SWIB domain [Chromatin structure and dynamics]
      pfam02201
      Location:263334
      SWIB; SWIB/MDM2 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      106153997..106163810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534552.5XP_006534615.2  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 isoform X1

      Conserved Domains (3) summary
      TIGR01628
      Location:43161
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      COG5531
      Location:250445
      Rsc6; Chromatin remodeling complex protein RSC6, contains SWIB domain [Chromatin structure and dynamics]
      cd17675
      Location:327406
      SWIB_BAF60B; SWIB domain found in BRG1-associated factor 60B (BAF60B) and similar proteins
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