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    ARMC10 armadillo repeat containing 10 [ Homo sapiens (human) ]

    Gene ID: 83787, updated on 22-Sep-2022

    Summary

    Official Symbol
    ARMC10provided by HGNC
    Official Full Name
    armadillo repeat containing 10provided by HGNC
    Primary source
    HGNC:HGNC:21706
    See related
    Ensembl:ENSG00000170632 MIM:611864; AllianceGenome:HGNC:21706
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SVH; PNAS112; PNAS-112; PSEC0198
    Summary
    This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Sep 2011]
    Expression
    Ubiquitous expression in thyroid (RPKM 11.8), adrenal (RPKM 9.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ARMC10 in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (103075140..103099759)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (104390256..104414903)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102715587..102740206)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene F-box and leucine rich repeat protein 13 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:102631963-102633162 Neighboring gene Sharpr-MPRA regulatory region 7515 Neighboring gene crystallin zeta pseudogene 1 Neighboring gene N-acyl phosphatidylethanolamine phospholipase D Neighboring gene uncharacterized LOC105375434 Neighboring gene ribosomal protein L19 pseudogene 12 Neighboring gene ribosomal protein L23a pseudogene 95

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC3195, FLJ37850

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    armadillo repeat-containing protein 10
    Names
    specific splicing variant involved in hepatocarcinogenesis
    splicing variant involved in hepatocarcinogenesis protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030014.1 RefSeqGene

      Range
      5260..29879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001161009.3NP_001154481.1  armadillo repeat-containing protein 10 isoform b

      See identical proteins and their annotated locations for NP_001154481.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (B) lacks an in-frame exon in the 5' coding region compared to variant A. This results in a shorter protein (isoform b) compared to isoform a.
      Source sequence(s)
      AI761577, AY150851, AY150853, BM989172, BQ004061, BQ440425, BU941174
      Consensus CDS
      CCDS55146.1
      UniProtKB/Swiss-Prot
      Q8N2F6
      Related
      ENSP00000413619.2, ENST00000441711.6
      Conserved Domains (3) summary
      cd00020
      Location:55140
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam04826
      Location:52302
      Arm_2; Armadillo-like
      sd00043
      Location:5684
      ARM; armadillo repeat [structural motif]
    2. NM_001161010.3NP_001154482.1  armadillo repeat-containing protein 10 isoform c

      See identical proteins and their annotated locations for NP_001154482.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (C) lacks an in-frame exon in the 3' coding region compared to variant A. This results in a shorter protein (isoform c) compared to isoform a.
      Source sequence(s)
      AI761577, AY150851, AY150852, BM989172, BQ004061, BQ440425, BU941174
      Consensus CDS
      CCDS55145.1
      UniProtKB/Swiss-Prot
      Q8N2F6
      Related
      ENSP00000396654.2, ENST00000428183.6
      Conserved Domains (3) summary
      cd00020
      Location:90186
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam04826
      Location:87278
      Arm_2; Armadillo-like
      sd00043
      Location:91119
      ARM; armadillo repeat [structural motif]
    3. NM_001161011.3NP_001154483.1  armadillo repeat-containing protein 10 isoform e

      See identical proteins and their annotated locations for NP_001154483.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (E) lacks two in-frame exons in the coding region compared to variant A. This results in a shorter protein (isoform e) compared to isoform a.
      Source sequence(s)
      AI761577, AK301565, AY150851, BM989172, BQ004061, BQ440425, BU941174
      Consensus CDS
      CCDS55147.1
      UniProtKB/Swiss-Prot
      Q8N2F6
      Related
      ENSP00000397969.1, ENST00000425331.5
      Conserved Domains (3) summary
      cd00020
      Location:55140
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam04826
      Location:52278
      Arm_2; Armadillo-like
      sd00043
      Location:5684
      ARM; armadillo repeat [structural motif]
    4. NM_001161012.3NP_001154484.1  armadillo repeat-containing protein 10 isoform d

      See identical proteins and their annotated locations for NP_001154484.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (D) lacks two in-frame exons in the coding region compared to variant A. This results in a shorter protein (isoform d) compared to isoform a.
      Source sequence(s)
      AI761577, AY150851, BM989172, BQ004061, BQ440425, BU941174
      Consensus CDS
      CCDS55148.1
      UniProtKB/Swiss-Prot
      Q8N2F6
      Related
      ENSP00000405612.1, ENST00000454559.5
      Conserved Domains (3) summary
      cd00020
      Location:55151
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam04826
      Location:52243
      Arm_2; Armadillo-like
      sd00043
      Location:5684
      ARM; armadillo repeat [structural motif]
    5. NM_001161013.3NP_001154485.1  armadillo repeat-containing protein 10 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (F) lacks three in-frame exons in the coding region compared to variant A. This results in a shorter protein (isoform f) compared to isoform a.
      Source sequence(s)
      AF275808, AI761577, AY150851, BM989172, BQ004061, BQ440425, BU941174
      Consensus CDS
      CCDS55149.1
      UniProtKB/Swiss-Prot
      Q8N2F6
      Related
      ENSP00000440463.1, ENST00000541300.5
      Conserved Domains (3) summary
      cd00020
      Location:55169
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam04826
      Location:52219
      Arm_2; Armadillo-like
      sd00043
      Location:5684
      ARM; armadillo repeat [structural motif]
    6. NM_031905.5NP_114111.2  armadillo repeat-containing protein 10 isoform a

      See identical proteins and their annotated locations for NP_114111.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AI761577, AY150851, AY150854, BM989172, BQ004061, BQ440425, BU941174
      Consensus CDS
      CCDS5728.1
      UniProtKB/Swiss-Prot
      Q8N2F6, Q9BTM6
      Related
      ENSP00000319412.3, ENST00000323716.8
      Conserved Domains (3) summary
      cd00020
      Location:90175
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam04826
      Location:87337
      Arm_2; Armadillo-like
      sd00043
      Location:91119
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      103075140..103099759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516601.4XP_011514903.1  armadillo repeat-containing protein 10 isoform X8

      Conserved Domains (3) summary
      cd00020
      Location:63148
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam04826
      Location:60310
      Arm_2; Armadillo-like
      sd00043
      Location:6492
      ARM; armadillo repeat [structural motif]
    2. XM_047420912.1XP_047276868.1  armadillo repeat-containing protein 10 isoform X1

    3. XM_047420914.1XP_047276870.1  armadillo repeat-containing protein 10 isoform X3

    4. XM_047420915.1XP_047276871.1  armadillo repeat-containing protein 10 isoform X6

    5. XM_047420913.1XP_047276869.1  armadillo repeat-containing protein 10 isoform X2

    6. XM_047420917.1XP_047276873.1  armadillo repeat-containing protein 10 isoform X9

    7. XM_017012684.3XP_016868173.1  armadillo repeat-containing protein 10 isoform X4

      Conserved Domains (3) summary
      cd00020
      Location:99184
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam04826
      Location:96346
      Arm_2; Armadillo-like
      sd00043
      Location:100128
      ARM; armadillo repeat [structural motif]
    8. XM_017012685.3XP_016868174.1  armadillo repeat-containing protein 10 isoform X5

    9. XM_047420916.1XP_047276872.1  armadillo repeat-containing protein 10 isoform X7

    10. XM_017012688.3XP_016868177.1  armadillo repeat-containing protein 10 isoform X10

    11. XM_005250628.4XP_005250685.1  armadillo repeat-containing protein 10 isoform X11

      UniProtKB/TrEMBL
      H7BXQ8
      Related
      ENSP00000319798.6, ENST00000323735.10
      Conserved Domains (2) summary
      cd00020
      Location:90175
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:91119
      ARM; armadillo repeat [structural motif]
    12. XM_047420918.1XP_047276874.1  armadillo repeat-containing protein 10 isoform X10

    13. XM_017012689.3XP_016868178.1  armadillo repeat-containing protein 10 isoform X12

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187559.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      144970..158099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      104390256..104414903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)