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    Vegfa vascular endothelial growth factor A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83785, updated on 10-Jul-2024

    Summary

    Official Symbol
    Vegfaprovided by RGD
    Official Full Name
    vascular endothelial growth factor Aprovided by RGD
    Primary source
    RGD:619991
    See related
    EnsemblRapid:ENSRNOG00000019598 AllianceGenome:RGD:619991
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    VPF; Vegf; VEGF-A; VEGF111; VEGF164
    Summary
    This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]
    Expression
    Biased expression in Lung (RPKM 1035.8), Heart (RPKM 646.4) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Vegfa in Genome Data Viewer
    Location:
    9q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (22452854..22468194)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14955300..14970641)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (17340341..17355681)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480341 Neighboring gene uncharacterized LOC134480342 Neighboring gene uncharacterized LOC134480343 Neighboring gene uncharacterized LOC102550162

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chemoattractant activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chemoattractant activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables chemoattractant activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables chemoattractant activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables fibronectin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables neuropilin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables platelet-derived growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables platelet-derived growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane receptor protein tyrosine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein tyrosine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables vascular endothelial growth factor receptor 1 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables vascular endothelial growth factor receptor 1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables vascular endothelial growth factor receptor 2 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables vascular endothelial growth factor receptor 2 binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables vascular endothelial growth factor receptor 2 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables vascular endothelial growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables vascular endothelial growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables vascular endothelial growth factor receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T-helper 1 type immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in VEGF-activated neuropilin signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in angiogenesis involved in coronary vascular morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within artery morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in basophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within blood vessel development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within blood vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within bone trabecula formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within bone trabecula morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in branching involved in blood vessel morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within branching involved in blood vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in branching involved in blood vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within camera-type eye morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac vascular smooth muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration involved in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to dexamethasone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to estrogen stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to fibroblast growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to vascular endothelial growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to wortmannin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular stress response to acid chemical IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular stress response to acid chemical ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in commissural neuron axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in commissural neuron axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in coronary artery morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in coronary vein morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within dopaminergic neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelial cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within epithelial cell maturation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within eye photoreceptor cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within homeostasis of number of cells within a tissue ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in induction of positive chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in induction of positive chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lactation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lung vasculature development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lymph vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of lymphangiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lymphangiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in macrophage differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in macrophage differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mammary gland alveolus development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mesoderm development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in motor neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in motor neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of adherens junction organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of adherens junction organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of blood-brain barrier permeability IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of blood-brain barrier permeability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell-cell adhesion mediated by cadherin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell-cell adhesion mediated by cadherin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of establishment of endothelial barrier IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nervous system development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nervous system development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in outflow tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in positive regulation of axon extension involved in axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of axon extension involved in axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of branching involved in ureteric bud morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration involved in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of endothelial cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of endothelial cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial tube formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of focal adhesion assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of focal adhesion assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of lymphangiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mast cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of mast cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of p38MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of peptidyl-tyrosine autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of positive chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase C signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein kinase C signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein-containing complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in positive regulation of receptor signaling pathway via STAT ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of trophoblast cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of trophoblast cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular endothelial growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular endothelial growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular permeability IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular permeability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of vascular permeability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular permeability ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within post-embryonic camera-type eye development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within primitive erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of endothelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of growth ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of nitric oxide mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of nitric oxide mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to dexamethasone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to folic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to oxygen levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to progesterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to vitamin A IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    NOT involved_in retinal ganglion cell axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retinal ganglion cell axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within surfactant homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tissue remodeling IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in tube formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tube formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tube formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vascular endothelial growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vascular endothelial growth factor receptor-2 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vascular endothelial growth factor receptor-2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vascular endothelial growth factor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vascular endothelial growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vascular wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vascular wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within vasculature development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within vasodilation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of VEGF-A complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of VEGF-A complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    vascular endothelial growth factor A
    Names
    vascular permeability factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110333.2NP_001103803.1  vascular endothelial growth factor A isoform 2

      See identical proteins and their annotated locations for NP_001103803.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame, internal coding exon, compared to variant 1. This variant can initiate translation from non-AUG (CUG) site, and also from a downstream, in-frame AUG site. The isoform (2) represented in this RefSeq is derived from the CUG start codon and it lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      BC168708, CO565920, JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K6Z7, B5DEK7
      Related
      ENSRNOP00000106539.1, ENSRNOT00000131972.1
      Conserved Domains (2) summary
      smart00141
      Location:228310
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam14554
      Location:316369
      VEGF_C; VEGF heparin-binding domain
    2. NM_001110334.2NP_001103804.1  vascular endothelial growth factor A isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two consecutive in-frame exons in the 3' coding region, compared to variant 1. This variant can initiate translation from non-AUG (CUG) site, and also from a downstream, in-frame AUG site. The isoform (3) represented in this RefSeq is derived from the CUG start codon and it lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AF215726, BC168708, CO565920, JAXUCZ010000009
      UniProtKB/TrEMBL
      F8WG85
      Related
      ENSRNOP00000050127.4, ENSRNOT00000044163.6
      Conserved Domains (1) summary
      smart00141
      Location:228310
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    3. NM_001110335.1NP_001103805.1  vascular endothelial growth factor A isoform 4

      See identical proteins and their annotated locations for NP_001103805.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1. This variant has transcript support, but the protein is predicted.
      Source sequence(s)
      BQ203400, CK357826, CK358638, CK364938, CK602714, CV107730
      UniProtKB/TrEMBL
      A6JIV9, Q63672, Q63882
      Conserved Domains (2) summary
      pfam14554
      Location:61109
      VEGF_C; VEGF heparin-binding domain
      cl00116
      Location:126
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
    4. NM_001110336.1NP_001103806.1  vascular endothelial growth factor A isoform 5

      See identical proteins and their annotated locations for NP_001103806.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks a portion of the 5' coding region and an in-frame, internal coding exon, compared to variant 1. The resulting isoform (5) has a shorter N-terminus and lacks an internal segment, compared to isoform 1. This variant has transcript support, but the protein is predicted.
      Source sequence(s)
      BQ203400, CK357826, CK358638, CK364938, CK602714, CV107730
      UniProtKB/TrEMBL
      A6JIW0, B4XHA2
      Conserved Domains (2) summary
      pfam14554
      Location:3285
      VEGF_C; VEGF heparin-binding domain
      cl00116
      Location:126
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
    5. NM_001287107.1NP_001274036.1  vascular endothelial growth factor A isoform 6 precursor

      See identical proteins and their annotated locations for NP_001274036.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. This variant can initiate translation from non-AUG (CUG) site, and also from a downstream, in-frame AUG site. The isoform (6) represented in this RefSeq is derived from the AUG start codon and it is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AF215725, BC168708, CO565920, JAXUCZ010000009
      UniProtKB/Swiss-Prot
      P16612, Q541S6, Q91ZE1, Q9JKX7, Q9QXG6, Q9QXG7
      UniProtKB/TrEMBL
      A0A8I5ZN58, A6JIU4
      Conserved Domains (2) summary
      smart00141
      Location:49131
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam14554
      Location:166214
      VEGF_C; VEGF heparin-binding domain
    6. NM_001287108.1NP_001274037.1  vascular endothelial growth factor A isoform Vegf-A precursor

      See identical proteins and their annotated locations for NP_001274037.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame, internal coding exon compared to variant 1. It can initiate translation from a non-AUG (CUG) codon, and also from an in-frame, downstream AUG start codon. The isoform (Vegf-A) represented in this RefSeq is derived from the AUG start codon. It has a shorter N-terminus and lacks an internal protein segment compared to isoform 1. This variant also encodes a C-terminally extended isoform (Vegf-Ax), which results from the use of an alternative in-frame, downstream translation termination codon (UAA). Isoform Vegf-Ax is represented in NM_001317043.1.
      Source sequence(s)
      BC168708, CO565920, JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JIU7, C9DRV0
      Conserved Domains (2) summary
      smart00141
      Location:49131
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam14554
      Location:137190
      VEGF_C; VEGF heparin-binding domain
    7. NM_001287110.1NP_001274039.1  vascular endothelial growth factor A isoform 8 precursor

      See identical proteins and their annotated locations for NP_001274039.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two consecutive in-frame exons in the 3' coding region, compared to variant 1. This variant can initiate translation from non-AUG (CUG) site, and also from a downstream, in-frame AUG site. The isoform (8) represented in this RefSeq is derived from the AUG start codon and it is shorter at the N-terminus and lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AF215726, BC168708, CO565920, JAXUCZ010000009
      UniProtKB/TrEMBL
      Q541S7, Q64FZ6
      Conserved Domains (1) summary
      smart00141
      Location:49131
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    8. NM_001287111.1NP_001274040.1  vascular endothelial growth factor A isoform 9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an in-frame, internal exon in the 3' coding region, compared to variant 1. This variant can initiate translation from non-AUG (CUG) site, and also from a downstream, in-frame AUG site. The isoform (9) represented in this RefSeq is derived from the CUG start codon and it lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AF222779, BC168708, CO565920, JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0H2UHY5
      Conserved Domains (1) summary
      smart00141
      Location:228310
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    9. NM_001287112.1NP_001274041.1  vascular endothelial growth factor A isoform 10 precursor

      See identical proteins and their annotated locations for NP_001274041.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an in-frame, internal exon in the 3' coding region, compared to variant 1. This variant can initiate translation from non-AUG (CUG) site, and also from a downstream, in-frame AUG site. The isoform (10) represented in this RefSeq is derived from the AUG start codon and it is shorter at the N-terminus and lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AF222779, BC168708, CO565920, JAXUCZ010000009
      UniProtKB/TrEMBL
      Q64FZ6
      Related
      ENSRNOP00000047820.4, ENSRNOT00000042790.5
      Conserved Domains (1) summary
      smart00141
      Location:49131
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    10. NM_001287113.1NP_001274042.1  vascular endothelial growth factor A isoform 11

      See identical proteins and their annotated locations for NP_001274042.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an internal exon in the 5' region, which results in translation initiation at a downstream AUG site, and an in-frame, internal coding exon, compared to variant 1. The resulting isoform (11) is shorter at the N-terminus and lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AY378102, BC168708, CO565920, JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JIV1, C9DRV0
      Conserved Domains (2) summary
      smart00141
      Location:789
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam14554
      Location:95148
      VEGF_C; VEGF heparin-binding domain
    11. NM_001287114.1NP_001274043.1  vascular endothelial growth factor A isoform 12

      See identical proteins and their annotated locations for NP_001274043.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an internal exon in the 5' region, which results in translation initiation at a downstream AUG site, and two consecutive in-frame exons in the 3' coding region, compared to variant 1. The resulting isoform (12) is shorter at the N-terminus and lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AF215726, AY378102, BC168708, CO565920, JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JIV5
      Conserved Domains (1) summary
      smart00141
      Location:789
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    12. NM_001317043.1NP_001303972.1  vascular endothelial growth factor A isoform Vegf-Ax precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is identical to NM_001287108.1; however, it uses an alternative in-frame, downstream translation termination codon (UAA), which results in a longer, C-terminally extended isoform (Vegf-Ax) compared to isoform Vegf-A. Unlike isoform Vegf-A, which is proangiogenic, Vegf-Ax exhibits antiangiogenic activity. As the upstream UGA stop codon has been shown to be recoded as serine (PMID:24949972), its location in the Vegf-Ax isoform (aa 191) is denoted by an 'S'.
      Source sequence(s)
      BC168708, CO565920, JAXUCZ010000009
      UniProtKB/TrEMBL
      B5DEK7
      Conserved Domains (2) summary
      smart00141
      Location:49131
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam14554
      Location:142190
      VEGF_C; VEGF heparin-binding domain
    13. NM_031836.3NP_114024.2  vascular endothelial growth factor A isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. This variant can initiate translation from non-AUG (CUG) site, and also from a downstream, in-frame AUG site. The isoform (1) represented in this RefSeq is derived from the CUG start codon and it is the longest isoform.
      Source sequence(s)
      AF215725, BC168708, CO565920, JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0H2UHY5
      Related
      ENSRNOP00000026637.5, ENSRNOT00000026637.9
      Conserved Domains (1) summary
      smart00141
      Location:228310
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

    RNA

    1. NR_105011.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) has an alternate splice site and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AY702972, BC168708, CO565920, JAXUCZ010000009
      Related
      ENSRNOT00000026559.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      22452854..22468194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)