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    RBP5 retinol binding protein 5 [ Homo sapiens (human) ]

    Gene ID: 83758, updated on 17-Jun-2024

    Summary

    Official Symbol
    RBP5provided by HGNC
    Official Full Name
    retinol binding protein 5provided by HGNC
    Primary source
    HGNC:HGNC:15847
    See related
    Ensembl:ENSG00000139194 MIM:611866; AllianceGenome:HGNC:15847
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRBP3; CRBPIII; HRBPiso; CRBP-III
    Summary
    The protein encoded by this gene is a cellular retinol-binding protein expressed highly in kidney and liver. Down-regulation of the encoded protein in hepatocellular carcinoma was associated with large tumor size and poor patient survival rates. [provided by RefSeq, Jul 2016]
    Expression
    Biased expression in kidney (RPKM 131.3), liver (RPKM 58.1) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RBP5 in Genome Data Viewer
    Location:
    12p13.31
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (7115736..7130005, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (7130477..7143159, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (7276282..7282601, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7188509-7189008 Neighboring gene Sharpr-MPRA regulatory region 13442 Neighboring gene complement C1r Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:7260830-7262029 Neighboring gene complement C1r subcomponent like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7265863-7266364 Neighboring gene C1RL antisense RNA 1 Neighboring gene RNA, U6 small nuclear 485, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7283265-7283766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4199 Neighboring gene calsyntenin 3 Neighboring gene Sharpr-MPRA regulatory region 5519 Neighboring gene uncharacterized LOC124902869 Neighboring gene MPRA-validated peak1553 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7340767-7341268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7341269-7341768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5916 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:7342139-7342855 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:7342856-7343571 Neighboring gene peroxisomal biogenesis factor 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables retinal binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables retinoid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables retinol binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in fatty acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular exosome HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    retinol-binding protein 5
    Names
    cellular retinol-binding protein III
    putative cellular retinol-binding protein CRBP III
    retinol binding protein 5, cellular

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329454.2NP_001316383.1  retinol-binding protein 5 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC018653, AC233309
    2. NM_031491.4NP_113679.1  retinol-binding protein 5 isoform 1

      See identical proteins and their annotated locations for NP_113679.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AA912830, BC029355
      Consensus CDS
      CCDS8574.1
      UniProtKB/Swiss-Prot
      P82980, Q53FB1
      Related
      ENSP00000266560.3, ENST00000266560.8
      Conserved Domains (1) summary
      pfam00061
      Location:6105
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      7115736..7130005 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020002.2XP_016875491.1  retinol-binding protein 5 isoform X1

      Conserved Domains (1) summary
      pfam00061
      Location:1492
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    2. XM_047429633.1XP_047285589.1  retinol-binding protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A0B4J233
      Related
      ENSP00000438083.1, ENST00000542370.1

    RNA

    1. XR_007063133.1 RNA Sequence

    2. XR_001748882.2 RNA Sequence

    3. XR_007063132.1 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160008.1 Reference GRCh38.p14 PATCHES

      Range
      44978..57956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332544.1XP_054188519.1  retinol-binding protein 5 isoform X1

    2. XM_054332545.1XP_054188520.1  retinol-binding protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A0B4J233

    RNA

    1. XR_008485780.1 RNA Sequence

    2. XR_008485778.1 RNA Sequence

    3. XR_008485779.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      7130477..7143159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373385.1XP_054229360.1  retinol-binding protein 5 isoform X1

    2. XM_054373386.1XP_054229361.1  retinol-binding protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A0B4J233

    RNA

    1. XR_008488690.1 RNA Sequence

    2. XR_008488688.1 RNA Sequence

    3. XR_008488689.1 RNA Sequence