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    Srrt serrate RNA effector molecule homolog (Arabidopsis) [ Mus musculus (house mouse) ]

    Gene ID: 83701, updated on 23-Jun-2021

    Summary

    Official Symbol
    Srrtprovided by MGI
    Official Full Name
    serrate RNA effector molecule homolog (Arabidopsis)provided by MGI
    Primary source
    MGI:MGI:1933527
    See related
    Ensembl:ENSMUSG00000037364
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A; Ars2; Asr2; ASR2A; ASR2B; ASR2C; ASR2D; 2810019G02Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 42.3), thymus adult (RPKM 37.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Srrt in Genome Data Viewer
    Location:
    5; 5 G2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137293966..137306564, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137295704..137307716, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (137736932..137748902, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene acetylcholinesterase Neighboring gene microRNA 8116 Neighboring gene UFM1-specific peptidase 1 Neighboring gene microRNA 7036 Neighboring gene predicted gene 43013 Neighboring gene thyroid hormone receptor interactor 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA cap binding complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuronal stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in primary miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in primary miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serrate RNA effector molecule homolog
    Names
    arsenate resistance protein 2
    arsenite-resistance protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109909.1NP_001103379.1  serrate RNA effector molecule homolog isoform 2

      See identical proteins and their annotated locations for NP_001103379.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different acceptor splice site at the penultimate exon compared to transcript variant 1, resulting in a shorter isoform (2) missing a 7 aa segment, compared to isoform 1.
      Source sequence(s)
      AA986426, BC066831, CJ175065
      Consensus CDS
      CCDS80440.1
      UniProtKB/Swiss-Prot
      Q99MR6
      Related
      ENSMUSP00000143232.2, ENSMUST00000199243.5
      Conserved Domains (2) summary
      pfam04959
      Location:645843
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:153262
      DUF3546; Domain of unknown function (DUF3546)
    2. NM_001109910.1NP_001103380.1  serrate RNA effector molecule homolog isoform 3

      See identical proteins and their annotated locations for NP_001103380.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses different acceptor splice sites at the second and third to last exons compared to transcript variant 1, resulting in a shorter isoform (3) compared to isoform 1.
      Source sequence(s)
      AA986426, AK152710, BC066831, CJ175065
      Consensus CDS
      CCDS80439.1
      UniProtKB/Swiss-Prot
      Q99MR6
      Related
      ENSMUSP00000142564.2, ENSMUST00000197466.5
      Conserved Domains (2) summary
      pfam04959
      Location:645839
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:153262
      DUF3546; Domain of unknown function (DUF3546)
    3. NM_001359602.1NP_001346531.1  serrate RNA effector molecule homolog isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC150682, AC243288
      Conserved Domains (2) summary
      pfam04959
      Location:645846
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:153262
      DUF3546; Domain of unknown function (DUF3546)
    4. NM_031405.2NP_113582.1  serrate RNA effector molecule homolog isoform 1

      See identical proteins and their annotated locations for NP_113582.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA986426, BC066831, CB195376, CJ175065
      Consensus CDS
      CCDS39331.1
      UniProtKB/Swiss-Prot
      Q99MR6
      Related
      ENSMUSP00000043123.8, ENSMUST00000040873.12
      Conserved Domains (2) summary
      pfam04959
      Location:645850
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:153262
      DUF3546; Domain of unknown function (DUF3546)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      137293966..137306564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254930.2XP_030110790.1  serrate RNA effector molecule homolog isoform X4

      Conserved Domains (2) summary
      pfam04959
      Location:418612
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:135
      DUF3546; Domain of unknown function (DUF3546)
    2. XM_030254929.2XP_030110789.1  serrate RNA effector molecule homolog isoform X3

      Conserved Domains (2) summary
      pfam04959
      Location:418623
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:135
      DUF3546; Domain of unknown function (DUF3546)
    3. XM_006504631.3XP_006504694.1  serrate RNA effector molecule homolog isoform X2

      Conserved Domains (2) summary
      pfam04959
      Location:480685
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:3297
      DUF3546; Domain of unknown function (DUF3546)
    4. XM_030254928.2XP_030110788.1  serrate RNA effector molecule homolog isoform X3

      Conserved Domains (2) summary
      pfam04959
      Location:418623
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:135
      DUF3546; Domain of unknown function (DUF3546)
    5. XM_036165632.1XP_036021525.1  serrate RNA effector molecule homolog isoform X2

      Conserved Domains (2) summary
      pfam04959
      Location:480685
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:3297
      DUF3546; Domain of unknown function (DUF3546)
    6. XM_036165633.1XP_036021526.1  serrate RNA effector molecule homolog isoform X3

      Conserved Domains (2) summary
      pfam04959
      Location:418623
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:135
      DUF3546; Domain of unknown function (DUF3546)
    7. XM_030254927.2XP_030110787.1  serrate RNA effector molecule homolog isoform X2

      Conserved Domains (2) summary
      pfam04959
      Location:480685
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:3297
      DUF3546; Domain of unknown function (DUF3546)
    8. XM_006504630.2XP_006504693.1  serrate RNA effector molecule homolog isoform X1

      See identical proteins and their annotated locations for XP_006504693.1

      Conserved Domains (2) summary
      pfam04959
      Location:548753
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:56165
      DUF3546; Domain of unknown function (DUF3546)
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