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    RPS6KL1 ribosomal protein S6 kinase like 1 [ Homo sapiens (human) ]

    Gene ID: 83694, updated on 17-Jun-2024

    Summary

    Official Symbol
    RPS6KL1provided by HGNC
    Official Full Name
    ribosomal protein S6 kinase like 1provided by HGNC
    Primary source
    HGNC:HGNC:20222
    See related
    Ensembl:ENSG00000198208 AllianceGenome:HGNC:20222
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RSKL2
    Summary
    Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be located in ribosome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in brain (RPKM 4.6), testis (RPKM 3.0) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RPS6KL1 in Genome Data Viewer
    Location:
    14q24.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (74903951..74923260, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (69113051..69132361, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75370654..75389963, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene prospero homeobox 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75342793-75343292 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:75348551-75348777 Neighboring gene METTL5 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8732 Neighboring gene HNF4 motif-containing MPRA enhancer 140 Neighboring gene dihydrolipoamide S-succinyltransferase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75388716-75389487 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75389488-75390258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75401143-75401710 Neighboring gene uncharacterized LOC107984690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5938 Neighboring gene placental growth factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8733 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:75431938-75433137 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75446625-75447250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75447251-75447876 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75447877-75448500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8734 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:75469302-75469982 Neighboring gene eukaryotic translation initiation factor 2B subunit beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ35734, MGC11287

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ribosomal protein S6 kinase-like 1
    NP_001357181.1
    NP_001357182.1
    NP_001357184.1
    NP_001357185.1
    NP_001357186.1
    NP_001357187.1
    NP_113652.2
    XP_011535508.1
    XP_011535509.1
    XP_011535513.1
    XP_011535515.1
    XP_016877169.1
    XP_016877171.1
    XP_016877172.1
    XP_016877173.1
    XP_016877174.1
    XP_016877175.1
    XP_016877177.1
    XP_016877180.1
    XP_024305484.1
    XP_024305485.1
    XP_047287752.1
    XP_047287753.1
    XP_047287754.1
    XP_047287755.1
    XP_047287756.1
    XP_047287757.1
    XP_054232751.1
    XP_054232752.1
    XP_054232753.1
    XP_054232754.1
    XP_054232755.1
    XP_054232756.1
    XP_054232757.1
    XP_054232758.1
    XP_054232759.1
    XP_054232760.1
    XP_054232761.1
    XP_054232762.1
    XP_054232763.1
    XP_054232764.1
    XP_054232765.1
    XP_054232766.1
    XP_054232767.1
    XP_054232768.1
    XP_054232769.1
    XP_054232770.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034007.1 RefSeqGene

      Range
      4183..23492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001370252.1NP_001357181.1  ribosomal protein S6 kinase-like 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC006530
      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148508
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    2. NM_001370253.1NP_001357182.1  ribosomal protein S6 kinase-like 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC006530
      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:146499
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    3. NM_001370255.1NP_001357184.1  ribosomal protein S6 kinase-like 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC006530
      Conserved Domains (2) summary
      cd02677
      Location:48122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cl21453
      Location:148305
      PKc_like; Protein Kinases, catalytic domain
    4. NM_001370256.1NP_001357185.1  ribosomal protein S6 kinase-like 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC006530
      Conserved Domains (2) summary
      cd02677
      Location:48122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cl21453
      Location:148307
      PKc_like; Protein Kinases, catalytic domain
    5. NM_001370257.1NP_001357186.1  ribosomal protein S6 kinase-like 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC006530
      Conserved Domains (2) summary
      cd02677
      Location:48122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cl21453
      Location:131249
      PKc_like; Protein Kinases, catalytic domain
    6. NM_001370258.1NP_001357187.1  ribosomal protein S6 kinase-like 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC006530
      Conserved Domains (2) summary
      cd02677
      Location:48122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cl21453
      Location:131219
      PKc_like; Protein Kinases, catalytic domain
    7. NM_031464.5NP_113652.2  ribosomal protein S6 kinase-like 1 isoform 2

      See identical proteins and their annotated locations for NP_113652.2

      Status: VALIDATED

      Source sequence(s)
      AC006530, AK299846
      Consensus CDS
      CCDS9834.2
      UniProtKB/Swiss-Prot
      A6NGM9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9, Q9Y6S9
      UniProtKB/TrEMBL
      B4DSP6
      Related
      ENSP00000450567.1, ENST00000557413.6
      Conserved Domains (2) summary
      cd02677
      Location:48122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148539
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    RNA

    1. NR_163404.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC006530
    2. NR_163405.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC006530
    3. NR_163406.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC006530

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      74903951..74923260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431797.1XP_047287753.1  ribosomal protein S6 kinase-like 1 isoform X6

      UniProtKB/TrEMBL
      B4DSP6
    2. XM_017021682.2XP_016877171.1  ribosomal protein S6 kinase-like 1 isoform X2

      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148539
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    3. XM_047431796.1XP_047287752.1  ribosomal protein S6 kinase-like 1 isoform X2

      UniProtKB/TrEMBL
      B4DSP6
    4. XM_024449717.2XP_024305485.1  ribosomal protein S6 kinase-like 1 isoform X2

      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148539
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    5. XM_011537206.4XP_011535508.1  ribosomal protein S6 kinase-like 1 isoform X1

      See identical proteins and their annotated locations for XP_011535508.1

      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148555
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    6. XM_011537213.4XP_011535515.1  ribosomal protein S6 kinase-like 1 isoform X7

      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:131492
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    7. XM_017021691.3XP_016877180.1  ribosomal protein S6 kinase-like 1 isoform X14

    8. XM_047431800.1XP_047287756.1  ribosomal protein S6 kinase-like 1 isoform X12

    9. XM_011537211.4XP_011535513.1  ribosomal protein S6 kinase-like 1 isoform X6

      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:131508
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    10. XM_047431801.1XP_047287757.1  ribosomal protein S6 kinase-like 1 isoform X13

    11. XM_024449716.2XP_024305484.1  ribosomal protein S6 kinase-like 1 isoform X2

      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148539
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    12. XM_017021688.3XP_016877177.1  ribosomal protein S6 kinase-like 1 isoform X11

      Conserved Domains (3) summary
      smart00220
      Location:177353
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd02677
      Location:48122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cl21453
      Location:148353
      PKc_like; Protein Kinases, catalytic domain
    13. XM_017021683.3XP_016877172.1  ribosomal protein S6 kinase-like 1 isoform X3

      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cl21453
      Location:148525
      PKc_like; Protein Kinases, catalytic domain
    14. XM_017021684.3XP_016877173.1  ribosomal protein S6 kinase-like 1 isoform X4

      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148523
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    15. XM_017021680.3XP_016877169.1  ribosomal protein S6 kinase-like 1 isoform X1

      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148555
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    16. XM_011537207.3XP_011535509.1  ribosomal protein S6 kinase-like 1 isoform X1

      See identical proteins and their annotated locations for XP_011535509.1

      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148555
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    17. XM_047431799.1XP_047287755.1  ribosomal protein S6 kinase-like 1 isoform X9

      UniProtKB/TrEMBL
      B4DSP6
      Related
      ENSP00000450660.1, ENST00000555009.5
    18. XM_047431798.1XP_047287754.1  ribosomal protein S6 kinase-like 1 isoform X8

      UniProtKB/TrEMBL
      B4DSP6
    19. XM_017021685.3XP_016877174.1  ribosomal protein S6 kinase-like 1 isoform X5

      UniProtKB/TrEMBL
      B4DSP6
      Conserved Domains (2) summary
      cd02677
      Location:48122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:148555
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
    20. XM_017021686.3XP_016877175.1  ribosomal protein S6 kinase-like 1 isoform X10

      Conserved Domains (2) summary
      cd02677
      Location:48122
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cl21453
      Location:148439
      PKc_like; Protein Kinases, catalytic domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      69113051..69132361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376787.1XP_054232762.1  ribosomal protein S6 kinase-like 1 isoform X6

      UniProtKB/TrEMBL
      B4DSP6
    2. XM_054376781.1XP_054232756.1  ribosomal protein S6 kinase-like 1 isoform X2

      UniProtKB/TrEMBL
      B4DSP6
    3. XM_054376782.1XP_054232757.1  ribosomal protein S6 kinase-like 1 isoform X2

      UniProtKB/TrEMBL
      B4DSP6
    4. XM_054376780.1XP_054232755.1  ribosomal protein S6 kinase-like 1 isoform X2

      UniProtKB/TrEMBL
      B4DSP6
    5. XM_054376778.1XP_054232753.1  ribosomal protein S6 kinase-like 1 isoform X1

      UniProtKB/TrEMBL
      B4DSP6
    6. XM_054376788.1XP_054232763.1  ribosomal protein S6 kinase-like 1 isoform X7

      UniProtKB/TrEMBL
      B4DSP6
    7. XM_054376795.1XP_054232770.1  ribosomal protein S6 kinase-like 1 isoform X14

    8. XM_054376793.1XP_054232768.1  ribosomal protein S6 kinase-like 1 isoform X12

    9. XM_054376786.1XP_054232761.1  ribosomal protein S6 kinase-like 1 isoform X6

      UniProtKB/TrEMBL
      B4DSP6
    10. XM_054376794.1XP_054232769.1  ribosomal protein S6 kinase-like 1 isoform X13

    11. XM_054376779.1XP_054232754.1  ribosomal protein S6 kinase-like 1 isoform X2

      UniProtKB/TrEMBL
      B4DSP6
    12. XM_054376792.1XP_054232767.1  ribosomal protein S6 kinase-like 1 isoform X11

    13. XM_054376783.1XP_054232758.1  ribosomal protein S6 kinase-like 1 isoform X3

      UniProtKB/TrEMBL
      B4DSP6
    14. XM_054376784.1XP_054232759.1  ribosomal protein S6 kinase-like 1 isoform X4

      UniProtKB/TrEMBL
      B4DSP6
    15. XM_054376776.1XP_054232751.1  ribosomal protein S6 kinase-like 1 isoform X1

      UniProtKB/TrEMBL
      B4DSP6
    16. XM_054376777.1XP_054232752.1  ribosomal protein S6 kinase-like 1 isoform X1

      UniProtKB/TrEMBL
      B4DSP6
    17. XM_054376790.1XP_054232765.1  ribosomal protein S6 kinase-like 1 isoform X9

      UniProtKB/TrEMBL
      B4DSP6
    18. XM_054376789.1XP_054232764.1  ribosomal protein S6 kinase-like 1 isoform X8

      UniProtKB/TrEMBL
      B4DSP6
    19. XM_054376785.1XP_054232760.1  ribosomal protein S6 kinase-like 1 isoform X5

      UniProtKB/TrEMBL
      B4DSP6
    20. XM_054376791.1XP_054232766.1  ribosomal protein S6 kinase-like 1 isoform X10