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    TLN2 talin 2 [ Homo sapiens (human) ]

    Gene ID: 83660, updated on 7-Oct-2018

    Summary

    Official Symbol
    TLN2provided by HGNC
    Official Full Name
    talin 2provided by HGNC
    Primary source
    HGNC:HGNC:15447
    See related
    Ensembl:ENSG00000171914 MIM:607349; Vega:OTTHUMG00000133679
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ILWEQ
    Summary
    This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in kidney (RPKM 12.9), brain (RPKM 11.8) and 19 other tissues See more
    Orthologs

    Genomic context

    See TLN2 in Genome Data Viewer
    Location:
    15q22.2
    Exon count:
    68
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (62390523..62844631)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (62682769..63136830)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene microRNA 6085 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 26 Neighboring gene uncharacterized LOC105370855 Neighboring gene uncharacterized protein MGC15885 Neighboring gene uncharacterized LOC105370854 Neighboring gene microRNA 190a Neighboring gene nuclease-sensitive element-binding protein 1 pseudogene Neighboring gene TPM1 antisense RNA Neighboring gene tropomyosin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A genome-wide association study of sleep habits and insomnia.
    NHGRI GWA Catalog
    Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    matrix gag HIV-1 MA co-localizes with beta2 integrin, alphaM and alphaX integrins in the intracellular thick electron-dense membrane compartments, which contain talin, vinculin and paxillin that connect the integrin complexes to the actin cytoskeleton PubMed
    retropepsin gag-pol A number of focal adhesion plaque proteins are specifically cleaved by HIV-1 protease, including fimbrin, focal adhesion plaque kinase (FAK), talin, and, to a lesser extent, filamin, spectrin and fibronectin PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Platelet activation, organism-specific biosystem (from KEGG)
      Platelet activation, organism-specific biosystemPlatelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by ad...
    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0320, DKFZp451B1011, DKFZp686I0976, DKFZp686K0979

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    structural molecule activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell-cell junction assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoskeletal anchoring at plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    actin cytoskeleton NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion HDA PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    ruffle IEA
    Inferred from Electronic Annotation
    more info
     
    synapse NAS
    Non-traceable Author Statement
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033932.1 RefSeqGene

      Range
      5001..202321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_015059.2NP_055874.2  talin-2

      See identical proteins and their annotated locations for NP_055874.2

      Status: REVIEWED

      Source sequence(s)
      AC068233, AC100839, AC103740, AF402000
      Consensus CDS
      CCDS32261.1
      UniProtKB/Swiss-Prot
      Q9Y4G6
      Related
      ENSP00000453508.1, OTTHUMP00000165050, ENST00000561311.5, OTTHUMT00000257878
      Conserved Domains (10) summary
      cd12150
      Location:16561827
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:90316
      B41; Band 4.1 homologues
      smart00307
      Location:23372532
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:206316
      FERM_M; FERM central domain
      pfam08913
      Location:18501974
      VBS; Vinculin Binding Site
      pfam09141
      Location:494655
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92188
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:706832
      I_LWEQ; I/LWEQ domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

      Range
      62390523..62844631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450087.1XP_024305855.1  talin-2 isoform X1

      Conserved Domains (8) summary
      cd12150
      Location:16561827
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:90316
      B41; Band 4.1 homologues
      smart00307
      Location:23372547
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:18501974
      VBS; Vinculin Binding Site
      pfam09141
      Location:494655
      Talin_middle; Talin, middle domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:706842
      I_LWEQ; I/LWEQ domain
    2. XM_005254714.3XP_005254771.1  talin-2 isoform X1

      See identical proteins and their annotated locations for XP_005254771.1

      Conserved Domains (8) summary
      cd12150
      Location:16561827
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:90316
      B41; Band 4.1 homologues
      smart00307
      Location:23372547
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:18501974
      VBS; Vinculin Binding Site
      pfam09141
      Location:494655
      Talin_middle; Talin, middle domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:706842
      I_LWEQ; I/LWEQ domain
    3. XM_005254708.4XP_005254765.1  talin-2 isoform X1

      See identical proteins and their annotated locations for XP_005254765.1

      Conserved Domains (8) summary
      cd12150
      Location:16561827
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:90316
      B41; Band 4.1 homologues
      smart00307
      Location:23372547
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:18501974
      VBS; Vinculin Binding Site
      pfam09141
      Location:494655
      Talin_middle; Talin, middle domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:706842
      I_LWEQ; I/LWEQ domain
    4. XM_005254710.5XP_005254767.1  talin-2 isoform X1

      See identical proteins and their annotated locations for XP_005254767.1

      Conserved Domains (8) summary
      cd12150
      Location:16561827
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:90316
      B41; Band 4.1 homologues
      smart00307
      Location:23372547
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:18501974
      VBS; Vinculin Binding Site
      pfam09141
      Location:494655
      Talin_middle; Talin, middle domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:706842
      I_LWEQ; I/LWEQ domain
    5. XM_005254711.5XP_005254768.1  talin-2 isoform X1

      See identical proteins and their annotated locations for XP_005254768.1

      Conserved Domains (8) summary
      cd12150
      Location:16561827
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:90316
      B41; Band 4.1 homologues
      smart00307
      Location:23372547
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:18501974
      VBS; Vinculin Binding Site
      pfam09141
      Location:494655
      Talin_middle; Talin, middle domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:706842
      I_LWEQ; I/LWEQ domain
    6. XM_005254712.4XP_005254769.1  talin-2 isoform X1

      See identical proteins and their annotated locations for XP_005254769.1

      Conserved Domains (8) summary
      cd12150
      Location:16561827
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:90316
      B41; Band 4.1 homologues
      smart00307
      Location:23372547
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:18501974
      VBS; Vinculin Binding Site
      pfam09141
      Location:494655
      Talin_middle; Talin, middle domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:706842
      I_LWEQ; I/LWEQ domain
    7. XM_017022665.2XP_016878154.1  talin-2 isoform X1

      Conserved Domains (8) summary
      cd12150
      Location:16561827
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:90316
      B41; Band 4.1 homologues
      smart00307
      Location:23372547
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:18501974
      VBS; Vinculin Binding Site
      pfam09141
      Location:494655
      Talin_middle; Talin, middle domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:706842
      I_LWEQ; I/LWEQ domain
    8. XM_005254713.5XP_005254770.1  talin-2 isoform X1

      See identical proteins and their annotated locations for XP_005254770.1

      Conserved Domains (8) summary
      cd12150
      Location:16561827
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:90316
      B41; Band 4.1 homologues
      smart00307
      Location:23372547
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:18501974
      VBS; Vinculin Binding Site
      pfam09141
      Location:494655
      Talin_middle; Talin, middle domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:706842
      I_LWEQ; I/LWEQ domain
    9. XM_006720717.4XP_006720780.1  talin-2 isoform X1

      See identical proteins and their annotated locations for XP_006720780.1

      Conserved Domains (8) summary
      cd12150
      Location:16561827
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:90316
      B41; Band 4.1 homologues
      smart00307
      Location:23372547
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:18501974
      VBS; Vinculin Binding Site
      pfam09141
      Location:494655
      Talin_middle; Talin, middle domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:706842
      I_LWEQ; I/LWEQ domain
    10. XM_005254715.3XP_005254772.1  talin-2 isoform X1

      See identical proteins and their annotated locations for XP_005254772.1

      Conserved Domains (8) summary
      cd12150
      Location:16561827
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:90316
      B41; Band 4.1 homologues
      smart00307
      Location:23372547
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:18501974
      VBS; Vinculin Binding Site
      pfam09141
      Location:494655
      Talin_middle; Talin, middle domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:706842
      I_LWEQ; I/LWEQ domain
    11. XM_017022669.1XP_016878158.1  talin-2 isoform X3

      Conserved Domains (10) summary
      cd12150
      Location:16111782
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:90316
      B41; Band 4.1 homologues
      smart00307
      Location:22922502
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:206316
      FERM_M; FERM central domain
      pfam08913
      Location:18051929
      VBS; Vinculin Binding Site
      pfam09141
      Location:494655
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92188
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:706832
      I_LWEQ; I/LWEQ domain
    12. XM_017022668.2XP_016878157.1  talin-2 isoform X2

      UniProtKB/Swiss-Prot
      Q9Y4G6
      Conserved Domains (10) summary
      cd12150
      Location:16561827
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:90316
      B41; Band 4.1 homologues
      smart00307
      Location:23372532
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:206316
      FERM_M; FERM central domain
      pfam08913
      Location:18501974
      VBS; Vinculin Binding Site
      pfam09141
      Location:494655
      Talin_middle; Talin, middle domain
      pfam09379
      Location:92188
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:706832
      I_LWEQ; I/LWEQ domain
    13. XM_017022666.1XP_016878155.1  talin-2 isoform X1

      Conserved Domains (8) summary
      cd12150
      Location:16561827
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:90316
      B41; Band 4.1 homologues
      smart00307
      Location:23372547
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:18501974
      VBS; Vinculin Binding Site
      pfam09141
      Location:494655
      Talin_middle; Talin, middle domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:706842
      I_LWEQ; I/LWEQ domain
    14. XM_017022667.1XP_016878156.1  talin-2 isoform X1

      Conserved Domains (8) summary
      cd12150
      Location:16561827
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:90316
      B41; Band 4.1 homologues
      smart00307
      Location:23372547
      ILWEQ; I/LWEQ domain
      cd10569
      Location:312403
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam08913
      Location:18501974
      VBS; Vinculin Binding Site
      pfam09141
      Location:494655
      Talin_middle; Talin, middle domain
      pfam16511
      Location:485
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:706842
      I_LWEQ; I/LWEQ domain

    RNA

    1. XR_001751405.2 RNA Sequence

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