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    TEX101 testis expressed 101 [ Homo sapiens (human) ]

    Gene ID: 83639, updated on 17-Jun-2024

    Summary

    Official Symbol
    TEX101provided by HGNC
    Official Full Name
    testis expressed 101provided by HGNC
    Primary source
    HGNC:HGNC:30722
    See related
    Ensembl:ENSG00000131126 MIM:612665; AllianceGenome:HGNC:30722
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SGRG; CT131; GTPR867; NYD-SP8; PRO1884; SPATA44; TES101RP
    Summary
    Predicted to be involved in binding activity of sperm to zona pellucida; flagellated sperm motility; and regulation of flagellated sperm motility. Predicted to be located in acrosomal vesicle; extracellular region; and plasma membrane. Predicted to be active in plasma membrane raft. Predicted to be anchored component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis (RPKM 41.7) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TEX101 in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43388611..43418597)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46209044..46238972)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43892763..43922749)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:43868357-43868858 Neighboring gene CD177 molecule Neighboring gene CD177 molecule pseudogene 1 Neighboring gene RNA, 28S ribosomal pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr19:43917243-43917429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10717 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:43967981-43968512 Neighboring gene LY6/PLAUR domain containing 3 Neighboring gene pleckstrin homology like domain family B member 3 Neighboring gene Sharpr-MPRA regulatory region 2471 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44008034-44008556

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    The Contribution of Common Genetic Variation to Nicotine and Cotinine Glucuronidation in Multiple Ethnic/Racial Populations.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC4766

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in binding of sperm to zona pellucida ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fertilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in acrosomal vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in plasma membrane raft IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    testis-expressed protein 101
    Names
    TES101-reactive protein
    cancer/testis antigen 131
    cell surface receptor NYD-SP8
    scleroderma-associated autoantigen
    spermatogenesis associated 44
    spermatogenesis-related gene protein
    testis expressed sequence 101
    testis-expressed sequence 101 protein
    testis-specific protein TES101RP

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130011.3NP_001123483.1  testis-expressed protein 101 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001123483.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the 5' end and uses a downstream translation start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when compared to isoform 1.
      Source sequence(s)
      AC018758, AY359077
      Consensus CDS
      CCDS59393.1
      UniProtKB/Swiss-Prot
      Q7L5R2, Q9BPY7, Q9BY14
      Related
      ENSP00000472769.1, ENST00000598265.2
      Conserved Domains (1) summary
      cl10471
      Location:140209
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    2. NM_031451.5NP_113639.4  testis-expressed protein 101 isoform 1

      See identical proteins and their annotated locations for NP_113639.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AA417291, AF241268, BC001861
      Consensus CDS
      CCDS12619.1
      Related
      ENSP00000472308.1, ENST00000602198.5
      Conserved Domains (1) summary
      cl10471
      Location:158227
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      43388611..43418597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005259303.4XP_005259360.3  testis-expressed protein 101 isoform X1

      Related
      ENST00000601707.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      46209044..46238972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322297.1XP_054178272.1  testis-expressed protein 101 isoform X1