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    H2BC17 H2B clustered histone 17 [ Homo sapiens (human) ]

    Gene ID: 8348, updated on 17-Jun-2024

    Summary

    Official Symbol
    H2BC17provided by HGNC
    Official Full Name
    H2B clustered histone 17provided by HGNC
    Primary source
    HGNC:HGNC:4758
    See related
    Ensembl:ENSG00000274641 MIM:602808; AllianceGenome:HGNC:4758
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H2B.2; H2B/n; H2BFN; HIST1H2BO; dJ193B12.2
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
    Orthologs
    NEW
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    Genomic context

    See H2BC17 in Genome Data Viewer
    Location:
    6p22.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (27893425..27893891)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (27763076..27763542)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (27861203..27861669)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:27857551-27858195 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:27858196-27858840 Neighboring gene H3 clustered histone 12 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:27860089-27860632 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:27860633-27861176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24337 Neighboring gene H2A clustered histone 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24339 Neighboring gene CRISPRi-validated cis-regulatory element chr6.1313 Neighboring gene RNA, U7 small nuclear 26 pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr6.1314 Neighboring gene CRISPRi-validated cis-regulatory element chr6.1315 Neighboring gene tRNA-iMet (anticodon CAT) 1-7

    Genomic regions, transcripts, and products

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC119806

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in nucleosome assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of nucleosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone H2B type 1-O
    Names
    H2B histone family, member N
    histone 1, H2bo
    histone H2B.2
    histone H2B.n
    histone cluster 1 H2B family member o
    histone cluster 1, H2bo

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003527.4NP_003518.2  histone H2B type 1-O

      See identical proteins and their annotated locations for NP_003518.2

      Status: REVIEWED

      Source sequence(s)
      Z98744
      Consensus CDS
      CCDS4640.1
      UniProtKB/Swiss-Prot
      P23527, Q3KPI7, Q8TCV6
      UniProtKB/TrEMBL
      Q0D2M2
      Related
      ENSP00000477527.2, ENST00000616182.2
      Conserved Domains (1) summary
      smart00427
      Location:28124
      H2B; Histone H2B

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      27893425..27893891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      27763076..27763542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)