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    SLC25A31 solute carrier family 25 member 31 [ Homo sapiens (human) ]

    Gene ID: 83447, updated on 5-May-2024

    Summary

    Official Symbol
    SLC25A31provided by HGNC
    Official Full Name
    solute carrier family 25 member 31provided by HGNC
    Primary source
    HGNC:HGNC:25319
    See related
    Ensembl:ENSG00000151475 MIM:610796; AllianceGenome:HGNC:25319
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AAC4; ANT4; ANT 4; SFEC35kDa
    Summary
    The protein encoded by this gene is a member of the ADP/ATP carrier family of proteins that exchange cytosolic ADP for matrix ATP in the mitochondria. Cells over-expressing this gene have been shown to display an anti-apoptotic phenotype. This protein is also thought to play a role in spermatogenesis, where it is believed to associate with a part of the flagellar cytoskeleton and with glycolytic enzymes. Male mice with mutations in the mouse ortholog of this gene are sterile and spermatocytes display an early meiotic arrest phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
    Expression
    Restricted expression toward testis (RPKM 32.1) See more
    Orthologs
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    Genomic context

    Location:
    4q28.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (127730400..127774292)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (131033425..131077300)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (128651555..128695447)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377412 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:128525826-128526649 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:128553760-128554299 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:128576502-128577102 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:128577103-128577701 Neighboring gene inturned planar cell polarity protein Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:128607842-128609041 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:128629462-128630661 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:128651275-128651432 Neighboring gene uncharacterized LOC105377414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15671 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15673 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15674 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:128703547-128704539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21886 Neighboring gene heat shock protein family A (Hsp70) member 4 like Neighboring gene SOSS complex subunit C-like Neighboring gene ribosomal protein L21 pseudogene 53

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp434N1235

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP:ADP antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male meiosis I ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrial ADP transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrial ATP transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of mitochondrial membrane permeability ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of mitochondrial permeability transition pore complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus HDA PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ADP/ATP translocase 4
    Names
    ADP,ATP carrier protein 4
    adenine nucleotide translocase 4
    adenine nucleotide translocator 4
    solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31
    sperm flagellar energy carrier protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318467.2NP_001305396.1  ADP/ATP translocase 4 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC093591, AL136857, BC022032, BG192958, BM563946, BQ438347, BU853653
      UniProtKB/Swiss-Prot
      Q9H0C2
      Conserved Domains (1) summary
      cl28162
      Location:19252
      Mito_carr; Mitochondrial carrier protein
    2. NM_031291.4NP_112581.1  ADP/ATP translocase 4 isoform 1

      See identical proteins and their annotated locations for NP_112581.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC022032, BG192958, BQ438347
      Consensus CDS
      CCDS3733.1
      UniProtKB/Swiss-Prot
      Q9H0C2
      Related
      ENSP00000281154.4, ENST00000281154.6
      Conserved Domains (1) summary
      PTZ00169
      Location:19309
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      127730400..127774292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532298.3XP_011530600.1  ADP/ATP translocase 4 isoform X1

      Conserved Domains (2) summary
      PTZ00169
      Location:19218
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:16112
      Mito_carr; Mitochondrial carrier protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      131033425..131077300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350951.1XP_054206926.1  ADP/ATP translocase 4 isoform X1