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    Ndel1 nudE neurodevelopment protein 1 like 1 [ Mus musculus (house mouse) ]

    Gene ID: 83431, updated on 7-Aug-2018

    Summary

    Official Symbol
    Ndel1provided by MGI
    Official Full Name
    nudE neurodevelopment protein 1 like 1provided by MGI
    Primary source
    MGI:MGI:1932915
    See related
    Ensembl:ENSMUSG00000018736 Vega:OTTMUSG00000005956
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NUDEL; MITAP1; mNudel; mNudE-L; 2600006O07Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 44.1), ovary adult (RPKM 37.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ndel1 in Genome Data Viewer
    Location:
    11; 11 B3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (68821434..68853131, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (68634936..68666633, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 42 Neighboring gene myosin, heavy polypeptide 10, non-muscle Neighboring gene ring finger protein 222 Neighboring gene ribosomal protein L26

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    alpha-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oligopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    activation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    central nervous system neuron axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    centrosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    centrosome localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebral cortex radially oriented cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of chromosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    establishment of mitotic spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inner cell mass cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosome localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic centrosome separation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic centrosome separation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mitotic centrosome separation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    neurofilament cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    nuclear envelope disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of axon regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ruffle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    retrograde axonal transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vesicle transport along microtubule IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    axon hillock IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell body ISO
    Inferred from Sequence Orthology
    more info
     
    cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    central region of growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    kinesin complex ISO
    Inferred from Sequence Orthology
    more info
     
    kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule organizing center IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neurofilament cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear distribution protein nudE-like 1
    Names
    nuclear disribution gene E like
    nuclear distribution gene E-like homolog 1
    protein Nudel

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363304.1NP_001350233.1  nuclear distribution protein nudE-like 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK146029, AL603662
      Conserved Domains (2) summary
      pfam04880
      Location:135309
      NUDE_C; NUDE protein, C-terminal conserved region
      cl25732
      Location:24195
      SMC_N; RecF/RecN/SMC N terminal domain
    2. NM_001363305.1NP_001350234.1  nuclear distribution protein nudE-like 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL603662
      Conserved Domains (1) summary
      pfam04880
      Location:6142
      NUDE_C; NUDE protein, C-terminal conserved region
    3. NM_023668.3NP_076157.2  nuclear distribution protein nudE-like 1 isoform 1

      See identical proteins and their annotated locations for NP_076157.2

      Status: VALIDATED

      Source sequence(s)
      BC046796, BY124052, CJ092278
      Consensus CDS
      CCDS24870.1
      UniProtKB/Swiss-Prot
      Q9ERR1
      Related
      ENSMUSP00000018880.7, OTTMUSP00000006155, ENSMUST00000018880.13
      Conserved Domains (2) summary
      pfam04880
      Location:135308
      NUDE_C; NUDE protein, C-terminal conserved region
      pfam15035
      Location:45194
      Rootletin; Ciliary rootlet component, centrosome cohesion

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      68821434..68853131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534540.1XP_006534603.1  nuclear distribution protein nudE-like 1 isoform X1

      Conserved Domains (2) summary
      pfam04880
      Location:135309
      NUDE_C; NUDE protein, C-terminal conserved region
      cl25732
      Location:24195
      SMC_N; RecF/RecN/SMC N terminal domain
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