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    Ndel1 nudE neurodevelopment protein 1 like 1 [ Mus musculus (house mouse) ]

    Gene ID: 83431, updated on 16-Oct-2021

    Summary

    Official Symbol
    Ndel1provided by MGI
    Official Full Name
    nudE neurodevelopment protein 1 like 1provided by MGI
    Primary source
    MGI:MGI:1932915
    See related
    Ensembl:ENSMUSG00000018736
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NUDEL; MITAP1; mNudel; mNudE-L; 2600006O07Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 44.1), ovary adult (RPKM 37.2) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ndel1 in Genome Data Viewer
    Location:
    11; 11 B3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (68712260..68743961, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (68821434..68853146, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (68634936..68666633, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm213 Neighboring gene myosin, heavy polypeptide 10, non-muscle Neighboring gene predicted gene, 53684 Neighboring gene predicted gene, 53685 Neighboring gene ring finger protein 222 Neighboring gene ribosomal protein L26

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables beta-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oligopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within activation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT involved_in canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within central nervous system neuron axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in centrosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within centrosome localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cerebral cortex radially oriented cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of chromosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in establishment of mitotic spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within inner cell mass cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lysosome localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within microtubule cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitotic centrosome separation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within mitotic centrosome separation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within mitotic centrosome separation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within neurofilament cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron projection extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within nuclear membrane disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of axon regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ruffle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within retrograde axonal transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within vesicle transport along microtubule IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon hillock IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in central region of growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of kinesin complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    part_of microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule organizing center IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    located_in neurofilament cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear distribution protein nudE-like 1
    Names
    nuclear disribution gene E like
    nuclear distribution gene E-like homolog 1
    protein Nudel

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363304.1NP_001350233.1  nuclear distribution protein nudE-like 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK146029, AL603662
      Conserved Domains (2) summary
      TIGR02168
      Location:24195
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam04880
      Location:135309
      NUDE_C; NUDE protein, C-terminal conserved region
    2. NM_001363305.1NP_001350234.1  nuclear distribution protein nudE-like 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL603662
      Conserved Domains (1) summary
      pfam04880
      Location:6142
      NUDE_C; NUDE protein, C-terminal conserved region
    3. NM_023668.3NP_076157.2  nuclear distribution protein nudE-like 1 isoform 1

      See identical proteins and their annotated locations for NP_076157.2

      Status: VALIDATED

      Source sequence(s)
      BC046796, BY124052, CJ092278
      Consensus CDS
      CCDS24870.1
      UniProtKB/Swiss-Prot
      Q9ERR1
      Related
      ENSMUSP00000018880.8, ENSMUST00000018880.14
      Conserved Domains (2) summary
      TIGR02168
      Location:24195
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam04880
      Location:135309
      NUDE_C; NUDE protein, C-terminal conserved region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      68712260..68743961 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246442.2XP_030102302.1  nuclear distribution protein nudE-like 1 isoform X1

      Conserved Domains (2) summary
      TIGR02168
      Location:24195
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam04880
      Location:135309
      NUDE_C; NUDE protein, C-terminal conserved region
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