Format

Send to:

Choose Destination
    • Showing Current items.

    Akap12 A kinase (PRKA) anchor protein (gravin) 12 [ Mus musculus (house mouse) ]

    Gene ID: 83397, updated on 5-Sep-2021

    Summary

    Official Symbol
    Akap12provided by MGI
    Official Full Name
    A kinase (PRKA) anchor protein (gravin) 12provided by MGI
    Primary source
    MGI:MGI:1932576
    See related
    Ensembl:ENSMUSG00000038587
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sr; SSe; Tsga; Srcs5; SSeCKS; Tsga12; AI317366
    Expression
    Biased expression in testis adult (RPKM 189.4), bladder adult (RPKM 35.0) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Akap12 in Genome Data Viewer
    Location:
    10; 10 A1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (4216329..4309471)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (4266329..4359471)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (5987070..6080212, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25369 Neighboring gene predicted gene, 30570 Neighboring gene predicted gene, 40592 Neighboring gene zinc finger and BTB domain containing 2 Neighboring gene required for meiotic nuclear division 1 homolog Neighboring gene acidic residue methyltransferase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables adenylate cyclase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase A binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor complex adaptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of vascular permeability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hepatic stellate cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric-oxide synthase biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of oligodendrocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase A signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein kinase A signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein kinase C signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    A-kinase anchor protein 12
    Names
    AKAP-12
    gercelin
    germ cell lineage protein gercelin
    src-suppressed C kinase substrate
    testis specific gene A12
    v-src suppressed transcript 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031185.3NP_112462.1  A-kinase anchor protein 12

      See identical proteins and their annotated locations for NP_112462.1

      Status: VALIDATED

      Source sequence(s)
      AB051563, AI836130, CD540754
      Consensus CDS
      CCDS56673.1
      UniProtKB/Swiss-Prot
      Q9WTQ5
      UniProtKB/TrEMBL
      B2RRE0
      Related
      ENSMUSP00000035829.6, ENSMUST00000045730.7
      Conserved Domains (1) summary
      pfam03832
      Location:592619
      WSK; WSK motif

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      4216329..4309471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center